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PhosphoSitePlus
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Protein Page:
GSC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GSC Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 14q32.1
Biological Process: middle ear morphogenesis; neural crest cell fate specification
Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
Reference #:  P56915 (UniProtKB)
Alt. Names/Synonyms: goosecoid homeobox; GSC; Homeobox protein goosecoid
Gene Symbols: GSC
Molecular weight: 28,150 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below

GSC

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K183 ENLFQETKYPDVGTR
1 0 K196 TREQLARKVHLREEK
1 0 K203 KVHLREEKVEVWFKN
1 0 K209 EKVEVWFKNRRAKWR
1 0 K214 WFKNRRAKWRRQKRS
1 0 K239 WNKTSSSKAsPEKRE
0 1 S241‑p KTSSSKAsPEKREEE
0 1 K250‑ac EKREEEGksDLDSDS
0 1 S251‑p KREEEGksDLDSDS_
  mouse

 
K183‑sm ENLFQETkYPDVGTR
K196‑sm TREQLARkVHLREEk
K203‑sm kVHLREEkVEVWFkN
K209‑sm EkVEVWFkNRRAkWR
K214‑sm WFkNRRAkWRRQKRS
K238‑sm KWNKTSSkASPEKRE
S240 NKTSSkASPEKREEE
K249 EKREEEGKSDLDSDS
S250 KREEEGKSDLDSDS_
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