Home

LAT (human)

Overview LAT an adaptor protein involved in T-cell antigen receptor (TCR) signal transduction pathway. Plays an important role downstream of protein tyrosine kinases. Essential for TCR-mediated Ras-Erk activation and calcium flux. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Adaptor/scaffold Cellular Component: signalosome; integral to membrane; plasma membrane; immunological synapse; lipid raft Molecular Function: protein binding; SH3/SH2 adaptor activity; protein kinase binding Biological Process: integrin-mediated signaling pathway; platelet activation; T cell activation; Ras protein signal transduction; calcium-mediated signaling; immune response; mast cell degranulation; blood coagulation; T cell receptor signaling pathway; regulation of T cell activation Reference #:  O43561 (UniProtKB) Alt. Names/Synonyms: 36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; LAT; LAT1; linker for activation of T cells; Linker for activation of T-cells family member 1; p36-38; pp36 Gene Symbols: LAT Molecular weight: 27,930 Da Basal Isoelectric point: 4.27  Predict pI for various phosphorylation states CST Pathways:  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below LAT

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cytoskeletal reorganization: Y200‑p, Y220‑p transcription, altered: Y200‑p, Y220‑p, Y255‑p activation: Y200‑p, Y220‑p, Y255‑p molecular association, regulation: Y161‑p, Y200‑p, Y220‑p, Y255‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		S35-p	HCHRLPGsyDstssD
0	3		Y36-p	CHRLPGsyDstssDs
0	1		S38-p	RLPGsyDstssDsLy
0	3		T39-p	LPGsyDstssDsLyP
0	4		S40-p	PGsyDstssDsLyPR
0	5		S41-p	GsyDstssDsLyPRG
0	14		S43-p	yDstssDsLyPRGIQ
0	71		Y45-p	stssDsLyPRGIQFK
0	2		T68-p	PPAYPPVtSyPPLsQ
0	2		Y70-p	AYPPVtSyPPLsQPD
0	5		S74-p	VtSyPPLsQPDLLPI
0	19		S84-p	DLLPIPRsPQPLGGs
0	11		S91-p	sPQPLGGsHRtPssR
0	1		T94-p	PLGGsHRtPssRRDs
0	2		S96-p	GGsHRtPssRRDsDG
0	4		S97-p	GsHRtPssRRDsDGA
0	7		S101-p	tPssRRDsDGANsVA
0	5		S106-p	RDsDGANsVAsyENE
0	5		S109-p	DGANsVAsyENEGAS
1	2		Y110-p	GANsVAsyENEGASG
2	1		Y156-p	ADEDEDDyHNPGyLV
14	1		Y161-p	DDyHNPGyLVVLPDS
0	1		S183-p	APSAPALstPGIRDS
1	11		T184-p	PSAPALstPGIRDSA
15	17		Y200-p	SMESIDDyVNVPEsG
0	4		S206-p	DyVNVPEsGESAEAs
0	5		S213-p	sGESAEAsLDGsREy
0	2		S217-p	AEAsLDGsREyVNVs
23	40		Y220-p	sLDGsREyVNVsQEL
0	22		S224-p	sREyVNVsQELHPGA
0	1		A238	AAKTEPAALssQEAE
0	1		S240-p	KTEPAALssQEAEEV
0	2		S241-p	TEPAALssQEAEEVE
11	78		Y255-p	EEEGAPDyENLQELN

	LAT iso2
S35	HCHRLPGSYDSTSSD
Y36	CHRLPGSYDSTSSDS
S38	RLPGSYDSTSSDSLy
T39	LPGSYDSTSSDSLyP
S40	PGSYDSTSSDSLyPR
S41	GSYDSTSSDSLyPRG
S43	YDSTSSDSLyPRGIQ
Y45-p	STSSDSLyPRGIQFK
T68	PPAYPPVTSYPPLSQ
Y70	AYPPVTSYPPLSQPD
S74	VTSYPPLSQPDLLPI
S84	DLLPIPRSPQPLGGS
S91	SPQPLGGSHRTPSSR
T94	PLGGSHRTPSSRRDS
S96	GGSHRTPSSRRDSDG
S97	GSHRTPSSRRDSDGA
S101	TPSSRRDSDGANSVA
S106	RDSDGANSVASyENE
S109	DGANSVASyENEEPA
Y110-p	GANSVASyENEEPAC
Y127-p	ADEDEDDyHNPGyLV
Y132-p	DDyHNPGyLVVLPDS
S154	APSAPALStPGIRDS
T155-p	PSAPALStPGIRDSA
Y171-p	SMESIDDyVNVPESG
S177	DyVNVPESGESAEAS
S184	SGESAEASLDGSREy
S188	AEASLDGSREyVNVS
Y191-p	SLDGSREyVNVSQEL
S195	SREyVNVSQELHPGA
A209	AAKTEPAALSSQEAE
S211	KTEPAALSSQEAEEV
S212	TEPAALSSQEAEEVE
Y226-p	EEEGAPDyENLQELN

	mouse
S36	RCRELPVSyDststE
Y37-p	CRELPVSyDststEs
S39-p	ELPVSyDststEsLY
T40-p	LPVSyDststEsLYP
S41-p	PVSyDststEsLYPR
T42-p	VSyDststEsLYPRS
S44-p	yDststEsLYPRSIL
Y46	ststEsLYPRSILIK
T71	AVSYPLVTSFPPLRQ
F73	SYPLVTSFPPLRQPD
R77	VTSFPPLRQPDLLPI
S87-p	DLLPIPRsPQPLGGs
S94-p	sPQPLGGsHRMPSSQ
M97	PLGGsHRMPSSQQNS
S99	GGsHRMPSSQQNSDD
S100	GsHRMPSSQQNSDDA
S104	MPSSQQNSDDANsVA
S109-p	QNSDDANsVAsyENQ
S112-p	DDANsVAsyENQEPA
Y113-p	DANsVAsyENQEPAC
Y132	ADEDEDDYPNGyLVV
Y136-p	EDDYPNGyLVVLPDS
S158	VSSAPVPSNPDLGDS
N159	SSAPVPSNPDLGDSA
Y175-p	SVESCEDyVNVPESE
S181	DyVNVPESEESAEAS
S188	SEESAEASLDGSREy
S192	AEASLDGSREyVNVs
Y195-p	SLDGSREyVNVsPEQ
S199-p	SREyVNVsPEQQPVT
S212-p	VTRAELAsVNsQEVE
N214	RAELAsVNsQEVEDE
S215-p	AELAsVNsQEVEDEG
Y235-p	DGEEAPDyENLQELN

	rat
S36	RCRELPASYDSASTE
Y37	CRELPASYDSASTES
S39	ELPASYDSASTESLY
A40	LPASYDSASTESLYP
S41	PASYDSASTESLYPR
T42	ASYDSASTESLYPRS
S44	YDSASTESLYPRSIL
Y46	SASTESLYPRSILIK
T71	ATSYPLVTSFPPLRQ
F73	SYPLVTSFPPLRQPD
R77	VTSFPPLRQPDLLPI
S87	DLLPIPRSPQPLGGS
S94	SPQPLGGSHRMPSSR
M97	PLGGSHRMPSSRQNS
S99	GGSHRMPSSRQNSDD
S100	GSHRMPSSRQNSDDA
S104	MPSSRQNSDDANSVA
S109	QNSDDANSVASYENQ
S112	DDANSVASYENQEPA
Y113	DANSVASYENQEPAR
Y132	EDEDEDDYPEGYLVV
Y136	EDDYPEGYLVVLPDS
S158	VSSAPVPSNPDLGDS
N159	SSAPVPSNPDLGDSA
Y175	SMESCEDYVNVPESE
S181	DYVNVPESEESAEAS
S188	SEESAEASLDGSREY
S192	AEASLDGSREYVNVS
Y195	SLDGSREYVNVSQDA
S199	SREYVNVSQDAQPVI
S212	VIRAELASVTSQEVE
T214	RAELASVTSQEVEDE
S215	AELASVTSQEVEDEE
Y234-p	DGEEAPDyENLQELN

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.