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IGBP1 (human)

Overview IGBP1 Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit Cellular Component: cytoplasm Molecular Function: protein binding; mitogen-activated protein kinase kinase binding; protein phosphatase type 2A regulator activity Biological Process: negative regulation of protein amino acid dephosphorylation; B cell activation; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of stress-activated MAPK cascade; signal transduction; negative regulation of apoptosis Reference #:  P78318 (UniProtKB) Alt. Names/Synonyms: ALPHA-4; B cell signal transduction molecule alpha 4; B-cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); CD79a-binding protein 1; IBP1; IGBP1; immunoglobulin (CD79A) binding protein 1; immunoglobulin binding protein 1; Immunoglobulin-binding protein 1; Protein alpha-4; protein phosphatase 2A, regulatory subunit alpha-4; Renal carcinoma antigen NY-REN-16 Gene Symbols: IGBP1 Molecular weight: 39,222 Da Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IGBP1 4IYP - A=2-234 (human) 3QC1 - A=1-223 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE 300139 300472  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		A3	_____MAAEDELQLP
0	2		K44-u	IVQEKVFkGLDLLEK
0	19		Y145-p	TANSSMAyPSLVAMA
0	1		K176-u	EHRLSAMkSAVEsGQ
0	1		S181-p	AMkSAVEsGQADDER
0	1		R225-m2	LRERDSSrEASTSNS
0	1		K241-a	RQERPPVkPFILTRN
0	1		K241-u	RQERPPVkPFILTRN
0	1		K253-u	TRNMAQAkVFGAGyP
0	1		Y259-p	AkVFGAGyPsLPtMt
0	5		S261-p	VFGAGyPsLPtMtVs
0	3		T264-p	AGyPsLPtMtVsDWy
0	3		T266-p	yPsLPtMtVsDWyEQ
0	8		S268-p	sLPtMtVsDWyEQHR
0	39		Y271-p	tMtVsDWyEQHRKyG
0	7		Y277-p	WyEQHRKyGALPDQG
0	1		K287-u	LPDQGIAkAAPEEFR
0	2		K295-u	AAPEEFRkAAQQQEE

	mouse
S4-p	____MAAsEDELLLP
K45-u	TIQDKVSkGLELLEK
Y146	TASSSMAYPNLVAMA
K177	EHRLSALKSAVESGQ
S182	ALKSAVESGQADDER
R226	LKEKDSPREETACHS
K242	LPEKPPMKPFILTRN
K242	LPEKPPMKPFILTRN
K254	TRNKAQAKVFGTGYP
Y260	AKVFGTGYPSLATMT
S262	VFGTGYPSLATMTVS
T265	TGYPSLATMTVSDWY
T267	YPSLATMTVSDWYEQ
S269	SLATMTVSDWYEQHQ
Y272	TMTVSDWYEQHQKYG
Y278	WYEQHQKYGVLPDRG
K288	LPDRGIAKPASADFQ
R296	PASADFQRAAQQQED

	rat
S4	____MAASEEELLLP
K45	TIQDKVSKGLELLEK
Y146	TARSSMAYPNLVAMA
K177	EHRLSALKSAVESGQ
S182	ALKSAVESGQADDER
R226	LKDKDSPREESACQS
K242	LPEKPPMKPFILTRN
K242	LPEKPPMKPFILTRN
K254	TRNKAQAKVFGTGYP
Y260	AKVFGTGYPSLATMT
S262	VFGTGYPSLATMTVS
T265	TGYPSLATMTVSDWY
T267	YPSLATMTVSDWYEQ
S269	SLATMTVSDWYEQHQ
Y272	TMTVSDWYEQHQKYG
Y278	WYEQHQKYGALPDRG
K288	LPDRGIAKPPSADFQ
R296	PPSADFQRAAQQQED

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