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Protein Page:
HIST2H2AB (human)

HIST2H2AB Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: nuclear chromatin; nucleus
Molecular Function: DNA binding
Biological Process: chromatin silencing
Reference #:  Q8IUE6 (UniProtKB)
Alt. Names/Synonyms: H2A2B; HIST2H2AB; histone 2, H2ab; histone cluster 2, H2ab; Histone H2A type 2-B
Gene Symbols: HIST2H2AB
Molecular weight: 13,995 Da
Basal Isoelectric point: 10.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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