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Protein Page:
HDAC5 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC5 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Coimmunoprecipitates only with HDAC3 family members. Interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.5.1.98
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: nucleoplasm; Golgi apparatus; nuclear body; histone deacetylase complex; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity; transcription factor binding
Biological Process: response to drug; establishment and/or maintenance of chromatin architecture; Notch signaling pathway; regulation of skeletal muscle fiber development; B cell activation; transcription, DNA-dependent; heart development; chromatin silencing; histone deacetylation; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; osteoblast development; chromatin remodeling; cellular response to insulin stimulus; B cell differentiation; regulation of protein binding; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast differentiation; inflammatory response; negative regulation of transcription, DNA-dependent; multicellular organismal response to stress
Reference #:  Q9UQL6 (UniProtKB)
Alt. Names/Synonyms: Antigen NY-CO-9; FLJ90614; HD5; HDAC5; Histone deacetylase 5; KIAA0600; NY-CO-9
Gene Symbols: HDAC5
Molecular weight: 121,978 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC5

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: S259‑p, S498‑p
cell cycle regulation: S259‑p, S498‑p
cell differentiation, altered: S259‑p, S498‑p
cell motility, altered: S259‑p, S498‑p
chromatin organization, altered: S259‑p, S498‑p
transcription, altered: S259‑p, S498‑p
transcription, induced: S259‑p, S498‑p
transcription, inhibited: S279‑p
enzymatic activity, induced: S278‑p, S279‑p
enzymatic activity, inhibited: S259‑p, S498‑p
intracellular localization: S259‑p, S279‑p, S498‑p, S661‑p
molecular association, regulation: S259‑p, S278‑p, S279‑p, S498‑p
protein conformation: S279‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MNsPNEsDGM
0 1 S7-p _MNsPNEsDGMSGRE
0 1 S53-p MGGGGGGsPsPVELR
0 1 S55-p GGGGGsPsPVELRGA
0 1 S66-p LRGALVGsVDPtLRE
0 1 T70-p LVGsVDPtLREQQLQ
0 1 S180-p SKESAIAstEVKLRL
0 1 T181-p KESAIAstEVKLRLQ
0 1 S206-p TPGGLNHsLPQHPKC
0 1 T234-p PQSGPPGtPPSYKLP
19 29 S259-p FPLRKTAsEPNLKVR
2 9 S278-p QKVAERRssPLLRRK
5 11 S279-p KVAERRssPLLRRKD
0 1 T288-p LLRRKDGtVIstFKK
0 1 S291-p RKDGtVIstFKKRAV
1 1 T292-p KDGtVIstFKKRAVE
0 1 S368-p FSLYTSPsLPNISLG
0 1 S469-p AVPLHGQsPLVTGER
0 2 T496-p RHRPLSRtQsSPLPQ
20 7 S498-p RPLSRtQsSPLPQsP
0 1 S504-p QsSPLPQsPQALQQL
0 2 K533-ac QQQLQLGkILTKTGE
0 9 T546-p GELPRQPttHPEETE
0 4 T547-p ELPRQPttHPEETEE
2 10 S611-p VKDEEGEsGAEEGPD
1 31 S661-p QALGRTQsSPAAPGG
0 4 S671-p AAPGGMKsPPDQPVK
0 1 P673 PGGMKsPPDQPVKHL
2 1 S755-p HTLLYGTsPLNRQKL
0 1 Y776-p GPISQKMyAVLPCGG
0 1 S798-p VWNEMHSssAVRMAV
0 1 S799-p WNEMHSssAVRMAVG
0 2 S1071-p FAAGLGRsLREAQAG
2 3 S1108-p AAAAREHsPRPAEEP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  mouse

 
S3 _____MNSPNESDGM
S7 _MNSPNESDGMSGRE
S53 MGGGGGGSPSPVELR
S55 GGGGGSPSPVELRGA
P66 LRGALAGPMDPALRE
A70 LAGPMDPALREQQLQ
S171 SKESAIASTEVKLRL
T172 KESAIASTEVKLRLQ
S197 TPGGLNHSLPQHPKC
T225 PQSGPPGTPPSYKLP
S250-p FPLRKTAsEPNLKVR
S269-p QKVAERRssPLLRRK
S270-p KVAERRssPLLRRKD
T279 LLRRKDGTVISTFKK
S282 RKDGTVISTFKKRAV
T283 KDGTVISTFKKRAVE
S359 FSLYTSPSLPNISLG
S459 AVPLHGQSPLVTGER
T486-p RHRPLSRtQsSPLPQ
S488-p RPLSRtQsSPLPQSP
S494 QsSPLPQSPQALQQL
K523 QQQMQLGKILTKTGE
T536-p GELSRQPtTHPEETE
T537 ELSRQPtTHPEETEE
S600-p VKDEDGEsGPDEGPD
S650-p QALGRTQsSPAAPGS
S660-p AAPGSMKsPtDQPTV
T662-p PGSMKsPtDQPTVVK
S746 HTLLYGTSPLNRQKL
Y767 GPISQKMYAMLPCGG
S789 VWNEMHSSSAVRMAV
S790 WNEMHSSSAVRMAVG
S1062-p FAAGLGCsLREAQTG
S1099 AVATQEHSPRPAEEP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____AIASTEVKLRL
T5 ___AIASTEVKLRLQ
S30 TPGGLNHSLPQHPKC
T58 PQSGPPGTPPSYKLP
S83 FPLRKTASEPNLKVR
S102-p QKVAERRssPLLRRK
S103-p KVAERRssPLLRRKD
T112 LLRRKDGTVISTFKK
S115 RKDGTVISTFKKRAV
T116 KDGTVISTFKKRAVE
S192 FSLYTSPSLPNISLG
S293 AVPLHGQSPLVTGER
T320 RHRPLSRTQSSPLPQ
S322 RPLSRTQSSPLPQSP
S328 QSSPLPQSPQALQQL
K357 QQQMQLGKILTKTGE
T370 GELSRQPTTHPEETE
T371 ELSRQPTTHPEETEE
S433-p VKDEDGEsGPDEGAD
S483 QALGRTQSSPAAPGS
S493 AAPGSMKSPTDHPTV
T495 PGSMKSPTDHPTVER
S579 HTLLYGTSPLNRQKL
Y600 GPISQKMYAMLPCGG
S622 VWNEMHSSSAVRMAV
S623 WNEMHSSSAVRMAVG
S895 FATGLGCSLREAQTG
S932 AAATQEHSPRPAEEP
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