Associated to surface IgM-receptor; may be involved in signal transduction. May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Associates with PP2A-alpha and PP2A-beta catalytic subunits, and with PP4 and PP6. Interacts with MID1 and MID2. Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas. Belongs to the IGBP1/TAP42 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq13.1-q13.3
Cellular Component: cytoplasm
Molecular Function: protein binding; mitogen-activated protein kinase kinase binding; protein phosphatase type 2A regulator activity
Biological Process: negative regulation of protein amino acid dephosphorylation; B cell activation; positive regulation of dephosphorylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; negative regulation of stress-activated MAPK cascade; signal transduction
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.