integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Cellular Component: platelet alpha granule membrane; focal adhesion; integral to plasma membrane; melanosome; plasma membrane; nucleus; integrin complex; receptor complex
Molecular Function: identical protein binding; protein binding; vascular endothelial growth factor receptor 2 binding; protein disulfide isomerase activity; platelet-derived growth factor receptor binding; cell adhesion molecule binding; receptor activity
Biological Process: integrin-mediated signaling pathway; negative regulation of lipid transport; platelet activation; axon guidance; extracellular matrix organization and biogenesis; regulation of bone resorption; viral reproduction; protein folding; negative regulation of lipoprotein metabolic process; wound healing; cell-matrix adhesion; smooth muscle cell migration; angiogenesis involved in wound healing; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; cell-substrate junction assembly; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; cell adhesion; tube development; blood coagulation; leukocyte migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.