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Protein Page:
TNFRSF11B (human)

TNFRSF11B Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis. Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD); also known as hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: extracellular region; extracellular space; integral to plasma membrane; plasma membrane
Molecular Function: cytokine activity; receptor activity; tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; positive regulation of MAPKKK cascade; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; skeletal development; tumor necrosis factor-mediated signaling pathway
Disease: Paget Disease, Juvenile
Reference #:  O00300 (UniProtKB)
Alt. Names/Synonyms: MGC29565; OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; TNFRSF11B; TR1; TR11B; Tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b
Gene Symbols: TNFRSF11B
Molecular weight: 46,026 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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