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Protein Page:
MEF2C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEF2C transcription factor of the MADS family which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in myogenesis, neurogenesis and in the development of cortical architecture. Three splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Chromosomal Location of Human Ortholog: 5q14.3
Cellular Component: nucleoplasm; sarcomere; protein complex; cytoplasm; nuclear speck; cytosol; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; miRNA binding; DNA binding; transcription activator binding; AT DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; transcription factor activity
Biological Process: cardiac muscle hypertrophy; muscle development; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; heart development; regulation of neurotransmitter secretion; stress-activated MAPK cascade; regulation of synaptic plasticity; toll-like receptor 3 signaling pathway; neuron differentiation; toll-like receptor 5 signaling pathway; positive regulation of MAP kinase activity; B cell receptor signaling pathway; response to vitamin E; regulation of neuron apoptosis; positive regulation of B cell proliferation; negative regulation of ossification; chondrocyte differentiation; negative regulation of neuron apoptosis; toll-like receptor 4 signaling pathway; positive regulation of cardiac muscle cell proliferation; endochondral ossification; nervous system development; skeletal muscle development; dentate gyrus development; monocyte differentiation; response to virus; myotube differentiation; positive regulation of skeletal muscle development; muscle cell fate determination; toll-like receptor 2 signaling pathway; muscle cell differentiation; regulation of synaptogenesis; neuron development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; toll-like receptor 9 signaling pathway; transcription from RNA polymerase II promoter; B cell proliferation; regulation of synaptic transmission, glutamatergic; apoptosis; neuron migration; ventricular cardiac muscle cell differentiation; regulation of synaptic activity; negative regulation of transcription from RNA polymerase II promoter; palate development; toll-like receptor 10 signaling pathway; learning and/or memory; regulation of transcription, DNA-dependent; B cell homeostasis; regulation of megakaryocyte differentiation; melanocyte differentiation; germinal center formation; heart looping; neural crest cell differentiation; negative regulation of epithelial cell proliferation; blood vessel development; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; embryonic viscerocranium morphogenesis; positive regulation of bone mineralization; positive regulation of myoblast differentiation; regulation of germinal center formation; humoral immune response; osteoblast differentiation; MyD88-dependent toll-like receptor signaling pathway; positive regulation of osteoblast differentiation; neuron morphogenesis during differentiation; toll-like receptor signaling pathway; positive regulation of muscle cell differentiation; innate immune response; blood vessel remodeling; platelet formation; regulation of excitatory postsynaptic membrane potential; positive regulation of neuron differentiation
Reference #:  Q06413 (UniProtKB)
Alt. Names/Synonyms: MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); MEF2C; myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C
Gene Symbols: MEF2C
Molecular weight: 51,221 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEF2C

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S396‑p
transcription, inhibited: K391‑sm
protein processing: S396‑p
sumoylation: S396‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 K4 ____MGRKKIQITRI
1 0 T20 DERNRQVTFTKRKFG
1 0 S59 NKLFQYASTDMDKVL
1 0 T80-p NEPHESRtNsDIVET
0 2 S82-p PHESRtNsDIVETLR
0 2 - gap
0 4 - gap
0 1 - gap
0 5 - gap
1 9 S98-p KGLNGCDsPDPDADD
0 4 S106-p PDPDADDsVGHsPES
1 6 S110-p ADDsVGHsPESEDkY
1 0 K116-ac HsPESEDkYRkINED
1 0 K119-ac ESEDkYRkINEDIDL
1 1 S183 SLQRNSMSPGVTHRP
0 1 S192 GVTHRPPSAGNTGGL
0 1 S206 LMGGDLTSGAGTSAG
0 19 S222-p GYGNPRNsPGLLVsP
0 7 S228-p NsPGLLVsPGNLNkN
1 0 K234-ac VsPGNLNkNMQAksP
1 0 K239-ac LNkNMQAksPPPMNL
1 11 S240-p NkNMQAksPPPMNLG
0 1 R251 MNLGMNNRkPDLRVL
1 0 K252-ac NLGMNNRkPDLRVLI
1 0 K264-ac VLIPPGSkNTMPSVS
1 0 T293 QSAQSLATPVVSVAT
1 0 T300 TPVVSVATPTLPGQG
1 0 K391-sm STQSLNIkSEPVsPP
3 6 S396-p NIkSEPVsPPRDRTT
2 0 S419-p TRHEAGRsPVDSLSS
0 1 S445-p DHRNEFHsPIGLTRP
0 2 S461-p PDERESPsVKRMRLS
0 1 S468 sVKRMRLSEGWAT__
  MEF2C iso3  
K4 ____MGRKKIQITRI
T20 DERNRQVTFTKRKFG
S59 NKLFQYASTDMDKVL
T80 NEPHESRTNSDIVET
S82 PHESRTNSDIVETLR
- gap
- gap
- gap
- gap
S98 KGLNGCDSPDPDADD
S106 PDPDADDSVGHSPES
S110 ADDSVGHSPESEDKY
K116 HSPESEDKYRKINED
K119 ESEDKYRKINEDIDL
S183 SLQRNSMSPGVTHRP
S192 GVTHRPPSAGNTGGL
S206 LMGGDLTSGAGTSAG
S222 GYGNPRNSPGLLVSP
S228 NSPGLLVSPGNLNKN
K234 VSPGNLNKNMQAKSP
K239 LNKNMQAKSPPPMNL
S240 NKNMQAKSPPPMNLG
R251 MNLGMNNRKPDLRVL
K252 NLGMNNRKPDLRVLI
K264 VLIPPGSKNTMPSVS
T293-p QSAQSLAtPVVSVAt
T300-p tPVVSVAtPTLPGQG
- gap
- gap
S387-p TRHEAGRsPVDSLSS
S413 DHRNEFHSPIGLTRP
S429 PDERESPSVKRMRLS
S436 SVKRMRLSEGWAT__
  MEF2C iso6  
K4 ____MGRKKIQITRI
T20 DERNRQVTFTKRKFG
S59 NKLFQYASTDMDKVL
T80 NEPHESRTNSDIVEA
S82 PHESRTNSDIVEALN
C96 NKKENKGCEsPDPDS
S98-p KENKGCEsPDPDSSy
Y105-p sPDPDSSyALtPRTE
T108-p PDSSyALtPRTEEKY
- gap
- gap
- gap
K114 LtPRTEEKYKKINEE
K117 RTEEKYKKINEEFDN
S181 SLQRNSMSPGVTHRP
S190 GVTHRPPSAGNTGGL
S204 LMGGDLTSGAGTSAG
S220 GYGNPRNSPGLLVSP
S226 NSPGLLVSPGNLNKN
K232 VSPGNLNKNMQAKSP
K237 LNKNMQAKSPPPMNL
S238 NKNMQAKSPPPMNLG
R249 MNLGMNNRKPDLRVL
K250 NLGMNNRKPDLRVLI
K262 VLIPPGSKNTMPSVN
T283 QSAQSLATPVVSVAT
T290 TPVVSVATPTLPGQG
K381 STQSLNIKSEPVSPP
S386 NIKSEPVSPPRDRTT
S409 TRHEAGRSPVDSLSS
S435 DHRNEFHSPIGLTRP
S451 PDERESPSVKRMRLS
S458 SVKRMRLSEGWAT__
  mouse

► Hide Isoforms
 
K4-ac ____MGRkKIQITRI
T20-p DERNRQVtFTKRKFG
S59-p NKLFQYAsTDMDKVL
T80 NEPHESRTNsDIVET
S82-p PHESRTNsDIVETLR
- gap
- gap
- gap
- gap
S98-p KGLNGCDsPDPDADD
S106-p PDPDADDsVGHsPES
S110-p ADDsVGHsPESEDKY
K116 HsPESEDKYRKINED
K119 ESEDKYRKINEDIDL
S183-p SLQRNSMsPGVTHRP
S192-p GVTHRPPsAGNTGGL
S206-p LMGGDLTsGAGTSAG
S222-p GYGNPRNsPGLLVsP
S228-p NsPGLLVsPGNLNKN
K234 VsPGNLNKNIQAKsP
K239 LNKNIQAKsPPPMNL
S240-p NKNIQAKsPPPMNLG
R251-m1 MNLGMNNrKPDLRVL
K252 NLGMNNrKPDLRVLI
K264 VLIPPGSKNTMPSVS
T293 QSAQSLATPVVSVAT
T300 TPVVSVATPTLPGQG
K391 STQSLSIKSEPVsPP
S396-p SIKSEPVsPPRDRTT
S420 TRHEAGRSPVDSLSS
S446 DHRNEFHSPIGLTRP
S462-p PDERESPsVKRMRLs
S469-p sVKRMRLsEGWAT__
  MEF2C iso4  
K4 ____MGRKKIQITRI
T20 DERNRQVTFTKRKFG
S59 NKLFQYASTDMDKVL
T80 NEPHESRTNSDIVEA
S82 PHESRTNSDIVEALN
S96-p NKKENKGsEsPDPDS
S98-p KENKGsEsPDPDSSY
Y105 sPDPDSSYALtPRTE
T108-p PDSSYALtPRTEEKY
- gap
- gap
- gap
K114 LtPRTEEKYKKINEE
K117 RTEEKYKKINEEFDN
S181 SLQRNSMSPGVTHRP
S190 GVTHRPPSAGNTGGL
S204 LMGGDLTSGAGTSAG
S220 GYGNPRNSPGLLVSP
S226 NSPGLLVSPGNLNKN
K232 VSPGNLNKNIQAKSP
K237 LNKNIQAKSPPPMNL
S238 NKNIQAKSPPPMNLG
R249 MNLGMNNRKPDLRVL
K250 NLGMNNRKPDLRVLI
K262 VLIPPGSKNTMPSVN
T283 QSAQSLATPVVSVAT
T290 TPVVSVATPTLPGQG
- gap
- gap
S378 TRHEAGRSPVDSLSS
S404 DHRNEFHSPIGLTRP
S420 PDERESPSVKRMRLS
S427 SVKRMRLSEGWAT__
  rat

 
K4 ____MGRKKIQITRI
T20 DERNRQVTFTKRKFG
S59 NKLFQYASTDMDKVL
T80 NEPHESRTNSDIVEA
S82 PHESRTNSDIVEALN
C96 NKKEHRGCDsPDPDT
S98-p KEHRGCDsPDPDTSY
Y105 sPDPDTSYVLTPHTE
T108 PDTSYVLTPHTEEKY
- gap
- gap
- gap
K114 LTPHTEEKYKKINEE
K117 HTEEKYKKINEEFDN
S192-p ATLHRNVsPGAPQRP
S201 GAPQRPPSTGSAGGM
- gap
S235-p GFVDSRAsPNLIGNT
N241 AsPNLIGNTGANSVG
K249-ac TGANSVGkVMPTKsP
K254 VGkVMPTKsPPPPGG
S255-p GkVMPTKsPPPPGGG
R269 GSVGMNSRKPDLRVV
K270 SVGMNSRKPDLRVVI
K282 VVIPPSSKGMMPPLN
T304 QATQPLATPVVSVTT
T311 TPVVSVTTPSLPPQG
K395 TNQNINIKTEPISPP
S400 NIKTEPISPPRDRMT
S441 PRQEMGRSPVDSLSS
S467 DPRGDFHSPIVLGRP
S484 AEDRESPSVKRMRMD
- gap
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