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ICF45
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Belongs to the tRNA(His) guanylyltransferase family. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 2.7.7.79; Mitochondrial; Transferase |
| Chromosomal Location of Human Ortholog: 5q33.3 |
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Cellular Component: cytosol; mitochondrion
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Molecular Function: ATP binding; GTP binding; identical protein binding; magnesium ion binding; nucleotidyltransferase activity; protein binding; tRNA binding; tRNA guanylyltransferase activity
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Biological Process: protein homotetramerization; tRNA modification; tRNA processing
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Reference #:
Q9NWX6
(UniProtKB)
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Alt. Names/Synonyms: FLJ11601; FLJ20546; ICF45; Interphase cytoplasmic foci protein 45; Probable tRNA(His) guanylyltransferase; THG1; THG1L; tRNA-histidine guanylyltransferase; tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
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Gene Symbols: THG1L
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Molecular weight:
34,831 Da
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Basal Isoelectric point:
8.12
Predict pI for various phosphorylation states
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