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Protein Page:
Tau (human)

Overview
Tau a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.1
Cellular Component: axon; cytosol; dendrite; growth cone; microtubule associated complex; plasma membrane; tubulin complex
Molecular Function: apolipoprotein binding; enzyme binding; microtubule binding; protein binding; SH3 domain binding; structural constituent of cytoskeleton
Biological Process: microtubule cytoskeleton organization and biogenesis; positive regulation of axon extension; positive regulation of microtubule polymerization; regulation of autophagy
Disease: Frontotemporal Dementia; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related; Parkinson Disease, Late-onset; Parkinson-dementia Syndrome; Pick Disease Of Brain; Supranuclear Palsy, Progressive, 1
Reference #:  P10636 (UniProtKB)
Alt. Names/Synonyms: DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; MAPTL; MGC138549; Microtubule-associated protein tau; MSTD; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; PPND; TAU
Gene Symbols: MAPT
Molecular weight: 78,928 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Tau

Protein Structure Not Found.
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