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MARCKS (human)

Overview MARCKS the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Actin binding protein Cellular Component: germinal vesicle; centrosome; plasma membrane; cell cortex; actin cytoskeleton Molecular Function: actin filament binding; calmodulin binding; protein kinase C binding Biological Process: energy reserve metabolic process; regulation of insulin secretion Reference #:  P29966 (UniProtKB) Alt. Names/Synonyms: 80K-L; 80K-L protein; FLJ14368; FLJ90045; MACS; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain Gene Symbols: MARCKS Molecular weight: 31,555 Da Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states CST Pathways:  Protein Kinase C Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MARCKS 1IWQ - B=148-166 (mouse)

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	25		K11-u	QFSKTAAkGEAAAER
0	1		A15	TAAkGEAAAERPGEA
1	9		S26-p	PGEAAVAssPskANG
4	30		S27-p	GEAAVAssPskANGQ
0	16		S29-p	AAVAssPskANGQEN
0	2		K30-u	AVAssPskANGQENG
0	17		S46-p	VKVNGDAsPAAAESG
0	1		K55-u	AAAESGAkEELQANG
0	3		S63-p	EELQANGsAPAADkE
0	1		K69-u	GsAPAADkEEPAAAG
0	4		S77-p	EEPAAAGsGAAsPSA
0	7		S81-p	AAGsGAAsPSAAEkG
0	1		K87-u	AsPSAAEkGEPAAAA
0	13		S101-p	AAPEAGAsPVEkEAP
0	1		K105-u	AGAsPVEkEAPAEGE
0	4		G117	EGEAAEPGsPtAAEG
1	16		S118-p	GEAAEPGsPtAAEGE
0	4		T120-p	AAEPGsPtAAEGEAA
0	3		S128-p	AAEGEAAsAAsstss
1	3		S131-p	GEAAsAAsstssPKA
1	2		S132-p	EAAsAAsstssPKAE
1	2		T133-p	AAsAAsstssPKAED
1	3		S134-p	AsAAsstssPKAEDG
1	5		S135-p	sAAsstssPKAEDGA
0	2		T143-p	PKAEDGAtPsPsNEt
0	22		S145-p	AEDGAtPsPsNEtPk
1	15		S147-p	DGAtPsPsNEtPkkK
0	4		N148	GAtPsPsNEtPkkKK
1	35		T150-p	tPsPsNEtPkkKKKR
0	2		K152-u	sPsNEtPkkKKKRFs
0	2		K153-u	PsNEtPkkKKKRFsF
22	19		S159-p	kkKKKRFsFKKsFkL
20	22		S163-p	KRFsFKKsFkLsGFs
0	3		K165-u	FsFKKsFkLsGFsFk
5	23		S167-p	FKKsFkLsGFsFkKN
8	111		S170-p	sFkLsGFsFkKNKkE
0	20		K172-a	kLsGFsFkKNKkEAG
0	1		N174	sGFsFkKNKkEAGEG
0	1		K176-u	FsFkKNKkEAGEGGE
0	4		A178	FkKNKkEAGEGGEAE
0	2		S262-p	TKAAEEPsKVEEkKA
0	1		K267-u	EPsKVEEkKAEEAGA
0	1		S314	SSACAAPSQEAQPEC
0	1		S322	QEAQPECSPEAPPAE

	mouse
K11-u	QFSKTAAkGEAtAER
T15-p	TAAkGEAtAERPGEA
S26-p	PGEAAVAssPsKANG
S27-p	GEAAVAssPsKANGQ
S29-p	AAVAssPsKANGQEN
K30	AVAssPsKANGQENG
S46-p	VKVNGDAsPAAAEPG
K55	AAAEPGAKEELQANG
S63-p	EELQANGsAPAADKE
K69	GsAPAADKEEPASGS
-	gap
T79	PASGSAATPAAAEKD
K85	ATPAAAEKDEAAAAT
G97	AATEPGAGAADKEAA
K101	PGAGAADKEAAEAEP
S112-p	EAEPAEPssPAAEAE
S113-p	AEPAEPssPAAEAEG
-	gap
S122-p	AAEAEGAsAsstssP
S124-p	EAEGAsAsstssPKA
S125-p	AEGAsAsstssPKAE
T126-p	EGAsAsstssPKAED
S127-p	GAsAsstssPKAEDG
S128-p	AsAsstssPKAEDGA
A136	PKAEDGAAPsPssEt
S138-p	AEDGAAPsPssEtPk
S140-p	DGAAPsPssEtPkkK
S141-p	GAAPsPssEtPkkKK
T143-p	APsPssEtPkkKKKR
K145-u	sPssEtPkkKKKRFs
K146-u	PssEtPkkKKKRFsF
S152-p	kkKKKRFsFKKsFkL
S156-p	KRFsFKKsFkLsGFs
K158-u	FsFKKsFkLsGFsFK
S160-p	FKKsFkLsGFsFKKs
S163-p	sFkLsGFsFKKsKKE
K165	kLsGFsFKKsKKEsG
S167-p	sGFsFKKsKKEsGEG
K169	FsFKKsKKEsGEGAE
S171-p	FKKsKKEsGEGAEAE
S246-p	EPQAEEQsEAAGEKA
-	gap
S291	ASAAPAASPEPQPEC
S299	PEPQPECSPEAPPAP

	rat
K11	QFSKTAAKGEAAAER
A15	TAAKGEAAAERPGEA
S26	PGEAAVASSPSKANG
S27	GEAAVASSPSKANGQ
S29	AAVASSPSKANGQEN
K30	AVASSPSKANGQENG
S46-p	VKVNGDAsPAAAEPG
K55	AAAEPGAKEELQANG
S63	EELQANGSAPAADKE
K69	GSAPAADKEEPASGG
-	gap
T79	PASGGAATPAAADKD
K85	ATPAAADKDEAAAAP
A97	AAPEPGAATADKEAA
K101	PGAATADKEAAEAEP
G112	EAEPAEPGSPSAETE
S113	AEPAEPGSPSAETEG
S115	PAEPGSPSAETEGAS
S122	SAETEGASASSTSSP
S124	ETEGASASSTSSPKA
S125	TEGASASSTSSPKAE
T126	EGASASSTSSPKAED
S127	GASASSTSSPKAEDG
S128	ASASSTSSPKAEDGA
A136	PKAEDGAAPsPsSEt
S138-p	AEDGAAPsPsSEtPK
S140-p	DGAAPsPsSEtPKKK
S141	GAAPsPsSEtPKKKK
T143-p	APsPsSEtPKKKKKR
K145	sPsSEtPKKKKKRFs
K146	PsSEtPKKKKKRFsF
S152-p	KKKKKRFsFKKsFKL
S156-p	KRFsFKKsFKLSGFs
K158	FsFKKsFKLSGFsFK
S160	FKKsFKLSGFsFKKS
S163-p	sFKLSGFsFKKSKKE
K165	KLSGFsFKKSKKEAG
S167	SGFsFKKSKKEAGEG
K169	FsFKKSKKEAGEGAE
A171	FKKSKKEAGEGAEAE
S246	EPRAEEPSEAVGEKA
-	gap
S291-p	ASAAPSAsPEPQPEC
S299-p	PEPQPECsPEAPPAP

	chicken
K11	QFSKTAAKGEAAAEK
A15	TAAKGEAAAEKPGEA
A25	KPGEAVAAsPSKANG
S26-p	PGEAVAAsPSKANGQ
S28	EAVAAsPSKANGQEN
K29	AVAAsPSKANGQENG
S45	VKVNGDASPAAAEAG
K53	PAAAEAGKEEVQANG
S61	EEVQANGSAPAEETG
T67	GSAPAEETGKEEAAS
-	gap
-	gap
K69	APAEETGKEEAASSE
-	gap
K81	SSEPASEKEAAEAES
A92	EAESTEPASPAEGEA
S93	AESTEPASPAEGEAS
-	gap
-	gap
E96	TEPASPAEGEASPKT
G97	EPASPAEGEASPKTE
E98	PASPAEGEASPKTEE
A99	ASPAEGEASPKTEEG
S100	SPAEGEASPKTEEGA
T108	PKTEEGATPSSSSET
S110	TEEGATPSSSSETPK
S112	EGATPSSSSETPKKK
S113	GATPSSSSETPKKKK
T115	TPSSSSETPKKKKKR
K117	SSSSETPKKKKKRFs
K118	SSSETPKKKKKRFsF
S124-p	KKKKKRFsFKKsFKL
S128-p	KRFsFKKsFKLsGFs
K130	FsFKKsFKLsGFsFK
S132-p	FKKsFKLsGFsFKKN
S135-p	sFKLsGFsFKKNKKE
K137	KLsGFsFKKNKKEAG
N139	sGFsFKKNKKEAGEG
K141	FsFKKNKKEAGEGAE
A143	FKKNKKEAGEGAESE
-	gap
-	gap
-	gap
S272	QEAPSESSPEGPAEP

	cow
K11	QFSKTAAKGEATAER
T15	TAAKGEATAERPGEA
S26	PGEAAVASSPSKANG
S27	GEAAVASSPSKANGQ
S29	AAVASSPSKANGQEN
K30	AVASSPSKANGQENG
S46	VKVNGDASPAAAEPG
K55	AAAEPGAKEELQANG
S63	EELQANGSAPAADKE
K69	GSAPAADKEEPAAAG
S77	EEPAAAGSGAASPAA
S81	AAGSGAASPAAAEKD
K87	ASPAAAEKDEPAAAA
S100	AAPDAGASPVEKEAP
K104	AGASPVEKEAPVEGE
G116	EGEAAEPGSPTAAEG
S117	GEAAEPGSPTAAEGE
T119	AAEPGSPTAAEGEAA
S127	AAEGEAASAASSTSS
S130	GEAASAASSTSSPKA
S131	EAASAASSTSSPKAE
T132	AASAASSTSSPKAED
S133	ASAASSTSSPKAEDG
S134	SAASSTSSPKAEDGA
T142	PKAEDGATPSPSNET
S144	AEDGATPSPSNETPK
S146	DGATPSPSNETPKKK
N147	GATPSPSNETPKKKK
T149	TPSPSNETPKKKKKR
K151	SPSNETPKKKKKRFs
K152	PSNETPKKKKKRFsF
S158-p	KKKKKRFsFKKsFKL
S162-p	KRFsFKKsFKLsGFs
K164	FsFKKsFKLsGFsFK
S166-p	FKKsFKLsGFsFKKN
S169-p	sFKLsGFsFKKNKKE
K171	KLsGFsFKKNKKEAG
N173	sGFsFKKNKKEAGEG
K175	FsFKKNKKEAGEGGE
A177	FKKNKKEAGEGGEAE
S264	AKAVEEPSKAEEKAE
-	gap
S315	SSACAAPSQEAQPEC
S323	QEAQPECSPEAPPAE

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