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Protein Page:
ITGB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ITGB3 integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: platelet alpha granule membrane; focal adhesion; integral to plasma membrane; melanosome; plasma membrane; integrin complex; nucleus; receptor complex
Molecular Function: identical protein binding; protein binding; vascular endothelial growth factor receptor 2 binding; platelet-derived growth factor receptor binding; protein disulfide isomerase activity; receptor activity; cell adhesion molecule binding
Biological Process: negative regulation of lipid transport; integrin-mediated signaling pathway; platelet activation; axon guidance; extracellular matrix organization and biogenesis; regulation of bone resorption; wound healing; negative regulation of lipoprotein metabolic process; protein folding; viral reproduction; cell-matrix adhesion; smooth muscle cell migration; angiogenesis involved in wound healing; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; platelet degranulation; negative regulation of low-density lipoprotein receptor biosynthetic process; activation of protein kinase activity; cell-substrate junction assembly; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; blood coagulation; tube development; cell adhesion; leukocyte migration
Reference #:  P05106 (UniProtKB)
Alt. Names/Synonyms: CD61; GP3A; GPIIIa; Integrin beta-3; integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); ITB3; ITGB3; platelet glycoprotein IIIa; Platelet membrane glycoprotein IIIa
Gene Symbols: ITGB3
Molecular weight: 87,058 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGB3

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y773‑p, S778‑p, Y785‑p
cell motility, altered: Y773‑p, S778‑p
cytoskeletal reorganization: Y773‑p, Y785‑p
activity, induced: Y773‑p
activity, inhibited: Y773‑p, S778‑p, Y785‑p
molecular association, regulation: Y773‑p, S778‑p, Y785‑p
protein conformation: S778‑p
protein processing: Y773‑p, Y785‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T208-p NPCYDMKtTCLPMFG
0 1 T227-p LTLTDQVtRFNEEVK
0 1 S439-p CPQEKEKsFtIKPVG
0 1 T441-p QEKEKsFtIKPVGFK
0 1 Y660-p DENTCNRyCRDEIES
0 2 T767 RARAKWDTANNPLyK
19 103 Y773-p DTANNPLyKEAtstF
0 1 K774 TANNPLyKEAtstFT
1 0 T777-p NPLyKEAtstFTNIt
1 0 S778-gl PLyKEAtstFTNIty
3 0 S778-p PLyKEAtstFTNIty
2 2 T779-p LyKEAtstFTNItyR
1 0 T784-gl tstFTNItyRGT___
1 1 T784-p tstFTNItyRGT___
17 8 Y785-p stFTNItyRGT____
  mouse

 
N207 NPCYNMKNACLPMFG
S226 LTLTDQVSRFNEEVK
S438 CPQEKEQSFTIKPVG
T440 QEKEQSFTIKPVGFK
Y659 EENTCSRYCRDDIEQ
T766-p RARAKWDtANNPLyk
Y772-p DtANNPLykEATStF
K773-ub tANNPLykEATStFT
T776 NPLykEATStFTNIT
S777 PLykEATStFTNITy
S777 PLykEATStFTNITy
T778-p LykEATStFTNITyR
T783 TStFTNITyRGT___
T783 TStFTNITyRGT___
Y784-p StFTNITyRGT____
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