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Protein Page:
NDUFA8 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NDUFA8 Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I NDUFA8 subunit family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase; Mitochondrial; EC 1.6.99.3; EC 1.6.5.3; Energy Metabolism - oxidative phosphorylation
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component: mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial respiratory chain complex I; mitochondrion
Molecular Function: protein complex binding
Biological Process: mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly
Reference #:  P51970 (UniProtKB)
Alt. Names/Synonyms: CI-19kD; CI-PGIV; Complex I-19kD; Complex I-PGIV; MGC793; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; NADH-ubiquinone oxidoreductase 19 kDa subunit; NADH:ubiquinone oxidoreductase PGIV subunit; NDUA8; NDUFA8; PGIV
Gene Symbols: NDUFA8
Molecular weight: 20,105 Da
Basal Isoelectric point: 7.58  Predict pI for various phosphorylation states
Select Structure to View Below

NDUFA8

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 K14‑ub LPTLEELkVDEVkIS
0 1 K14 LPTLEELKVDEVkIS
0 4 K19‑ub ELkVDEVkISSAVLK
0 1 S22 VDEVkISSAVLKAAA
0 2 K38‑ub HYGAQCDkPNKEFML
0 1 K38‑ac HYGAQCDkPNKEFML
0 3 K61‑ub RRCLEEGkLVNkCAL
0 4 K65‑ub EEGkLVNkCALDFFR
0 17 K102‑ub QLFRHCRkQQAkFDE
0 101 K106‑ub HCRkQQAkFDECVLD
0 2 K127‑ub PDLGELSkVTKVKTD
0 1 K132 LSkVTKVKTDRPLPE
0 35 Y142‑p RPLPENPyHSRPRPD
0 5 S151‑p SRPRPDPsPEIEGDL
0 1 Q159 PEIEGDLQPATHGSR
0 1 S165 LQPATHGSRFyFWTK
0 1 Y168‑p ATHGSRFyFWTK___
0 1 T171 GSRFyFWTK______
  mouse

 
K14 LPTLEELKVEEVKVS
K14‑sc LPTLEELkVEEVKVS
K19 ELkVEEVKVSSAVLK
S22 VEEVKVSSAVLKAAA
K38 HYGAQCDKTNKEFML
K38 HYGAQCDKTNKEFML
K61 RRCLKEGKLVNGCAL
G65 KEGKLVNGCALNFFR
Q102 QLFRHCRQQQAkFDQ
K106‑ub HCRQQQAkFDQCVLD
K127 PDLGQLSKVTKVkTD
K132‑sc LSKVTKVkTDRPLPE
Y142‑p RPLPENPyHSRARPE
N151 SRARPEPNPVIEGDL
K159 PVIEGDLKPAKHGtR
T165‑p LKPAKHGtRFFFWtV
F168 AKHGtRFFFWtV___
T171‑p GtRFFFWtV______
  rat

 
S31 LPLRSLLSLVMVKVS
S31 LPLRSLLSLVMVKVS
K36 LLSLVMVKVSsAVLK
S39‑p LVMVKVSsAVLKAAA
K55 HYGAQCDKTNKEFML
K55 HYGAQCDKTNKEFML
K78 RRCLKEGKLVNGCAL
G82 KEGKLVNGCALNFFR
K119 QLFRHCRKQQAKFDE
K123 HCRKQQAKFDECVLD
K144 PDLGELSKVTKVKTD
K149 LSKVTKVKTDRPLPE
Y159 RPLPENPYHSRPRPE
S168 SRPRPEPSPVIEGDL
K176‑ac PVIEGDLkPAKHGSR
S182 LkPAKHGSRFFFWNV
F185 AKHGSRFFFWNV___
N188 GSRFFFWNV______
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