|
BAK1
In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. Interacts with BCL2A1. Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle. Belongs to the Bcl-2 family. Note: This description may include information from UniProtKB.
|
| Protein type: Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial |
| Chromosomal Location of Human Ortholog: 17|17 A3.3 |
|
Cellular Component: cytosol; endoplasmic reticulum; integral to mitochondrial outer membrane; intracellular; membrane; mitochondrial membrane; mitochondrion; pore complex
|
|
Molecular Function: BH domain binding; chaperone binding; heat shock protein binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity
|
|
Biological Process: apoptosis; B cell apoptosis; B cell homeostasis; B cell negative selection; blood vessel remodeling; caspase activation; caspase activation via cytochrome c; cell proliferation; cytolysis; DNA damage response, signal transduction resulting in induction of apoptosis; establishment and/or maintenance of transmembrane electrochemical gradient; homeostasis of number of cells; leukocyte homeostasis; limb morphogenesis; mitochondrial fusion; myeloid cell homeostasis; negative regulation of cell proliferation; negative regulation of peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of proteolysis; post-embryonic camera-type eye morphogenesis; reduction of endoplasmic reticulum calcium ion concentration; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; regulation of protein heterodimerization activity; regulation of protein homodimerization activity; release of cytochrome c from mitochondria; response to fungus; response to gamma radiation; response to mycotoxin; vagina development
|
|
Reference #:
O08734
(UniProtKB)
|
|
Alt. Names/Synonyms: Apoptosis regulator BAK; Bak; Bak1; Bcl-2 homologous antagonist/killer; Bcl2 homologous antagonist/killer; BCL2-antagonist/killer 1; N-Bak; N-BAK1
|
|
Gene Symbols: Bak1
|
|
Molecular weight:
23,295 Da
|
|
Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
|
|
CST Pathways:
Apoptosis Regulation
|
Mitochondrial Control of Apoptosis
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
