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Protein Page:
TMED9 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TMED9 Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. Belongs to the EMP24/GP25L family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; trans-Golgi network transport vesicle; transport vesicle
Molecular Function: protein binding; syntaxin binding
Biological Process: COPI coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; protein exit from endoplasmic reticulum; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  Q9BVK6 (UniProtKB)
Alt. Names/Synonyms: Glycoprotein 25L2; GP25L2; gp25L2 protein; HSGP25L2G; TMED9; Transmembrane emp24 domain-containing protein 9; transmembrane emp24 protein transport domain containing 9
Gene Symbols: TMED9
Molecular weight: 27,277 Da
Basal Isoelectric point: 7.81  Predict pI for various phosphorylation states
Select Structure to View Below

TMED9

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment



 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 K71‑ub YRTQLYDkQREEYQP
0 1 T80‑p REEYQPAtPGLGMFV
0 1 K90‑ub LGMFVEVkDPEDKVI
0 1 Y152‑p VGEHANDyAEIAAkD
0 1 K158‑ub DyAEIAAkDkLSELQ
0 5 K160‑ub AEIAAkDkLSELQLR
0 72 K180‑ub EQVEQIQkEQNYQRW
0 1 S198‑p RFRQTSEsTNQRVLW
0 4 K226‑ub VWQMRHLkSFFEAkK
0 2 K232‑ub LkSFFEAkKLV____
  mouse

 
K71 YRTQLYDKQREEYQP
T80 REEYQPATPGLGMFV
K90 LGMFVEVKDPEDKVI
Y152 VGEHANDYAEIAAKD
K158 DYAEIAAKDKLSELQ
K160 AEIAAKDKLSELQLR
K180‑ub EQVEQIQkEQNYQRW
S198 RFRQTSESTNQRVLW
K226 VWQMRHLKSFFEAKK
K232 LKSFFEAKKLV____
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