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Protein Page:
MEF2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MEF2A a myocyte-specific enhancing transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many, if not all, muscle-specific genes. A member of the MADS gene family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain. Five alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 15q26
Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; nucleolus; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein binding; transcription activator binding; sequence-specific DNA binding; protein heterodimerization activity; histone deacetylase binding; chromatin binding; SMAD binding; transcription factor activity; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; muscle development; nerve growth factor receptor signaling pathway; ventricular cardiac myofibril development; apoptosis; heart development; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; mitochondrial genome maintenance; toll-like receptor 4 signaling pathway; transcription, DNA-dependent; dendrite morphogenesis; MyD88-independent toll-like receptor signaling pathway; MAPKKK cascade; mitochondrion distribution; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway
Reference #:  Q02078 (UniProtKB)
Alt. Names/Synonyms: ADCAD1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A); MEF2; MEF2A; myocyte enhancer factor 2A; Myocyte-specific enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor-like protein 1
Gene Symbols: MEF2A
Molecular weight: 54,811 Da
Basal Isoelectric point: 7.72  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Crosstalk between PTMs  |  ErbB/HER Signaling  |  Regulation of P38 MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MEF2A

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: T312‑p, T319‑p, S408‑p
transcription, induced: S408‑p
activity, induced: T312‑p, T319‑p, S355‑p
protein degradation: S255‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 0 S59-p NKLFQYAsTDMDKVL
0 2 S82 PHESRTNSDIVEALN
0 23 S98-p KEHRGCDsPDPDtsy
0 3 T103-p CDsPDPDtsyVLtPH
0 1 S104-p DsPDPDtsyVLtPHt
0 2 Y105-p sPDPDtsyVLtPHtE
0 16 T108-p PDtsyVLtPHtEEKy
0 4 T111-p syVLtPHtEEKyKKI
0 1 Y115-p tPHtEEKyKKINEEF
0 1 R127 EEFDNMMRNHKIAPG
0 1 S192-p TTLHRNVsPGAPQRP
0 1 S210 GNAGGMLSTTDLTVP
0 1 S223-p VPNGAGSsPVGNGFV
0 14 S235-p GFVNSRAsPNLIGAT
0 1 S246-p IGATGANsLGkVMPt
0 2 K249-ac TGANsLGkVMPtKsP
0 1 T253-p sLGkVMPtKsPPPPG
1 10 S255-p GkVMPtKsPPPPGGG
0 1 S289-p KGMMPPLsEEEELEL
2 0 T312-p QATQPLAtPVVSVTt
2 0 T319-p tPVVSVTtPSLPPQG
1 0 S355-p SALQGFNsPGMLSLG
1 0 K403-ac TNQNISIkSEPIsPP
2 0 K403-sm TNQNISIkSEPIsPP
3 5 S408-p SIkSEPIsPPRDRMT
0 1 T415 sPPRDRMTPSGFQQQ
0 1 S457-p MGRSPVDsLSSSSSS
0 12 S479-p DPRGDFHsPIVLGRP
0 3 S494-p PNTEDREsPSVKRMR
9737 : Phospho-MEF2A (Ser408) Antibody
  MEF2A iso2  
S59 NKLFQYASTDMDKVL
S82-p PHESRTNsDIVETLR
S98-p KGLNGCEsPDADDYF
D103 CEsPDADDYFEHsPL
Y104 EsPDADDYFEHsPLS
F105 sPDADDYFEHsPLSE
S108-p ADDYFEHsPLSEDRF
S111 YFEHsPLSEDRFSKL
F115 sPLSEDRFSKLNEDS
K127-ub EDSDFIFkRGPPGLP
S190 TTLHRNVSPGAPQRP
S208 GNAGGMLSTTDLTVP
S221 VPNGAGSSPVGNGFV
S233 GFVNSRASPNLIGAT
S244 IGATGANSLGKVMPT
K247 TGANSLGKVMPTKSP
T251 SLGKVMPTKSPPPPG
S253 GKVMPTKSPPPPGGG
S287 KGMMPPLSEEEELEL
T310 QATQPLATPVVSVTT
T317 TPVVSVTTPSLPPQG
S353 SALQGFNSPGMLSLG
K401 TNQNISIKSEPISPP
K401 TNQNISIKSEPISPP
S406 SIKSEPISPPRDRMT
T413 SPPRDRMTPSGFQQQ
S455 MGRSPVDSLSSSSSS
S477 DPRGDFHSPIVLGRP
S492 PNTEDRESPSVKRMR
  mouse

► Hide Isoforms
 
S59 NKLFQYASTDMDKVL
S82-p PHESRTNsDIVETLR
S98-p KGLNGCEsPDADDyF
D103 CEsPDADDyFEHsPL
Y104-p EsPDADDyFEHsPLs
F105 sPDADDyFEHsPLsE
S108-p ADDyFEHsPLsEDRF
S111-p yFEHsPLsEDRFSKL
F115 sPLsEDRFSKLNEDS
K127 EDSDFIFKRGPPGLP
S190 ATLHRNVSPGAPQRP
S208-p GSASGMLsTTDLTVP
S221 VPNGAGNSPVGNGFV
S233-p GFVNSRAsPNLIGNT
S244 IGNTGANSLGKVMPT
K247 TGANSLGKVMPTKsP
T251 SLGKVMPTKsPPPPG
S253-p GKVMPTKsPPPPGGG
S287 KGMMPPLSEEEELEL
T310 QATQPLATPVVSVTT
T317 TPVVSVTTPSLPPQG
S353 SALQGFTSPGMLSLG
K401 TNQNINIKSEPIsPP
K401 TNQNINIKSEPIsPP
S406-p NIKSEPIsPPRDRMt
T413-p sPPRDRMtPSGFQQQ
S448 MGRSPVDSLSSSSSS
S470-p DPRGDFHsPIVLGRP
S485-p PNTEDREsPSVKRMR
9737 : Phospho-MEF2A (Ser408) Antibody
  MEF2A iso3  
S59 NKLFQYASTDMDKVL
S82 PHESRTNSDIVEALN
S98-p KEHRGCDsPDPDtSy
T103-p CDsPDPDtSyVLtPH
S104 DsPDPDtSyVLtPHt
Y105-p sPDPDtSyVLtPHtE
T108-p PDtSyVLtPHtEEKY
T111-p SyVLtPHtEEKYKKI
Y115 tPHtEEKYKKINEEF
R127 EEFDNMMRNHKIAPG
S192 ATLHRNVSPGAPQRP
S210 GSASGMLSTTDLTVP
S223 VPNGAGNSPVGNGFV
S235-p GFVNSRAsPNLIGNT
S246 IGNTGANSLGKVMPT
K249 TGANSLGKVMPTKsP
T253 SLGKVMPTKsPPPPG
S255-p GKVMPTKsPPPPGGG
N289 KGMMPPLNAQRISSS
T304 QATQPLATPVVSVTT
T311 TPVVSVTTPSLPPQG
S347 SALQGFTSPGMLSLG
K395 TNQNINIKSEPISPP
K395 TNQNINIKSEPISPP
S400 NIKSEPISPPRDRMt
T407-p SPPRDRMtPSGFQQQ
S442 MGRSPVDSLSSSSSS
S464 DPRGDFHSPIVLGRP
S479-p PNTEDREsPSVKRMR
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