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Protein Page:
ITGB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ITGB3 integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: platelet alpha granule membrane; focal adhesion; integral to plasma membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex
Molecular Function: identical protein binding; protein binding; vascular endothelial growth factor receptor 2 binding; protein disulfide isomerase activity; platelet-derived growth factor receptor binding; cell adhesion molecule binding; receptor activity
Biological Process: integrin-mediated signaling pathway; negative regulation of lipid transport; platelet activation; axon guidance; extracellular matrix organization and biogenesis; regulation of bone resorption; viral reproduction; protein folding; negative regulation of lipoprotein metabolic process; wound healing; cell-matrix adhesion; smooth muscle cell migration; angiogenesis involved in wound healing; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; cell-substrate junction assembly; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; cell adhesion; tube development; blood coagulation; leukocyte migration
Reference #:  P05106 (UniProtKB)
Alt. Names/Synonyms: CD61; GP3A; GPIIIa; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Symbols: ITGB3
Molecular weight: 87,058 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGB3

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell adhesion, altered: Y773‑p, S778‑p, Y785‑p
cell motility, altered: Y773‑p, S778‑p
cytoskeletal reorganization: Y773‑p, Y785‑p
activity, induced: Y773‑p
activity, inhibited: Y773‑p, S778‑p, Y785‑p
molecular association, regulation: Y773‑p, S778‑p, Y785‑p
protein conformation: S778‑p
protein processing: Y773‑p, Y785‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T767 RARAKWDTANNPLyK
19 108 Y773-p DTANNPLyKEAtstF
1 0 T777-p NPLyKEAtstFTNIt
1 0 S778-gl PLyKEAtstFTNIty
3 0 S778-p PLyKEAtstFTNIty
2 2 T779-p LyKEAtstFTNItyR
1 0 T784-gl tstFTNItyRGT___
1 1 T784-p tstFTNItyRGT___
17 8 Y785-p stFTNItyRGT____
  mouse

 
T766-p RARAKWDtANNPLyK
Y772-p DtANNPLyKEATStF
T776 NPLyKEATStFTNIT
S777 PLyKEATStFTNITy
S777 PLyKEATStFTNITy
T778-p LyKEATStFTNITyR
T783 TStFTNITyRGT___
T783 TStFTNITyRGT___
Y784-p StFTNITyRGT____
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