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Protein Page:
ITGB3 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

ITGB3 integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Cellular Component: platelet alpha granule membrane; focal adhesion; integral to plasma membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex
Molecular Function: identical protein binding; protein binding; vascular endothelial growth factor receptor 2 binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; cell adhesion molecule binding; receptor activity
Biological Process: negative regulation of lipid transport; integrin-mediated signaling pathway; axon guidance; platelet activation; extracellular matrix organization and biogenesis; regulation of bone resorption; protein folding; wound healing; negative regulation of lipoprotein metabolic process; viral reproduction; cell-matrix adhesion; smooth muscle cell migration; angiogenesis involved in wound healing; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; negative regulation of low-density lipoprotein receptor biosynthetic process; cell-substrate junction assembly; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; tube development; cell adhesion; blood coagulation; leukocyte migration
Reference #:  P05106 (UniProtKB)
Alt. Names/Synonyms: CD61; GP3A; GPIIIa; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Symbols: ITGB3
Molecular weight: 87,058 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Sites Implicated In
cell adhesion, altered: Y773‑p, S778‑p, Y785‑p
cell motility, altered: Y773‑p, S778‑p
cytoskeletal reorganization: Y773‑p, Y785‑p
activity, induced: Y773‑p
activity, inhibited: Y773‑p, S778‑p, Y785‑p
molecular association, regulation: Y773‑p, S778‑p, Y785‑p
protein conformation: S778‑p
protein processing: Y773‑p, Y785‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment


SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


19 108 Y773-p DTANNPLyKEAtstF
1 0 T777-p NPLyKEAtstFTNIt
1 0 S778-gl PLyKEAtstFTNIty
3 0 S778-p PLyKEAtstFTNIty
2 2 T779-p LyKEAtstFTNItyR
1 0 T784-gl tstFTNItyRGT___
1 1 T784-p tstFTNItyRGT___
17 8 Y785-p stFTNItyRGT____

Y784-p StFTNITyRGT____
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