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HDAC5 (human)

Overview HDAC5 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Hydrolase; EC 3.5.1.98 Cellular Component: nuclear body; Golgi apparatus; cytoplasm; histone deacetylase complex; nucleolus; nucleus; cytosol Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity; transcription factor binding Biological Process: Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; B cell activation; heart development; chromatin silencing; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; osteoblast development; chromatin remodeling; cellular response to insulin stimulus; regulation of protein binding; B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast differentiation; positive regulation of transcription factor activity; inflammatory response; negative regulation of transcription, DNA-dependent Reference #:  Q9UQL6 (UniProtKB) Alt. Names/Synonyms: Antigen NY-CO-9; FLJ90614; HD5; HDAC5; Histone deacetylase 5; KIAA0600; NY-CO-9 Gene Symbols: HDAC5 Molecular weight: 121,978 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC5

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	Sites Implicated In
cell differentiation, altered: S259‑p, S498‑p cell motility, altered: S259‑p, S498‑p chromatin organization, altered: S259‑p, S498‑p transcription, altered: S259‑p, S279‑p, S498‑p enzymatic activity, induced: S278‑p, S279‑p enzymatic activity, inhibited: S259‑p, S498‑p intracellular localization: S259‑p, S279‑p, S498‑p, S661‑p molecular association, regulation: S259‑p, S278‑p, S279‑p, S498‑p protein conformation: S279‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S3-p	_____MNsPNEsDGM
0	1		S7-p	_MNsPNEsDGMSGRE
0	1		S53-p	MGGGGGGsPsPVELR
0	1		S55-p	GGGGGsPsPVELRGA
0	1		S66-p	LRGALVGsVDPtLRE
0	1		T70-p	LVGsVDPtLREQQLQ
0	1		S180-p	SKESAIAstEVKLRL
0	1		T181-p	KESAIAstEVKLRLQ
0	1		S206-p	TPGGLNHsLPQHPKC
0	1		T234-p	PQSGPPGtPPSYKLP
15	22		S259-p	FPLRKTAsEPNLKVR
2	5		S278-p	QKVAERRssPLLRRK
5	7		S279-p	KVAERRssPLLRRKD
0	1		T288-p	LLRRKDGtVIstFKK
0	1		S291-p	RKDGtVIstFKKRAV
1	1		T292-p	KDGtVIstFKKRAVE
0	1		S368-p	FSLYTSPsLPNISLG
0	2		T496-p	RHRPLSRtQsSPLPQ
17	6		S498-p	RPLSRtQsSPLPQsP
0	1		S504-p	QsSPLPQsPQALQQL
0	2		K533-a	QQQLQLGkILTKTGE
0	9		T546-p	GELPRQPttHPEETE
0	4		T547-p	ELPRQPttHPEETEE
1	5		S611-p	VKDEEGEsGAEEGPD
1	15		S661-p	QALGRTQsSPAAPGG
0	2		S671-p	AAPGGMKsPPDQPVK
1	1		S755-p	HTLLYGTsPLNRQKL
0	1		Y776-p	GPISQKMyAVLPCGG
0	1		S798-p	VWNEMHSssAVRMAV
0	1		S799-p	WNEMHSssAVRMAVG
0	2		S1071-p	FAAGLGRsLREAQAG
1	2		S1108-p	AAAAREHsPRPAEEP

	mouse
S3	_____MNSPNESDGM
S7	_MNSPNESDGMSGRE
S53	MGGGGGGSPSPVELR
S55	GGGGGSPSPVELRGA
P66	LRGALAGPMDPALRE
A70	LAGPMDPALREQQLQ
S171	SKESAIASTEVKLRL
T172	KESAIASTEVKLRLQ
S197	TPGGLNHSLPQHPKC
T225	PQSGPPGTPPSYKLP
S250-p	FPLRKTAsEPNLKVR
S269-p	QKVAERRssPLLRRK
S270-p	KVAERRssPLLRRKD
T279	LLRRKDGTVISTFKK
S282	RKDGTVISTFKKRAV
T283	KDGTVISTFKKRAVE
S359	FSLYTSPSLPNISLG
T486-p	RHRPLSRtQsSPLPQ
S488-p	RPLSRtQsSPLPQSP
S494	QsSPLPQSPQALQQL
K523	QQQMQLGKILTKTGE
T536-p	GELSRQPtTHPEETE
T537	ELSRQPtTHPEETEE
S600-p	VKDEDGEsGPDEGPD
S650-p	QALGRTQsSPAAPGS
S660-p	AAPGSMKsPTDQPTV
S746	HTLLYGTSPLNRQKL
Y767	GPISQKMYAMLPCGG
S789	VWNEMHSSSAVRMAV
S790	WNEMHSSSAVRMAVG
S1062-p	FAAGLGCsLREAQTG
S1099	AVATQEHSPRPAEEP

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