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MMP2
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Interacts (via the C-terminal hemopexin-like domains- containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B. Aspirin appears to inhibit expression. Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. Inhibited by histatin-3 1/24 (histatin-5). Belongs to the peptidase M10A family. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cell development/differentiation; EC 3.4.24.24; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 16q12.2 |
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Cellular Component: extracellular matrix; extracellular region; extracellular space
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Molecular Function: metalloendopeptidase activity; metallopeptidase activity; protein binding; serine-type endopeptidase activity
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Biological Process: cellular protein metabolic process; collagen catabolic process; ephrin receptor signaling pathway; extracellular matrix disassembly; proteolysis
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Disease: Multicentric Osteolysis, Nodulosis, And Arthropathy
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Reference #:
P08253
(UniProtKB)
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Alt. Names/Synonyms: 72 kDa gelatinase; 72 kDa type IV collagenase; CLG4; CLG4A; collagenase type IV-A; Gelatinase A; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Matrix metalloproteinase-2; matrix metalloproteinase-II; MMP-2; MMP-II; MMP2; MONA; neutrophil gelatinase; PEX; TBE-1
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Gene Symbols: MMP2
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Molecular weight:
73,882 Da
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Basal Isoelectric point:
5.26
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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GPCR Signaling to MAPKs
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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