a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; Hydrolase; Nuclear receptor co-regulator; EC 184.108.40.206
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: transcriptional repressor complex; histone deacetylase complex; cytoplasm; actomyosin; nucleus; cytosol; neuromuscular junction; Z disc; A band
Molecular Function: potassium ion binding; transcription activator binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; transcription factor binding; protein kinase binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity
Biological Process: cardiac muscle hypertrophy; response to drug; nervous system development; regulation of skeletal muscle fiber development; B cell activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription factor activity; histone deacetylation; response to denervation involved in regulation of muscle adaptation; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; positive regulation of protein sumoylation; chromatin remodeling; negative regulation of cell proliferation; regulation of protein binding; B cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; negative regulation of glycolysis; inflammatory response; skeletal development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.