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Protein Page:
WFS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
WFS1 Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 4p16.1
Cellular Component: dendrite; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; proteasome complex
Molecular Function: ATPase binding; protein binding; transcription activator binding; ubiquitin protein ligase binding
Biological Process: calcium ion homeostasis; cellular protein metabolic process; endoplasmic reticulum calcium ion homeostasis; ER overload response; ER-associated protein catabolic process; glucose homeostasis; kidney development; negative regulation of neuron apoptosis; negative regulation of programmed cell death; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; neurological system process; positive regulation of adenylate cyclase activity; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein maturation via protein folding; protein stabilization; renal water homeostasis; sensory perception of sound; unfolded protein response; visual perception
Disease: Cataract 41; Deafness, Autosomal Dominant 6; Diabetes Mellitus, Noninsulin-dependent; Wolfram Syndrome 1; Wolfram-like Syndrome, Autosomal Dominant
Reference #:  O76024 (UniProtKB)
Alt. Names/Synonyms: FLJ51211; WFRS; WFS; WFS1; Wolfram syndrome 1 (wolframin); Wolframin
Gene Symbols: WFS1
Molecular weight: 100,292 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

WFS1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 T5 ___MDSNTAPLGPSC
0 1 G9 DSNTAPLGPSCPQPP
0 2 S11 NTAPLGPSCPQPPPA
0 1 S25‑p APQPQARsRLNAtAs
0 1 T30‑p ARsRLNAtAsLEQER
0 18 S32‑p sRLNAtAsLEQERSE
0 1 K108 KAQTEVGKHYLQLAG
0 1 K143 QGRREAVKLLRRCLA
0 8 S157 ADRRGITSENEREVR
1 128 S235‑p RMLERLVssEsKNyI
1 22 S236‑p MLERLVssEsKNyIA
0 3 S238‑p ERLVssEsKNyIALD
0 1 Y241‑p VssEsKNyIALDDFV
0 1 K252‑ub DDFVEITkKYAkGVI
0 1 K256‑ub EITkKYAkGVIPSSL
0 1 K277‑ub DDDELAGksPEDLPL
0 1 S278‑p DDELAGksPEDLPLR
0 1 K369‑ub LKVFQDSkAWENFRT
0 2 S619 WWTKASFSVVGMVKS
0 1 S626 SVVGMVKSLTRssMV
0 1 T628 VGMVKSLTRssMVKL
0 1 S630‑p MVKSLTRssMVKLIL
0 1 S631‑p VKSLTRssMVKLILV
0 1 K679‑ub LCGPRAWkETNMART
0 1 T778 DRYKFEITVGMPFSS
0 2 S785 TVGMPFSSGADGSRs
0 1 S792‑p SGADGSRsREEDDVt
0 2 T799‑p sREEDDVtkDIVLRA
0 4 K800‑ub REEDDVtkDIVLRAS
0 1 K811‑ub LRASSEFkSVLLSLR
0 1 K836‑ub LEGRLGSkWPVFELK
  mouse

 
T5‑p ___MNSGtPPPsPsG
S9‑p NSGtPPPsPsGPPPP
S11‑p GtPPPsPsGPPPPPA
A25 APQPQARARLNATAs
T30 ARARLNATAsLEQDK
S32‑p ARLNATAsLEQDKIE
K109‑ac KAQTEVGkHYLRLAN
K144 QGRREAVKLLRRCLA
S158‑p ADRKGITsENEAEVK
S236‑p RMLERLVssEsKNYI
S237‑p MLERLVssEsKNYIA
S239‑p ERLVssEsKNYIALD
Y242 VssEsKNYIALDDFV
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPTNL
K279 DEDELAGKSPEDLPL
S280 EDELAGKSPEDLPLR
K371 LKVFQDSKAWENFRT
S621‑p WWTKANFsVMGMVKs
S628‑p sVMGMVKsLtKSSMV
T630‑p MGMVKsLtKSSMVKL
S632 MVKsLtKSSMVKLIL
S633 VKsLtKSSMVKLILV
K681 LCGPRAWKETNMART
T780‑p DRYKFEItVGMPFGt
T787‑p tVGMPFGtNGNRGHE
G792 FGtNGNRGHEEDDIT
T799 GHEEDDITKDIVLRA
K800 HEEDDITKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
  rat

 
T5‑p ___MSSGtPPPSPSG
S9 SSGtPPPSPSGPPPP
S11 GtPPPSPSGPPPPPA
A25 APQPQARARLNATTs
T30 ARARLNATTsLEQDK
S32‑p ARLNATTsLEQDKIE
K109 KAQTEVGKHYLRLAN
K144‑ac QGRREAVkLLRRCLA
S158‑p ADRKGITsENEAEVK
S236 RMLERLVSSESKNYI
S237 MLERLVSSESKNYIA
S239 ERLVSSESKNYIALD
Y242 VSSESKNYIALDDFV
K253 DDFVELTKKYAKGII
K257 ELTKKYAKGIIPNNL
K279 DEDELSGKSPEDLPL
S280 EDELSGKSPEDLPLR
K371 LKVFQDSKAWENFRT
S621 WWTKANFSVVGMVKS
S628 SVVGMVKSLTRSSIV
T630 VGMVKSLTRSSIVKL
S632 MVKSLTRSSIVKLIL
S633 VKSLTRSSIVKLILV
K681 LCGPRAWKETNMART
T780 DRYKFEITVGMPFGt
T787‑p TVGMPFGtNGNRGHE
G792 FGtNGNRGHEEDDIt
T799‑p GHEEDDItKDIVLRA
K800 HEEDDItKDIVLRAS
K811 LRASSEFKDVLLNLR
K836 LEGRLGSKWPVFELK
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