a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Deacetylase; Hydrolase; Nuclear receptor co-regulator
Cellular Component: transcriptional repressor complex; cytoplasm; histone deacetylase complex; actomyosin; nucleus; neuromuscular junction; Z disc; cytosol; A band
Molecular Function: potassium ion binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; transcription activator binding; zinc ion binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; histone deacetylase binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription factor binding; transcription corepressor activity; protein kinase binding
Biological Process: response to drug; cardiac muscle hypertrophy; nervous system development; regulation of skeletal muscle fiber development; transcription, DNA-dependent; B cell activation; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; histone deacetylation; response to denervation involved in regulation of muscle adaptation; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; chromatin remodeling; positive regulation of protein sumoylation; negative regulation of cell proliferation; regulation of protein binding; B cell differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of osteoblast differentiation; negative regulation of transcription, DNA-dependent; inflammatory response; negative regulation of glycolysis; skeletal development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.