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Protein Page:
PDCD1LG2 (human)

Overview
PDCD1LG2 Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: endomembrane system; integral to membrane; plasma membrane
Biological Process: immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; positive regulation of T cell proliferation; T cell costimulation
Reference #:  Q9BQ51 (UniProtKB)
Alt. Names/Synonyms: B7-DC; B7DC; bA574F11.2; Btdc; Butyrophilin B7-DC; CD273; MGC142238; MGC142240; PD-1 ligand 2; PD-1-ligand 2; PD-L2; PD1L2; PDCD1 ligand 2; PDCD1L2; PDCD1LG2; PDL2; Programmed cell death 1 ligand 2; Programmed death ligand 2
Gene Symbols: PDCD1LG2
Molecular weight: 30,957 Da
Basal Isoelectric point: 8.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PDCD1LG2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y114‑p GVAWDYKyLtLKVKA
0 1 T116‑p AWDYKyLtLKVKASY
0 1 T128‑p ASYRKINtHILKVPE
0 1 S159‑p EVSWPNVsVPANTsH
0 1 S165‑p VsVPANTsHsRTPEG
0 1 S167‑p VPANTsHsRTPEGLY
  mouse

 
Y114 GAAWDYKYLTVKVKA
T116 AWDYKYLTVKVKASY
T128 ASYMRIDTRILEVPG
S159 EVSWQNVSVPANTSH
S165 VSVPANTSHIRTPEG
I167 VPANTSHIRTPEGLY
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