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Protein Page:
MARCKS (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MARCKS the most prominent cellular substrate of protein kinase C. Binds calmodulin, actin, and synapsin. A filamentous actin cross-linking protein. Critical for normal brain development. Phosphorylation by PKC displaces it from the plasma membrane, inhibiting F-actin cross-linking activity. Plays a role in growth cone adhesion: its nonphosphorylated form stabilizes integrin-mediated adhesions, and its phosphorylation-triggered release from adhesions causes localized growth cone detachment. Highly expressed in immature T and B lymphocytes: its expression is highest in CD4-8- T cells and B-cell blasts generated by antigen receptor signaling. Its expression and phosphorylation are closely linked to microglial activation processes involved in pathological conditions such as neuroinflammation and neurodegeneration. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Chromosomal Location of Human Ortholog: 6q22.2
Cellular Component: germinal vesicle; centrosome; plasma membrane; cell cortex; actin cytoskeleton
Molecular Function: actin filament binding; calmodulin binding; protein kinase C binding
Biological Process: energy reserve metabolic process; regulation of insulin secretion
Reference #:  P29966 (UniProtKB)
Alt. Names/Synonyms: 80K-L; 80K-L protein; FLJ14368; FLJ90045; MACS; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; PKCSL; PRKCSL; Protein kinase C substrate, 80 kDa protein, light chain
Gene Symbols: MARCKS
Molecular weight: 31,555 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MARCKS

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 25 K11-ub QFSKTAAkGEAAAER
0 1 A15 TAAkGEAAAERPGEA
1 12 S26-p PGEAAVAssPskANG
6 36 S27-p GEAAVAssPskANGQ
0 19 S29-p AAVAssPskANGQEN
0 2 K30-ub AVAssPskANGQENG
0 23 S46-p VKVNGDAsPAAAESG
0 1 K55-ub AAAESGAkEELQANG
0 5 S63-p EELQANGsAPAADkE
0 1 K69-ub GsAPAADkEEPAAAG
0 8 S77-p EEPAAAGsGAAsPsA
0 12 S81-p AAGsGAAsPsAAEkG
0 1 S83-p GsGAAsPsAAEkGEP
0 1 K87-ub AsPsAAEkGEPAAAA
0 21 S101-p AAPEAGAsPVEkEAP
0 1 K105-ub AGAsPVEkEAPAEGE
0 4 G117 EGEAAEPGsPtAAEG
1 19 S118-p GEAAEPGsPtAAEGE
0 6 T120-p AAEPGsPtAAEGEAA
0 5 S128-p AAEGEAAsAAsstss
1 6 S131-p GEAAsAAsstssPKA
1 4 S132-p EAAsAAsstssPKAE
1 3 T133-p AAsAAsstssPKAED
1 4 S134-p AsAAsstssPKAEDG
1 7 S135-p sAAsstssPKAEDGA
0 8 T143-p PKAEDGAtPsPsNEt
0 30 S145-p AEDGAtPsPsNEtPk
1 21 S147-p DGAtPsPsNEtPkkK
0 5 N148 GAtPsPsNEtPkkKK
1 47 T150-p tPsPsNEtPkkKKKR
0 2 K152-ub sPsNEtPkkKKKRFs
0 2 K153-ub PsNEtPkkKKKRFsF
22 18 S159-p kkKKKRFsFKKsFkL
20 22 S163-p KRFsFKKsFkLsGFs
0 3 K165-ub FsFKKsFkLsGFsFk
5 33 S167-p FKKsFkLsGFsFkKN
8 131 S170-p sFkLsGFsFkKNKkE
0 21 K172-ac kLsGFsFkKNKkEAG
0 1 K172-sc kLsGFsFkKNKkEAG
0 1 N174 sGFsFkKNKkEAGEG
0 1 K176-ub FsFkKNKkEAGEGGE
0 4 A178 FkKNKkEAGEGGEAE
0 2 S262-p TKAAEEPsKVEEkKA
0 1 K267-ub EPsKVEEkKAEEAGA
0 2 S314-p SSACAAPsQEAQPEC
0 1 S322 QEAQPECSPEAPPAE
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
  mouse

 
K11-ub QFSKTAAkGEAtAER
T15-p TAAkGEAtAERPGEA
S26-p PGEAAVAssPsKANG
S27-p GEAAVAssPsKANGQ
S29-p AAVAssPsKANGQEN
K30 AVAssPsKANGQENG
S46-p VKVNGDAsPAAAEPG
K55 AAAEPGAKEELQANG
S63-p EELQANGsAPAADKE
K69 GsAPAADKEEPASGS
S76 KEEPASGSAATPAAA
T79 PASGSAATPAAAEKD
- gap
K85 ATPAAAEKDEAAAAT
G97 AATEPGAGAADKEAA
K101 PGAGAADKEAAEAEP
S112-p EAEPAEPssPAAEAE
S113-p AEPAEPssPAAEAEG
- gap
S122-p AAEAEGAsAsstssP
S124-p EAEGAsAsstssPKA
S125-p AEGAsAsstssPKAE
T126-p EGAsAsstssPKAED
S127-p GAsAsstssPKAEDG
S128-p AsAsstssPKAEDGA
A136 PKAEDGAAPsPssEt
S138-p AEDGAAPsPssEtPk
S140-p DGAAPsPssEtPkkK
S141-p GAAPsPssEtPkkKK
T143-p APsPssEtPkkKKKR
K145-ub sPssEtPkkKKKRFs
K146-ub PssEtPkkKKKRFsF
S152-p kkKKKRFsFKKsFkL
S156-p KRFsFKKsFkLsGFs
K158-ub FsFKKsFkLsGFsFK
S160-p FKKsFkLsGFsFKKs
S163-p sFkLsGFsFKKsKKE
K165 kLsGFsFKKsKKEsG
K165 kLsGFsFKKsKKEsG
S167-p sGFsFKKsKKEsGEG
K169 FsFKKsKKEsGEGAE
S171-p FKKsKKEsGEGAEAE
S246-p EPQAEEQsEAAGEKA
- gap
S291 ASAAPAASPEPQPEC
S299 PEPQPECSPEAPPAP
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
  rat

 
K11 QFSKTAAKGEAAAER
A15 TAAKGEAAAERPGEA
S26-p PGEAAVAssPsKANG
S27-p GEAAVAssPsKANGQ
S29-p AAVAssPsKANGQEN
K30 AVAssPsKANGQENG
S46-p VKVNGDAsPAAAEPG
K55 AAAEPGAKEELQANG
S63-p EELQANGsAPAADKE
K69 GsAPAADKEEPASGG
- gap
T79-p PASGGAAtPAAADKD
- gap
K85 AtPAAADKDEAAAAP
A97 AAPEPGAATADKEAA
K101 PGAATADKEAAEAEP
G112 EAEPAEPGsPSAETE
S113-p AEPAEPGsPSAETEG
S115 PAEPGsPSAETEGAs
S122-p SAETEGAsASSTSSP
S124 ETEGAsASSTSSPKA
S125 TEGAsASSTSSPKAE
T126 EGAsASSTSSPKAED
S127 GAsASSTSSPKAEDG
S128 AsASSTSSPKAEDGA
A136 PKAEDGAAPsPsSEt
S138-p AEDGAAPsPsSEtPK
S140-p DGAAPsPsSEtPKKK
S141 GAAPsPsSEtPKKKK
T143-p APsPsSEtPKKKKKR
K145 sPsSEtPKKKKKRFs
K146 PsSEtPKKKKKRFsF
S152-p KKKKKRFsFKKsFKL
S156-p KRFsFKKsFKLsGFs
K158 FsFKKsFKLsGFsFk
S160-p FKKsFKLsGFsFkKS
S163-p sFKLsGFsFkKSKKE
K165-ac KLsGFsFkKSKKEAG
K165 KLsGFsFKKSKKEAG
S167 sGFsFkKSKKEAGEG
K169 FsFkKSKKEAGEGAE
A171 FkKSKKEAGEGAEAE
S246 EPRAEEPSEAVGEKA
- gap
S291-p ASAAPSAsPEPQPEC
S299-p PEPQPECsPEAPPAP
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
2741 : Phospho-MARCKS (Ser152/156) Antibody
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
  chicken

 
K11 QFSKTAAKGEAAAEK
A15 TAAKGEAAAEKPGEA
A25 KPGEAVAAsPSKANG
S26-p PGEAVAAsPSKANGQ
S28 EAVAAsPSKANGQEN
K29 AVAAsPSKANGQENG
S45 VKVNGDASPAAAEAG
K53 PAAAEAGKEEVQANG
S61 EEVQANGSAPAEETG
T67 GSAPAEETGKEEAAS
- gap
- gap
- gap
K69 APAEETGKEEAASSE
- gap
K81 SSEPASEKEAAEAES
A92 EAESTEPASPAEGEA
S93 AESTEPASPAEGEAS
- gap
- gap
E96 TEPASPAEGEASPKT
G97 EPASPAEGEASPKTE
E98 PASPAEGEASPKTEE
A99 ASPAEGEASPKTEEG
S100 SPAEGEASPKTEEGA
T108 PKTEEGATPSSSSET
S110 TEEGATPSSSSETPK
S112 EGATPSSSSETPKKK
S113 GATPSSSSETPKKKK
T115 TPSSSSETPKKKKKR
K117 SSSSETPKKKKKRFs
K118 SSSETPKKKKKRFsF
S124-p KKKKKRFsFKKsFKL
S128-p KRFsFKKsFKLsGFs
K130 FsFKKsFKLsGFsFK
S132-p FKKsFKLsGFsFKKN
S135-p sFKLsGFsFKKNKKE
K137 KLsGFsFKKNKKEAG
K137 KLsGFsFKKNKKEAG
N139 sGFsFKKNKKEAGEG
K141 FsFKKNKKEAGEGAE
A143 FKKNKKEAGEGAESE
- gap
- gap
- gap
S272 QEAPSESSPEGPAEP
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
  cow

 
K11 QFSKTAAKGEATAER
T15 TAAKGEATAERPGEA
S26 PGEAAVASSPSKANG
S27 GEAAVASSPSKANGQ
S29 AAVASSPSKANGQEN
K30 AVASSPSKANGQENG
S46 VKVNGDASPAAAEPG
K55 AAAEPGAKEELQANG
S63 EELQANGSAPAADKE
K69 GSAPAADKEEPAAAG
S77 EEPAAAGSGAASPAA
S81 AAGSGAASPAAAEKD
- gap
K87 ASPAAAEKDEPAAAA
S100 AAPDAGASPVEKEAP
K104 AGASPVEKEAPVEGE
G116 EGEAAEPGSPTAAEG
S117 GEAAEPGSPTAAEGE
T119 AAEPGSPTAAEGEAA
S127 AAEGEAASAASSTSS
S130 GEAASAASSTSSPKA
S131 EAASAASSTSSPKAE
T132 AASAASSTSSPKAED
S133 ASAASSTSSPKAEDG
S134 SAASSTSSPKAEDGA
T142 PKAEDGATPSPSNET
S144 AEDGATPSPSNETPK
S146 DGATPSPSNETPKKK
N147 GATPSPSNETPKKKK
T149 TPSPSNETPKKKKKR
K151 SPSNETPKKKKKRFs
K152 PSNETPKKKKKRFsF
S158-p KKKKKRFsFKKsFKL
S162-p KRFsFKKsFKLsGFs
K164 FsFKKsFKLsGFsFK
S166-p FKKsFKLsGFsFKKN
S169-p sFKLsGFsFKKNKKE
K171 KLsGFsFKKNKKEAG
K171 KLsGFsFKKNKKEAG
N173 sGFsFKKNKKEAGEG
K175 FsFKKNKKEAGEGGE
A177 FKKNKKEAGEGGEAE
S264 AKAVEEPSKAEEKAE
- gap
S315 SSACAAPSQEAQPEC
S323 QEAQPECSPEAPPAE
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
11992 : Phospho-MARCKS (Ser159/163) (D13D2) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
8722 : Phospho-MARCKS (Ser167/170) (D13E4) XP(R) Rabbit mAb
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