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Protein Page:
TAX1BP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TAX1BP1 Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLV-1 protein Tax-1. Expressed in all tissues tested. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Cellular Component: cytosol
Molecular Function: protein binding; kinase binding
Biological Process: apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interferon type I production; negative regulation of apoptosis
Reference #:  Q86VP1 (UniProtKB)
Alt. Names/Synonyms: CALCOCO3; T6BP; Tax1 (human T-cell leukemia virus type I) binding protein 1; Tax1-binding protein 1; TAX1BP1; TAXB1; TRAF6-binding protein; TXBP151
Gene Symbols: TAX1BP1
Molecular weight: 90,877 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TAX1BP1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S123-p TPFQFRAssPVEELL
0 4 S124-p PFQFRAssPVEELLT
0 1 S138 TMEDEGNSDMLVVTT
0 1 T157-gl LELKIEKtMKEKEEL
0 1 K173 KLIAVLEKETAQLRE
0 5 K204-u DQLQAEQkGLtEVTQ
0 2 T207-p QAEQkGLtEVTQSLK
0 1 S212 GLtEVTQSLKMENEE
0 1 S225-p EEFKKRFsDATSKAH
0 1 K244 DIVSVTHKAIEKETE
0 1 S254-p EKETELDsLKDKLKK
0 1 K288 ELYKVHLKNTEIENT
0 1 K305 MSEVQTLKNLDGNKE
0 1 G323 THFKEEIGRLQLCLA
0 1 S378-p VFLAKELsDAVNVRD
0 1 K465-u RLQKQINkLSDQSAN
0 1 S491 QQKVNDASVNTDPAT
0 1 K534-u MTKEIADkTEkYNkC
0 1 K537-u EIADkTEkYNkCKQL
0 1 K540-u DkTEkYNkCKQLLQD
0 5 K561-u KYADELAkMELKWKE
0 1 K571-u LKWKEQVkIAENVKL
0 2 Y587-p LAEVQDNykELKRsL
0 1 - gap
0 1 - gap
0 1 K588-u AEVQDNykELKRsLE
0 1 R592 DNykELKRsLENPAE
1 2 S593-p NykELKRsLENPAER
0 5 K601 LENPAERKMEGQNSQ
0 4 N606 ERKMEGQNSQSPQCF
1 115 S666-p RPPVRVPsWGLEDNV
0 2 S683-p SQPARNFsRPDGLED
0 2 K695-u LEDSEDSkEDENVPT
  TAX1BP1 iso2  
S123 TPFQFRASSPVEELL
S124 PFQFRASSPVEELLT
S138 TMEDEGNSDMLVVTT
T157 LELKIEKTMKEKEEL
K173 KLIAVLEKETAQLRE
K204 DQLQAEQKGLTEVTQ
T207 QAEQKGLTEVTQSLK
S212 GLTEVTQSLKMENEE
S225 EEFKKRFSDATSKAH
K244 DIVSVTHKAIEKETE
S254 EKETELDSLKDKLKK
K288 ELYKVHLKNTEIENT
K305 MSEVQTLKNLDGNKE
G323 THFKEEIGRLQLCLA
S378 VFLAKELSDAVNVRD
K465 RLQKQINKLSDQSAN
S491 QQKVNDASVNTDPAT
K534 MTKEIADKTEKYNKC
K537 EIADKTEKYNKCKQL
K540 DKTEKYNKCKQLLQD
K561 KYADELAKMELKWKE
K571 LKWKEQVKIAENVKL
Y587 LAEVQDNYKELKRsL
- gap
- gap
K588 AEVQDNYKELKRsLE
R592 DNYKELKRsLENPAE
S593-p NYKELKRsLENPAER
K601-u LENPAERkMEDGADG
- gap
S624-p RPPVRVPsWGLEDNV
S641 SQPARNFSRPDGLED
K653 LEDSEDSKEDENVPT
  mouse

 
A123 TPFQFRAAsPVEELL
S124-p PFQFRAAsPVEELLT
S138-p TMEDEGNsDMLVVTT
T157 LELKIEKTLKEKEEL
K173-u KLIAVLEkETAQLRE
K204 EQLQAEQKGLLEVSQ
L207 QAEQKGLLEVSQsLR
S212-p GLLEVSQsLRVENEE
S225 EEFMKRYSDATAKVQ
K244-u DIVSVTHkAIEKETD
S254-p EKETDLDsLKDKLRK
K288-u ELYKVHLkNTEIENT
K305-u VSEIQTLkNLDGNKE
S323-p THFKEEIsKLQSCLA
S378 IFLTKELSDAVNVRD
K465 RLQKQINKLSDQAAS
S491-p QQKVNDAsINTDPAA
K536 MTKEIAEKIEKYNKC
K539 EIAEKIEKYNKCKQL
K542 EKIEKYNKCKQLLQD
K563-u KYAEELAkMELKWKE
K573 LKWKEQVKIAENVKL
Y589 LAEVEDNYKVQLAEK
K598-u VQLAEKEkEINGLAs
S605-p kEINGLAsYLENLSR
K614 LENLSREKELTksLE
K618-u SREKELTksLEDQKG
S619-p REKELTksLEDQKGR
K627-u LEDQKGRkLEGQsPQ
S632-p GRkLEGQsPQQVSRC
S693-p RPPVRVPsWEDNVVC
S708-p SQPARNLsRPDGLED
R720 LEDPEDSREDENVPI
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