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Protein Page:
hnRNP K (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP K a heterogeneous nuclear ribonucleoprotein (hnRNP). One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; Spliceosome; RNA binding protein
Chromosomal Location of Human Ortholog: 9q21.32-q21.33
Cellular Component: nucleoplasm; cell projection; membrane; cytoplasm; nuclear chromatin; nucleolus; podosome; cell junction; nucleus
Molecular Function: protein binding; RNA binding; single-stranded DNA binding
Biological Process: RNA processing; nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; viral reproduction; RNA splicing; positive regulation of low-density lipoprotein receptor biosynthetic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of receptor-mediated endocytosis
Reference #:  P61978 (UniProtKB)
Alt. Names/Synonyms: CSBP; dC-stretch binding protein; FLJ41122; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; HNRNPK; HNRPK; Transformation up-regulated nuclear protein; transformation upregulated nuclear protein; TUNP
Gene Symbols: HNRNPK
Molecular weight: 50,976 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP K

Protein Structure Not Found.


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Sites Implicated In
cell growth, induced: S116‑p, S284‑p, S353‑p
transcription, altered: S216‑p, S353‑p
transcription, induced: S116‑p, S284‑p, S353‑p
transcription, inhibited: S284‑p
translation, altered: Y72‑p, Y225‑p, Y230‑p, Y234‑p, Y236‑p, S284‑p, S353‑p, Y380‑p
activity, induced: S216‑p, S302‑p, S353‑p
intracellular localization: S116‑p, S284‑p, S353‑p
molecular association, regulation: S302‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 T3-p _____MEtEQPEETF
0 1 K21-ac ETNGEFGkrPAEDME
0 1 R22-m1 TNGEFGkrPAEDMEE
0 33 K34-ac MEEEQAFkRsRNtDE
0 10 K34-ub MEEEQAFkRsRNtDE
0 1 K34-sc MEEEQAFkRsRNtDE
0 6 S36-p EEQAFkRsRNtDEMV
0 12 T39-p AFkRsRNtDEMVELr
0 1 R46-m1 tDEMVELrILLQSkN
0 23 K52-ub LrILLQSkNAGAVIG
0 1 K52-sc LrILLQSkNAGAVIG
0 7 K60-ub NAGAVIGkGGKNIKA
0 1 K66 GkGGKNIKALRTDyN
0 1 T70 KNIKALRTDyNAsVs
2 4 Y72-p IKALRTDyNAsVsVP
0 4 S75-p LRTDyNAsVsVPDSS
0 5 S77-p TDyNAsVsVPDSSGP
0 1 S81 AsVsVPDSSGPERIL
0 1 S91 PERILSISADIETIG
0 1 T96 SISADIETIGEILkk
0 4 K102-ub ETIGEILkkIIPTLE
0 2 K103-ub TIGEILkkIIPTLEE
2 39 S116-p EEGLQLPsPtAtsQL
0 11 T118-p GLQLPsPtAtsQLPL
0 7 T120-p QLPsPtAtsQLPLES
0 12 S121-p LPsPtAtsQLPLESd
0 1 S127 tsQLPLESdAVECLN
0 1 D128-ca sQLPLESdAVECLNy
0 13 Y135-p dAVECLNyQHyKGsD
0 32 Y138-p ECLNyQHyKGsDFDC
0 1 S141-p NyQHyKGsDFDCELR
0 6 S154-p LRLLIHQsLAGGIIG
0 89 K163-ub AGGIIGVkGAkIKEL
0 5 K166-ub IIGVkGAkIKELREN
0 64 K179-ub ENTQTTIkLFQECCP
0 1 K198 RVVLIGGKPDRVVEC
0 72 K198-ub RVVLIGGkPDRVVEC
0 2 K207-ub DRVVECIkIILDLIs
0 8 S214-p kIILDLIsEsPIkGR
4 45 S216-p ILDLIsEsPIkGRAQ
0 1 K219-ac LIsEsPIkGRAQPyD
0 86 K219-ub LIsEsPIkGRAQPyD
0 1 K219-sc LIsEsPIkGRAQPyD
1 2 Y225-p IkGRAQPyDPNFyDE
1 3 Y230-p QPyDPNFyDETyDyG
1 1 Y234-p PNFyDETyDyGGFTM
1 1 Y236-p FyDETyDyGGFTMMF
0 1 R246-m1 FTMMFDDrrGrPVGF
0 1 R247-m1 TMMFDDrrGrPVGFP
0 1 R249 MFDDrrGRPVGFPMr
0 1 R249-m2 MFDDrrGrPVGFPMr
1 5 R256-m1 rPVGFPMrGrGGFDr
1 2 R256-m2 rPVGFPMrGrGGFDr
1 2 R258-m1 VGFPMrGrGGFDrMP
1 1 R258-m2 VGFPMrGrGGFDrMP
0 1 R263-m1 rGrGGFDrMPPGrGG
1 1 R268-m1 FDrMPPGrGGrPMPP
0 2 R268-m2 FDrMPPGrGGrPMPP
0 1 R271-m1 MPPGrGGrPMPPsrR
0 1 S276-p GGrPMPPsrRDyDDM
0 1 R277-m1 GrPMPPsrRDyDDMs
0 162 Y280-p MPPsrRDyDDMsPrR
6 227 S284-p rRDyDDMsPrRGPPP
0 3 R286-m1 DyDDMsPrRGPPPPP
1 11 R296-m1 PPPPPPGrGGrGGsr
2 10 R296-m2 PPPPPPGrGGrGGsr
1 12 R299-m1 PPPGrGGrGGsrArN
2 12 R299-m2 PPPGrGGrGGsrArN
4 0 S302-p GrGGrGGsrArNLPL
0 11 R303-m1 rGGrGGsrArNLPLP
1 3 R303-m2 rGGrGGsrArNLPLP
0 5 R305-m1 GrGGsrArNLPLPPP
0 26 R316-m1 LPPPPPPrGGDLMAy
0 284 Y323-p rGGDLMAyDrRGrPG
0 12 R325-m1 GDLMAyDrRGrPGDR
0 1 R328-m1 MAyDrRGrPGDRyDG
0 7 Y333-p RGrPGDRyDGMVGFS
4 1 S353-p DSAIDTWsPSEWQMA
0 7 Y361-p PSEWQMAyEPQGGSG
0 86 Y369-p EPQGGSGydysyAGG
0 1 D370-ca PQGGSGydysyAGGR
0 149 Y371-p QGGSGydysyAGGRG
0 4 S372-p GGSGydysyAGGRGs
0 2 Y373-p GSGydysyAGGRGsy
0 1 R377 dysyAGGRGsyGDLG
0 29 S379-p syAGGRGsyGDLGGP
2 35 Y380-p yAGGRGsyGDLGGPI
0 1 T389-p DLGGPIIttQVtIPk
0 2 T390-p LGGPIIttQVtIPkD
0 1 T393-p PIIttQVtIPkDLAG
0 11 K396-ub ttQVtIPkDLAGsII
0 5 S401-p IPkDLAGsIIGkGGQ
0 89 K405-ub LAGsIIGkGGQRIKQ
0 1 K405-sc LAGsIIGkGGQRIKQ
0 1 S417-p IKQIRHEsGAsIkID
0 4 S420-p IRHEsGAsIkIDEPL
0 1 K422-ac HEsGAsIkIDEPLEG
0 78 K422-ub HEsGAsIkIDEPLEG
1 1 K422-sm HEsGAsIkIDEPLEG
0 1 K422-sc HEsGAsIkIDEPLEG
0 1 S430-p IDEPLEGsEDRIItI
0 1 T436-p GsEDRIItITGtQDQ
0 7 T440-p RIItITGtQDQIQNA
0 47 Y449-p DQIQNAQyLLQNsVk
0 3 S454-p AQyLLQNsVkQySGk
0 21 K456-ub yLLQNsVkQySGkFF
1 20 Y458-p LQNsVkQySGkFF__
0 2 K461-ac sVkQySGkFF_____
0 4 K461-ub sVkQySGkFF_____
  hnRNP K iso2  
T3 _____METEQPEETF
K21 ETNGEFGKRPAEDME
R22 TNGEFGKRPAEDMEE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
S36 EEQAFKRSRNTDEMV
T39 AFKRSRNTDEMVELR
R46 TDEMVELRILLQSKN
K52 LRILLQSKNAGAVIG
K52 LRILLQSKNAGAVIG
K60-ub NAGAVIGkGGKNIKA
K66 GkGGKNIKALRTDYN
T70 KNIKALRTDYNASVS
Y72 IKALRTDYNASVSVP
S75 LRTDYNASVSVPDSS
S77 TDYNASVSVPDSSGP
S81 ASVSVPDSSGPERIL
S91 PERILSISADIETIG
T96 SISADIETIGEILKK
K102 ETIGEILKKIIPTLE
K103 TIGEILKKIIPTLEE
S116-p EEGLQLPsPTATSQL
T118 GLQLPsPTATSQLPL
T120 QLPsPTATSQLPLES
S121 LPsPTATSQLPLESD
S127 TSQLPLESDAVECLN
D128 SQLPLESDAVECLNY
Y135 DAVECLNYQHYKGSD
Y138 ECLNYQHYKGSDFDC
S141 NYQHYKGSDFDCELR
S154 LRLLIHQSLAGGIIG
K163 AGGIIGVKGAKIKEL
K166 IIGVKGAKIKELREN
K179 ENTQTTIKLFQECCP
K198 RVVLIGGKPDRVVEC
K198 RVVLIGGKPDRVVEC
K207 DRVVECIKIILDLIS
S214 KIILDLISESPIkGR
S216 ILDLISESPIkGRAQ
K219-ac LISESPIkGRAQPYD
K219 LISESPIKGRAQPYD
K219 LISESPIKGRAQPYD
Y225 IkGRAQPYDPNFYDE
Y230 QPYDPNFYDETYDYG
Y234 PNFYDETYDYGGFTM
Y236 FYDETYDYGGFTMMF
R246 FTMMFDDRRGRPVGF
R247 TMMFDDRRGRPVGFP
R249 MFDDRRGRPVGFPMR
R249 MFDDRRGRPVGFPMR
R256 RPVGFPMRGRGGFDR
R256 RPVGFPMRGRGGFDR
R258 VGFPMRGRGGFDRMP
R258 VGFPMRGRGGFDRMP
R263 RGRGGFDRMPPGRGG
R268 FDRMPPGRGGRPMPP
R268 FDRMPPGRGGRPMPP
R271 MPPGRGGRPMPPSRR
S276 GGRPMPPSRRDYDDM
R277 GRPMPPSRRDYDDMs
Y280 MPPSRRDYDDMsPRR
S284-p RRDYDDMsPRRGPPP
R286 DYDDMsPRRGPPPPP
R296 PPPPPPGRGGRGGSR
R296 PPPPPPGRGGRGGSR
R299 PPPGRGGRGGSRARN
R299 PPPGRGGRGGSRARN
S302 GRGGRGGSRARNLPL
R303 RGGRGGSRARNLPLP
R303 RGGRGGSRARNLPLP
R305 GRGGSRARNLPLPPP
R316 LPPPPPPRGGDLMAY
Y323 RGGDLMAYDRRGRPG
R325 GDLMAYDRRGRPGDR
R328 MAYDRRGRPGDRYDG
Y333 RGRPGDRYDGMVGFS
S353 DSAIDTWSPSEWQMA
Y361 PSEWQMAYEPQGGSG
Y369 EPQGGSGYDYSYAGG
D370 PQGGSGYDYSYAGGR
Y371 QGGSGYDYSYAGGRG
S372 GGSGYDYSYAGGRGS
Y373 GSGYDYSYAGGRGSY
R377 DYSYAGGRGSYGDLG
S379 SYAGGRGSYGDLGGP
Y380 YAGGRGSYGDLGGPI
T389 DLGGPIITTQVTIPK
T390 LGGPIITTQVTIPKD
T393 PIITTQVTIPKDLAG
K396 TTQVTIPKDLAGSII
S401 IPKDLAGSIIGkGGQ
K405-ub LAGSIIGkGGQRIKQ
K405 LAGSIIGKGGQRIKQ
S417 IKQIRHESGASIKID
S420 IRHESGASIKIDEPL
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
S430 IDEPLEGSEDRIITI
T436 GSEDRIITITGTQDQ
T440 RIITITGTQDQIQNA
Y449-p DQIQNAQyLLQNsVk
S454-p AQyLLQNsVkQyADV
K456-ub yLLQNsVkQyADVEG
Y458-p LQNsVkQyADVEGF_
- gap
- gap
  mouse

► Hide Isoforms
 
T3-p _____MEtEQPEETF
K21 ETNGEFGKRPAEDME
R22 TNGEFGKRPAEDMEE
K34-ac MEEEQAFkRsRNtDE
K34-ub MEEEQAFkRsRNtDE
K34-sc MEEEQAFkRsRNtDE
S36-p EEQAFkRsRNtDEMV
T39-p AFkRsRNtDEMVELR
R46 tDEMVELRILLQSkN
K52-ub LRILLQSkNAGAVIG
K52 LRILLQSKNAGAVIG
K60-ub NAGAVIGkGGKNIkA
K66-ub GkGGKNIkALRtDyN
T70-p KNIkALRtDyNAsVs
Y72-p IkALRtDyNAsVsVP
S75-p LRtDyNAsVsVPDsS
S77-p tDyNAsVsVPDsSGP
S81-p AsVsVPDsSGPERIL
S91-p PERILSIsADIEtIG
T96-p SIsADIEtIGEILKK
K102 EtIGEILKKIIPTLE
K103 tIGEILKKIIPTLEE
S116-p EEGLQLPsPtAtsQL
T118-p GLQLPsPtAtsQLPL
T120-p QLPsPtAtsQLPLEs
S121-p LPsPtAtsQLPLEsD
S127-p tsQLPLEsDAVECLN
D128 sQLPLEsDAVECLNY
Y135 DAVECLNYQHyKGSD
Y138-p ECLNYQHyKGSDFDC
S141 NYQHyKGSDFDCELR
S154 LRLLIHQSLAGGIIG
K163-ub AGGIIGVkGAkIKEL
K166-ub IIGVkGAkIKELREN
K179-ub ENTQTTIkLFQECCP
K198-ac RVVLIGGkPDRVVEC
K198-ub RVVLIGGkPDRVVEC
K207 DRVVECIKIILDLIS
S214 KIILDLISEsPIkGR
S216-p ILDLISEsPIkGRAQ
K219 LISEsPIKGRAQPYD
K219-ub LISEsPIkGRAQPYD
K219 LISEsPIKGRAQPYD
Y225 IkGRAQPYDPNFYDE
Y230 QPYDPNFYDETYDYG
Y234 PNFYDETYDYGGFTM
Y236 FYDETYDYGGFTMMF
R246 FTMMFDDRRGrPVGF
R247 TMMFDDRRGrPVGFP
R249-m1 MFDDRRGrPVGFPMr
R249 MFDDRRGRPVGFPMr
R256-m1 rPVGFPMrGrGGFDR
R256 rPVGFPMRGrGGFDR
R258-m1 VGFPMrGrGGFDRMP
R258 VGFPMrGRGGFDRMP
R263 rGrGGFDRMPPGRGG
R268 FDRMPPGRGGRPMPP
R268 FDRMPPGRGGRPMPP
R271 MPPGRGGRPMPPSRR
S276 GGRPMPPSRRDyDDM
R277 GRPMPPSRRDyDDMs
Y280-p MPPSRRDyDDMsPRR
S284-p RRDyDDMsPRRGPPP
R286 DyDDMsPRRGPPPPP
R296-m1 PPPPPPGrGGrGGsr
R296-m2 PPPPPPGrGGrGGsr
R299-m1 PPPGrGGrGGsrARN
R299-m2 PPPGrGGrGGsrARN
S302-p GrGGrGGsrARNLPL
R303-m1 rGGrGGsrARNLPLP
R303-m2 rGGrGGsrARNLPLP
R305 GrGGsrARNLPLPPP
R316-m1 LPPPPPPrGGDLMAy
Y323-p rGGDLMAyDrRGRPG
R325-m1 GDLMAyDrRGRPGDR
R328 MAyDrRGRPGDRYDG
Y333 RGRPGDRYDGMVGFS
S353-p DSAIDTWsPSEWQMA
Y361 PSEWQMAYEPQGGSG
Y369 EPQGGSGYDySYAGG
D370 PQGGSGYDySYAGGr
Y371-p QGGSGYDySYAGGrG
S372 GGSGYDySYAGGrGs
Y373 GSGYDySYAGGrGsy
R377-m1 DySYAGGrGsyGDLG
S379-p SYAGGrGsyGDLGGP
Y380-p YAGGrGsyGDLGGPI
- under review  
T390 LGGPIITTQVTIPkD
- under review  
K396-ub TTQVTIPkDLAGSII
S401 IPkDLAGSIIGkGGQ
K405-ub LAGSIIGkGGQRIKQ
K405 LAGSIIGKGGQRIKQ
S417 IKQIRHESGASIkID
S420 IRHESGASIkIDEPL
K422 HESGASIKIDEPLEG
K422-ub HESGASIkIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
S430 IDEPLEGSEDRIITI
T436 GSEDRIITITGTQDQ
T440 RIITITGTQDQIQNA
Y449-p DQIQNAQyLLQNSVk
S454 AQyLLQNSVkQYSGk
K456-ub yLLQNSVkQYSGkFF
Y458 LQNSVkQYSGkFF__
K461 SVkQYSGKFF_____
K461-ub SVkQYSGkFF_____
  hnRNP K iso2  
T3 _____METEQPEETF
K21 ETNGEFGKRPAEDME
R22 TNGEFGKRPAEDMEE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
S36 EEQAFKRSRNTDEMV
T39 AFKRSRNTDEMVELR
R46 TDEMVELRILLQSKN
K52 LRILLQSKNAGAVIG
K52 LRILLQSKNAGAVIG
K60 NAGAVIGKGGKNIKA
K66 GKGGKNIKALRTDYN
T70 KNIKALRTDYNASVS
Y72 IKALRTDYNASVSVP
S75 LRTDYNASVSVPDSS
S77 TDYNASVSVPDSSGP
S81 ASVSVPDSSGPERIL
S91 PERILSISADIETIG
T96 SISADIETIGEILKK
K102 ETIGEILKKIIPTLE
K103 TIGEILKKIIPTLEE
S116-p EEGLQLPsPTATSQL
T118 GLQLPsPTATSQLPL
T120 QLPsPTATSQLPLES
S121 LPsPTATSQLPLESD
S127 TSQLPLESDAVECLN
D128 SQLPLESDAVECLNY
Y135 DAVECLNYQHYKGSD
Y138 ECLNYQHYKGSDFDC
S141 NYQHYKGSDFDCELR
S154 LRLLIHQSLAGGIIG
K163 AGGIIGVKGAKIKEL
K166 IIGVKGAKIKELREN
K179 ENTQTTIKLFQECCP
K198 RVVLIGGKPDRVVEC
K198 RVVLIGGKPDRVVEC
K207 DRVVECIKIILDLIS
S214 KIILDLISESPIKGR
S216 ILDLISESPIKGRAQ
K219 LISESPIKGRAQPYD
K219 LISESPIKGRAQPYD
K219 LISESPIKGRAQPYD
Y225 IKGRAQPYDPNFYDE
Y230 QPYDPNFYDETYDYG
Y234 PNFYDETYDYGGFTM
Y236 FYDETYDYGGFTMMF
R246 FTMMFDDRRGRPVGF
R247 TMMFDDRRGRPVGFP
R249 MFDDRRGRPVGFPMR
R249 MFDDRRGRPVGFPMR
R256 RPVGFPMRGRGGFDR
R256 RPVGFPMRGRGGFDR
R258 VGFPMRGRGGFDRMP
R258 VGFPMRGRGGFDRMP
R263 RGRGGFDRMPPGRGG
R268 FDRMPPGRGGRPMPP
R268 FDRMPPGRGGRPMPP
R271 MPPGRGGRPMPPSRR
S276 GGRPMPPSRRDYDDM
R277 GRPMPPSRRDYDDMs
Y280 MPPSRRDYDDMsPRR
S284-p RRDYDDMsPRRGPPP
R286 DYDDMsPRRGPPPPP
R296 PPPPPPGRGGRGGSR
R296 PPPPPPGRGGRGGSR
R299 PPPGRGGRGGSRARN
R299 PPPGRGGRGGSRARN
S302 GRGGRGGSRARNLPL
R303 RGGRGGSRARNLPLP
R303 RGGRGGSRARNLPLP
R305 GRGGSRARNLPLPPP
R316 LPPPPPPRGGDLMAY
Y323 RGGDLMAYDRRGRPG
R325 GDLMAYDRRGRPGDR
R328 MAYDRRGRPGDRYDG
Y333 RGRPGDRYDGMVGFS
S353-p DSAIDTWsPSEWQMA
Y361 PSEWQMAYEPQGGSG
Y369 EPQGGSGYDYSYAGG
D370 PQGGSGYDYSYAGGR
Y371 QGGSGYDYSYAGGRG
S372 GGSGYDYSYAGGRGS
Y373 GSGYDYSYAGGRGSY
R377 DYSYAGGRGSYGDLG
S379 SYAGGRGSYGDLGGP
Y380 YAGGRGSYGDLGGPI
- under review  
T390 LGGPIITTQVTIPKD
- under review  
K396 TTQVTIPKDLAGSII
S401 IPKDLAGSIIGKGGQ
K405 LAGSIIGKGGQRIKQ
K405 LAGSIIGKGGQRIKQ
S417 IKQIRHESGASIKID
S420 IRHESGASIKIDEPL
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
S430 IDEPLEGSEDRIITI
T436 GSEDRIITITGTQDQ
T440 RIITITGTQDQIQNA
Y449 DQIQNAQYLLQNSVK
S454 AQYLLQNSVKQYADV
K456 YLLQNSVKQYADVEG
Y458 LQNSVKQYADVEGF_
- gap
- gap
  hnRNP K iso4  
T3 _____METEQPEETF
E21 ETNGEFGERPAEDME
R22 TNGEFGERPAEDMEE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
S36 EEQAFKRSRNTDEMV
T39 AFKRSRNTDEMVELR
R46 TDEMVELRILLQSKN
K52 LRILLQSKNAGAVIG
K52 LRILLQSKNAGAVIG
K60 NAGAVIGKGGKNIKA
K66 GKGGKNIKALRTDYN
T70 KNIKALRTDYNASVS
Y72 IKALRTDYNASVSVP
S75 LRTDYNASVSVPDSS
S77 TDYNASVSVPDSSGP
S81 ASVSVPDSSGPERIL
S91 PERILSISADIETIG
T96 SISADIETIGEILKK
K102 ETIGEILKKIIPTLE
K103 TIGEILKKIIPTLEE
- gap
- gap
- gap
- gap
- gap
- gap
Y111 IIPTLEEYQHYKGSD
Y114 TLEEYQHYKGSDFDC
S117 EYQHYKGSDFDCELR
S130 LRLLIHQSLAGGIIG
K139 AGGIIGVKGAKIKEL
K142 IIGVKGAKIKELREN
K155 ENTQTTIKLFQECCP
K174 RVVLIGGKPDRVVEC
K174 RVVLIGGKPDRVVEC
K183 DRVVECIKIILDLIS
S190 KIILDLISESPIKGR
S192 ILDLISESPIKGRAQ
K195 LISESPIKGRAQPYD
K195 LISESPIKGRAQPYD
K195 LISESPIKGRAQPYD
Y201 IKGRAQPYDPNFYDE
Y206 QPYDPNFYDETYDYG
Y210 PNFYDETYDYGGFTM
Y212 FYDETYDYGGFTMMF
R222 FTMMFDDRRGRPVGF
R223 TMMFDDRRGRPVGFP
R225 MFDDRRGRPVGFPMR
R225 MFDDRRGRPVGFPMR
R232 RPVGFPMRGRGGFDR
R232 RPVGFPMRGRGGFDR
R234 VGFPMRGRGGFDRMP
R234 VGFPMRGRGGFDRMP
R239 RGRGGFDRMPPGRGG
R244 FDRMPPGRGGRPMPP
R244 FDRMPPGRGGRPMPP
R247 MPPGRGGRPMPPSRR
S252 GGRPMPPSRRDYDDM
R253 GRPMPPSRRDYDDMS
Y256 MPPSRRDYDDMSPRR
S260 RRDYDDMSPRRGPPP
R262 DYDDMSPRRGPPPPP
R272 PPPPPPGRGGRGGSR
R272 PPPPPPGRGGRGGSR
R275 PPPGRGGRGGSRARN
R275 PPPGRGGRGGSRARN
S278 GRGGRGGSRARNLPL
R279 RGGRGGSRARNLPLP
R279 RGGRGGSRARNLPLP
R281 GRGGSRARNLPLPPP
R292 LPPPPPPRGGDLMAY
Y299 RGGDLMAYDRRGRPG
R301 GDLMAYDRRGRPGDR
R304 MAYDRRGRPGDRYDG
Y309 RGRPGDRYDGMVGFS
S329 DSAIDTWSPSEWQMA
Y337 PSEWQMAYEPQGGSG
Y345 EPQGGSGYDYSYAGG
D346 PQGGSGYDYSYAGGR
Y347 QGGSGYDYSYAGGRG
S348 GGSGYDYSYAGGRGS
Y349 GSGYDYSYAGGRGSY
R353 DYSYAGGRGSYGDLG
S355 SYAGGRGSYGDLGGP
Y356 YAGGRGSYGDLGGPI
T365 DLGGPIITTQVTIPK
T366 LGGPIITTQVTIPKD
T369 PIITTQVTIPKDLAG
K372 TTQVTIPKDLAGSII
S377 IPKDLAGSIIGKGGQ
K381 LAGSIIGKGGQRIKQ
K381 LAGSIIGKGGQRIKQ
S393 IKQIRHESGASIKID
S396 IRHESGASIKIDEPL
K398 HESGASIKIDEPLEG
K398 HESGASIKIDEPLEG
K398 HESGASIKIDEPLEG
K398 HESGASIKIDEPLEG
S406 IDEPLEGSEDRIITI
T412 GSEDRIITITGTQDQ
T416 RIITITGTQDQIQNA
Y425 DQIQNAQYLLQNSVK
S450-p RYFFFFYsVKQYSGK
K452 FFFFYsVKQYSGKFF
Y454 FFYsVKQYSGKFF__
K457 sVKQYSGKFF_____
K457 sVKQYSGKFF_____
  rat

 
T3 _____METEQPEETF
K21-ac ETNGEFGkRPAEDME
R22 TNGEFGkRPAEDMEE
K34-ac MEEEQAFkRSRNTDE
K34 MEEEQAFKRSRNTDE
K34 MEEEQAFKRSRNTDE
S36 EEQAFkRSRNTDEMV
T39 AFkRSRNTDEMVELR
R46 TDEMVELRILLQSKN
K52 LRILLQSKNAGAVIG
K52 LRILLQSKNAGAVIG
K60 NAGAVIGKGGKNIKA
K66 GKGGKNIKALRTDYN
T70 KNIKALRTDYNASVS
Y72 IKALRTDYNASVSVP
S75 LRTDYNASVSVPDSS
S77 TDYNASVSVPDSSGP
S81 ASVSVPDSSGPERIL
S91 PERILSISADIETIG
T96 SISADIETIGEILKK
K102 ETIGEILKKIIPTLE
K103 TIGEILKKIIPTLEE
S116-p EEGLQLPsPTATSQL
T118 GLQLPsPTATSQLPL
T120 QLPsPTATSQLPLES
S121 LPsPTATSQLPLESD
S127 TSQLPLESDAVECLN
D128 SQLPLESDAVECLNY
Y135 DAVECLNYQHYKGSD
Y138 ECLNYQHYKGSDFDC
S141 NYQHYKGSDFDCELR
S154 LRLLIHQSLAGGIIG
K163 AGGIIGVKGAKIKEL
K166 IIGVKGAKIKELREN
K179 ENTQTTIKLFQECCP
K198 RVVLIGGKPDRVVEC
K198 RVVLIGGKPDRVVEC
K207 DRVVECIKIILDLIS
S214 KIILDLISEsPIkGR
S216-p ILDLISEsPIkGRAQ
K219 LISEsPIKGRAQPyD
K219-ub LISEsPIkGRAQPyD
K219 LISEsPIKGRAQPyD
Y225-p IkGRAQPyDPNFyDE
Y230-p QPyDPNFyDETYDYG
Y234 PNFyDETYDYGGFTM
Y236 FyDETYDYGGFTMMF
R246 FTMMFDDRRGRPVGF
R247 TMMFDDRRGRPVGFP
R249 MFDDRRGRPVGFPMR
R249 MFDDRRGRPVGFPMR
R256 RPVGFPMRGRGGFDR
R256 RPVGFPMRGRGGFDR
R258 VGFPMRGRGGFDRMP
R258 VGFPMRGRGGFDRMP
R263 RGRGGFDRMPPGRGG
R268 FDRMPPGRGGRPMPP
R268 FDRMPPGRGGRPMPP
R271 MPPGRGGRPMPPSRR
S276 GGRPMPPSRRDYDDM
R277 GRPMPPSRRDYDDMs
Y280 MPPSRRDYDDMsPrR
S284-p RRDYDDMsPrRGPPP
R286-m1 DYDDMsPrRGPPPPP
R296-m1 PPPPPPGrGGrGGSr
R296 PPPPPPGRGGrGGSr
R299-m1 PPPGrGGrGGSrARN
R299 PPPGrGGRGGSrARN
S302 GrGGrGGSrARNLPL
R303-m1 rGGrGGSrARNLPLP
R303 rGGrGGSRARNLPLP
R305 GrGGSrARNLPLPPP
R316-m1 LPPPPPPrGGDLMAY
Y323 rGGDLMAYDrRGRPG
R325-m1 GDLMAYDrRGRPGDR
R328 MAYDrRGRPGDRYDG
Y333 RGRPGDRYDGMVGFS
S353 DSAIDTWSPSEWQMA
Y361 PSEWQMAYEPQGGSG
Y369 EPQGGSGYDYSYAGG
D370 PQGGSGYDYSYAGGR
Y371 QGGSGYDYSYAGGRG
S372 GGSGYDYSYAGGRGs
Y373 GSGYDYSYAGGRGsY
R377 DYSYAGGRGsYGDLG
S379-p SYAGGRGsYGDLGGP
Y380 YAGGRGsYGDLGGPI
- under review  
T390 LGGPIITTQVTIPKD
- under review  
K396 TTQVTIPKDLAGsII
S401-p IPKDLAGsIIGKGGQ
K405 LAGsIIGKGGQRIKQ
K405 LAGsIIGKGGQRIKQ
S417 IKQIRHESGASIKID
S420 IRHESGASIKIDEPL
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
K422 HESGASIKIDEPLEG
S430 IDEPLEGSEDRIITI
T436 GSEDRIITITGTQDQ
T440 RIITITGTQDQIQNA
Y449 DQIQNAQYLLQNSVK
S454 AQYLLQNSVKQYSGk
K456 YLLQNSVKQYSGkFF
Y458 LQNSVKQYSGkFF__
K461-ac SVKQYSGkFF_____
K461 SVKQYSGKFF_____
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