a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. May mediate TGF beta-induced g1 arrest. Its degradation is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein kinase inhibitor activity; protein binding; protein complex binding; protein kinase binding; protein kinase inhibitor activity; protein phosphatase binding; transforming growth factor beta receptor, cytoplasmic mediator activity
Biological Process: autophagic cell death; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G1/S transition of mitotic cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of kinase activity; negative regulation of mitotic cell cycle; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of cell cycle; positive regulation of protein catabolic process; regulation of cyclin-dependent protein kinase activity