Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
TANK (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TANK Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Adaptor/scaffold
Cellular Component: cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding; metal ion binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; innate immune response; signal transduction
Reference #:  Q92844 (UniProtKB)
Alt. Names/Synonyms: I-TRAF; ITRAF; TANK; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein; TRAF2
Gene Symbols: TANK
Molecular weight: 47,816 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TANK

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 N72 VNSTQDNNyGCVPLL
0 8 Y73-p NSTQDNNyGCVPLLE
0 2 K86-u LEDSETRkNNLTLDQ
0 2 S117-p VRRQEVSsPRKETSA
0 2 S126-p RKETSARsLGsPLLH
0 6 S129-p TSARsLGsPLLHERG
0 4 K189-u QCTDKTDkQEALFkP
0 14 K195-u DkQEALFkPQAkDDI
0 8 K199-u ALFkPQAkDDINRGA
0 2 S208-p DINRGAPsITSVtPR
0 18 T213-p APsITSVtPRGLCRD
0 8 S225-p CRDEEDTsFEsLskF
0 5 S228-p EEDTsFEsLskFNVK
0 1 S230-p DTsFEsLskFNVKFP
0 7 K231-u TsFEsLskFNVKFPP
0 2 S243-p FPPMDNDsTFLHStP
0 4 T249-p DsTFLHStPERPGIL
0 4 S257-p PERPGILsPATsEAV
0 3 S261-p GILsPATsEAVCQEK
0 4 K282-u DNPGNFVkTEETLFE
0 11 K304-u ASAIQNLkTTDKTKP
0 3 Y338-p PGDHNALyVNsFPLL
0 1 S341-p HNALyVNsFPLLDPS
0 4 S354-p PSDAPFPsLDsPGKA
0 3 S357-p APFPsLDsPGKAIRG
0 2 K371-u GPQQPIWkPFPNQDS
0 1 S380-p FPNQDSDsVVLSGTD
  mouse

 
S107-p VDSSRDNsYGYVPLL
Y108 DSSRDNsYGYVPLLE
K121 LEDSDRRKNNLTLDE
S152 VRRQEVSSGKESAKG
G159 SGKESAKGLNIPLHH
I162 ESAKGLNIPLHHERD
K222 QCTDKTEKQEALFKP
K228 EKQEALFKPQAkDDI
K232-u ALFKPQAkDDINRGM
C241 DINRGMSCVTAVTPR
T246 MSCVTAVTPRGLGRD
S258-p GRDEEDTsFEsLSKF
S261-p EEDTsFEsLSKFNVK
S263 DTsFEsLSKFNVKFP
K264 TsFEsLSKFNVKFPP
S276 FPPMDNDSIFLHSTP
T282 DSIFLHSTPEAPSIL
A290 PEAPSILAPATPETV
P294 SILAPATPETVCQDR
K315 DNPGNFVKTEETLFE
K337 TSAIQNLKTTDKTNP
Y361 AGDHNVFYVNTFPLQ
T364 HNVFYVNTFPLQDPP
S377 PPDAPFPSLDsPGKA
S380-p APFPSLDsPGKAVRG
K394 GPQQPFWKPFLNQDT
L403 FLNQDTDLVVPSDSD
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.