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Protein Page:
SNCA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SNCA a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May integrate presynaptic signaling and membrane trafficking. Implicated in the pathogenesis of Parkinson's disease. A major component of amyloid plaques in the brains of patients with Alzheimer's disease. Two alternatively spliced isoforms transcripts have been identified. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: actin cytoskeleton; axon; cell cortex; cytoplasm; cytosol; extracellular region; extracellular space; fibril; growth cone; inclusion body; lysosome; membrane; mitochondrial respiratory chain complex I; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; platelet alpha granule membrane
Molecular Function: alpha-tubulin binding; calcium ion binding; caspase inhibitor activity; copper ion binding; dynein binding; fatty acid binding; ferrous iron binding; histone binding; identical protein binding; kinesin binding; magnesium ion binding; oxidoreductase activity; phospholipid binding; phosphoprotein binding; protein binding; tau protein binding; zinc ion binding
Biological Process: calcium ion homeostasis; caspase activation; cellular protein metabolic process; dopamine biosynthetic process; dopamine uptake; fibril organization and biogenesis; microglial cell activation; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of dopamine uptake; negative regulation of exocytosis; negative regulation of histone acetylation; negative regulation of microtubule polymerization; negative regulation of monooxygenase activity; negative regulation of norepinephrine uptake; negative regulation of serotonin uptake; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transporter activity; positive regulation of apoptosis; positive regulation of endocytosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of receptor recycling; positive regulation of release of sequestered calcium ion into cytosol; protein destabilization; receptor internalization; regulation of dopamine secretion; response to iron(II) ion; response to lipopolysaccharide; response to magnesium ion; synaptic vesicle endocytosis
Disease: Dementia, Lewy Body; Parkinson Disease 1, Autosomal Dominant; Parkinson Disease 4, Autosomal Dominant
Reference #:  P37840 (UniProtKB)
Alt. Names/Synonyms: Alpha-synuclein; alpha-synuclein, isoform NACP140; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; SNCA; synuclein, alpha (non A4 component of amyloid precursor); SYUA
Gene Symbols: SNCA
Molecular weight: 14,460 Da
Basal Isoelectric point: 4.67  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SNCA

Protein Structure Not Found.
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Download ChimeraX Script


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Sites Implicated In
apoptosis, altered: Y39‑p
apoptosis, induced: S87‑p, S129‑p
apoptosis, inhibited: S129‑p
endocytosis, altered: S129‑p
activity, induced: S129‑p
activity, inhibited: Y125‑p
intracellular localization: S129‑p
molecular association, regulation: Y39‑p, S129‑p
phosphorylation: Y39‑p
protein conformation: S129‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K6 __MDVFMKGLSkAkE
0 1 K6 __MDVFMKGLSkAkE
1 0 K6‑sm __MDVFMkGLSkAkE
1 0 K10‑sm VFMkGLSkAkEGVVA
0 1 K12 MkGLSkAKEGVVAAA
0 1 K12‑ub MkGLSkAkEGVVAAA
1 0 K12‑sm MkGLSkAkEGVVAAA
0 1 K21‑ub GVVAAAEkTkQGVAE
1 0 K21‑sm GVVAAAEkTkQGVAE
0 3 K23‑ub VAAAEkTkQGVAEAA
1 0 K23‑sm VAAAEkTkQGVAEAA
1 0 K34‑sm AEAAGKTkEGVLyVG
3 12 Y39‑p KTkEGVLyVGsKTkE
0 5 S42‑p EGVLyVGsKTkEGVV
0 2 K43 GVLyVGsKTkEGVVH
0 1 K45 LyVGsKTKEGVVHGV
0 1 K45 LyVGsKTKEGVVHGV
1 0 K45‑sm LyVGsKTkEGVVHGV
0 1 T54 GVVHGVATVAEkTkE
0 1 T54‑ga GVVHGVAtVAEkTkE
0 1 K58‑ac GVAtVAEkTkEQVTN
0 1 T59 VAtVAEkTkEQVTNV
1 0 K60‑sm AtVAEkTkEQVTNVG
1 1 T72 NVGGAVVTGVTAVAQ
1 0 K80‑sm GVTAVAQkTVEGAGs
5 1 S87‑p kTVEGAGsIAAATGF
0 1 S87‑gl kTVEGAGsIAAATGF
0 1 K96‑ac AAATGFVkKDQLGkN
0 1 K96 AAATGFVKKDQLGkN
3 0 K96‑sm AAATGFVkKDQLGkN
3 0 K102‑sm VkKDQLGkNEEGAPQ
7 0 Y125‑p VDPDNEAyEMPsEEG
39 3 S129‑p NEAyEMPsEEGyQDy
2 0 Y133‑p EMPsEEGyQDyEPEA
2 0 Y136‑p sEEGyQDyEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
  mouse

 
K6 __MDVFMKGLSKAkE
K6‑ub __MDVFMkGLSKAkE
K6 __MDVFMKGLSKAkE
K10 VFMkGLSKAkEGVVA
K12‑m1 MkGLSKAkEGVVAAA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39‑p KTKEGVLyVGsKTkE
S42‑p EGVLyVGsKTkEGVV
K43 GVLyVGsKTkEGVVH
K45 LyVGsKTKEGVVHGV
K45‑m1 LyVGsKTkEGVVHGV
K45 LyVGsKTKEGVVHGV
T54‑gl GVVHGVTtVAEKtKE
T54 GVVHGVTTVAEKtKE
K58 GVTtVAEKtKEQVTN
T59‑gl VTtVAEKtKEQVTNV
K60 TtVAEKtKEQVTNVG
T72‑gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96‑ub AAATGFVkKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VkKDQMGKGEEGYPQ
Y125 VDPGSEAYEMPsEEG
S129‑p SEAYEMPsEEGYQDY
Y133 EMPsEEGYQDYEPEA
Y136 sEEGYQDYEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
  rat

 
K6‑ac __MDVFMkGLSKAKE
K6 __MDVFMKGLSKAKE
K6 __MDVFMKGLSKAKE
K10 VFMkGLSKAKEGVVA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K12 MkGLSKAKEGVVAAA
K21 GVVAAAEKTKQGVAE
K21 GVVAAAEKTKQGVAE
K23 VAAAEKTKQGVAEAA
K23 VAAAEKTKQGVAEAA
K34 AEAAGKTKEGVLyVG
Y39‑p KTKEGVLyVGskTkE
S42‑p EGVLyVGskTkEGVV
K43‑ub GVLyVGskTkEGVVH
K45‑ac LyVGskTkEGVVHGV
K45 LyVGskTKEGVVHGV
K45 LyVGskTKEGVVHGV
T54 GVVHGVTTVAEKTKE
T54 GVVHGVTTVAEKTKE
K58 GVTTVAEKTKEQVTN
T59 VTTVAEKTKEQVTNV
K60 TTVAEKTKEQVTNVG
T72‑gl NVGGAVVtGVTAVAQ
K80 GVTAVAQKTVEGAGN
N87 KTVEGAGNIAAATGF
N87 KTVEGAGNIAAATGF
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K96 AAATGFVKKDQMGKG
K102 VKKDQMGKGEEGYPQ
Y125 VDPSSEAYEMPSEEG
S129 SEAYEMPSEEGYQDY
Y133 EMPSEEGYQDYEPEA
Y136 SEEGYQDYEPEA___
23706 : Phospho-alpha-Synuclein (Ser129) (D1R1R) Rabbit mAb
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