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ADAM8
Possible involvement in extravasation of leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease |
| Chromosomal Location of Human Ortholog: 10q26.3 |
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Cellular Component: cell surface; cytoplasm; dense core granule membrane; integral to plasma membrane; plasma membrane; podosome; specific granule
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Molecular Function: calcium ion binding; cell adhesion molecule binding; metallopeptidase activity; protein binding; protein self-association; serine-type endopeptidase activity; zinc ion binding
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Biological Process: activation of NF-kappaB transcription factor; angiogenesis; cell morphogenesis; extracellular matrix disassembly; inflammatory response; leukocyte migration during inflammatory response; lymphocyte chemotaxis; negative regulation of neuron apoptosis; neutrophil degranulation; positive regulation of acute inflammatory response; positive regulation of bone resorption; positive regulation of cell adhesion; positive regulation of membrane protein ectodomain proteolysis; positive regulation of protein kinase B signaling cascade; positive regulation of protein secretion; positive regulation of T cell differentiation in the thymus; regulation of cell-cell adhesion
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Reference #:
P78325
(UniProtKB)
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Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 8; ADAM 8; ADAM metallopeptidase domain 8; ADAM8; CD156; Cell surface antigen MS2; Disintegrin and metalloproteinase domain-containing protein 8; human leukocyte differentiation antigen; MGC134985; MS2
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Gene Symbols: ADAM8
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Molecular weight:
88,771 Da
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Basal Isoelectric point:
7.63
Predict pI for various phosphorylation states
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