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Protein Page:
MALT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MALT1 Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. Belongs to the peptidase C14B family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ligase; Adaptor/scaffold; Apoptosis; Protease; Nuclear export; EC 3.4.22.-; Ubiquitin conjugating system
Cellular Component: CBM complex; protein complex; perinuclear region of cytoplasm; cytoplasm; nucleolus; plasma membrane; nucleus; cytosol
Molecular Function: peptidase activity; protein binding; signal transducer activity; protease binding; protein self-association; cysteine-type endopeptidase activity; kinase activator activity; ubiquitin-protein ligase activity
Biological Process: response to fungus; positive regulation of I-kappaB kinase/NF-kappaB cascade; activation of NF-kappaB-inducing kinase; nuclear export; protein ubiquitination; positive regulation of T cell cytokine production; defense response; proteolysis; T cell receptor signaling pathway; protein oligomerization; activation of NF-kappaB transcription factor; T cell proliferation; regulation of apoptosis; B-1 B cell differentiation; positive regulation of protein ubiquitination; response to molecule of bacterial origin; regulation of T cell receptor signaling pathway; positive regulation of interleukin-2 production; innate immune response; positive regulation of T cell activation; negative regulation of apoptosis
Reference #:  Q9UDY8 (UniProtKB)
Alt. Names/Synonyms: caspase-like protein; DKFZp434L132; MALT associated translocation; MALT lymphoma-associated translocation; MALT-lymphoma associated translocation; MALT1; MLT; MLT1; mucosa associated lymphoid tissue lymphoma translocation gene 1; Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Paracaspase
Gene Symbols: MALT1
Molecular weight: 92,272 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MALT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S2-p ______MsLLGDPLQ
0 2 L11 LGDPLQALPPSAAPt
0 1 T18-p LPPSAAPtGPLLAPP
0 3 T29-p LAPPAGAtLNRLREP
0 2 S70-p SRGRLRLsCLDLEQC
0 5 S135-p KITVNPEsKAVLAGQ
0 1 T387-p VVSLLDLtEYEMRNA
2 0 K644-ub LDLDIDPkDANkGTP
1 1 K648-ub IDPkDANkGTPEETG
1 0 K661-ub TGSYLVSkDLPkHCL
1 0 K665-ub LVSkDLPkHCLYTRL
0 1 S674-p CLYTRLSsLQkLkEH
1 0 K677-ub TRLSsLQkLkEHLVF
1 0 K679-ub LSsLQkLkEHLVFTV
1 0 K702-ub LEDTVEDkQEVNVGk
1 0 K709-ub kQEVNVGkPLIAkLD
1 0 K714-ub VGkPLIAkLDMHRGL
1 0 K724-ub MHRGLGRkTCFQTCL
1 0 K824-ub DRLRISEk_______
  mouse

 
S2 ______MSLWGQPLQ
S11-p WGQPLQAsPPLAVRQ
S24 RQPPTASSGPSTSPP
T35 TSPPAGATLNRLPEP
S76 SRGRLRLSGLDLEQC
S141-p KITVNPEsKAVLAGQ
T395 VVSLLDLTEYEMCNA
K652 LDLDIDPKHANKGTP
K656 IDPKHANKGTPEETG
K669 TGSYLVSKDLPKHCL
K673 LVSKDLPKHCLYTRL
S682 CLYTRLSSLQKLKEH
K685 TRLSSLQKLKEHLIF
K687 LSSLQKLKEHLIFTV
K710 LEDTVEEKQEVNVGK
K717 KQEVNVGKPLIAKLD
K722 VGKPLIAKLDMHRGL
K732 MHRGLGRKTCFQACR
N832 DRLMISEN_______
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