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Protein Page:
CLEC4E (human)

Overview
CLEC4E C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: plasma membrane
Biological Process: stimulatory C-type lectin receptor signaling pathway
Reference #:  Q9ULY5 (UniProtKB)
Alt. Names/Synonyms: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9; C-type lectin domain family 4 member E; C-type lectin domain family 4, member E; C-type lectin superfamily member 9; CLC4E; CLEC4E; CLECSF9; Macrophage-inducible C-type lectin; MINCLE
Gene Symbols: CLEC4E
Molecular weight: 25,073 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Select Structure to View Below

CLEC4E

Protein Structure Not Found.
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