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HDAC4 (human)

Overview HDAC4 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB. Protein type: Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Cellular Component: transcriptional repressor complex; cytoplasm; histone deacetylase complex; actomyosin; nucleus; cytosol; neuromuscular junction Molecular Function: potassium ion binding; transcription activator binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; protein kinase binding; transcription factor binding; NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity Biological Process: cardiac muscle hypertrophy; nervous system development; B cell activation; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; histone deacetylation; response to denervation involved in regulation of muscle adaptation; negative regulation of transcription from RNA polymerase II promoter; osteoblast development; chromatin remodeling; positive regulation of protein sumoylation; negative regulation of cell proliferation; regulation of protein binding; B cell differentiation; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of glycolysis; negative regulation of transcription, DNA-dependent; skeletal development Reference #:  P56524 (UniProtKB) Alt. Names/Synonyms: HA6116; HD4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288 Gene Symbols: HDAC4 Molecular weight: 119,040 Da Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states CST Pathways:  Cell Cycle: G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/ß-Catenin Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HDAC4 2H8N - A/B/C/D=61-153 (human) 2O94 - A/B/C/D=61-153 (human) 2VQJ - A=648-1057 (human) 2VQM - A=648-1057 (human) 2VQO - A/B=648-1057 (human) 2VQQ - A/B=648-1057 (human) 2VQV - A/B=648-1057 (human) 2VQW - G=648-1057 (human) 3UXG - B=343-359 (human) 3UZD - B=343-359 (human) 3V31 - B=343-359 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2H8N 2O94 2VQJ 2VQM 2VQO 2VQQ 2VQV 2VQW 3UXG 3UZD 3V31  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell motility, altered: S298‑p, S302‑p transcription, altered: S210‑p, S246‑p, S467‑p, S632‑p intracellular localization: S246‑p, S298‑p, S302‑p, S467‑p, S632‑p molecular association, regulation: S246‑p, S467‑p, S632‑p protein degradation: S298‑p, S302‑p ubiquitination: S298‑p, S302‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		S58-p	LRLDHQFsLPVAEPA
0	1		S168-p	GKESAVAsTEVkMKL
0	1		K172-a	AVAsTEVkMKLQEFV
0	1		S196	RNLNHCISSDPRYWY
1	2		S210-p	YGKTQHSsLDQSSPP
0	1		S215	HSsLDQSSPPQSGVS
0	1		K236-a	VLGMYDAkDDFPLRK
5	21		S246-p	FPLRKTAsEPNLKLR
1	4		S265-p	QKVAERRssPLLRRk
1	6		S266-p	KVAERRssPLLRRkD
0	1		K272-u	ssPLLRRkDGPVVtA
0	1		T278-p	RkDGPVVtALkkRPL
0	1		K281-u	GPVVtALkkRPLDVT
0	1		K282-u	PVVtALkkRPLDVTD
2	0		S298-p	ACSSAPGsGPSsPNN
1	0		S302-p	APGsGPSsPNNSSGS
0	1		S339-p	RLVAREGsAAPLPLY
0	1		S348-p	APLPLYTsPsLPNIT
1	3		S350-p	LPLYTsPsLPNITLG
0	1		S400-p	LTPYLSTsPLERDGG
0	2		T465-p	QHRPLGRtQsAPLPQ
3	20		S467-p	RPLGRtQsAPLPQNA
0	1		Y540-p	QALLDEPyLDRLPGQ
0	1		K548-a	LDRLPGQkEAHAQAG
1	0		K559-s	AQAGVQVkQEPIEsD
0	44		S565-p	VkQEPIEsDEEEAEP
4	70		S632-p	RPLSRAQssPAsAtF
0	9		S633-p	PLSRAQssPAsAtFP
0	3		S636-p	RAQssPAsAtFPVSV
0	1		T638-p	QssPAsAtFPVSVQE
0	1		S741-p	DSKKLLGsLAsVFVR
0	1		S744-p	KLLGsLAsVFVRLPC
0	1		S1025-p	EKVMEIHsKYWRCLQ
0	1		T1057-p	NEEAETVtAMAsLSV
0	1		S1061-p	ETVtAMAsLSVGVKP

	mouse
S58	LRLDHQFSLPLEPAL
S167	GKESAVASTEVkMKL
K171-a	AVASTEVkMKLQEFV
S195-p	RNLNHCIsSDPRYWY
S209-p	YGKTQHSsLDQSsPP
S214-p	HSsLDQSsPPQSGVS
K235	VLGMYDAKDDFPLRK
S245-p	FPLRKTAsEPNLKLR
S264-p	QKVAERRssPLLRRk
S265-p	KVAERRssPLLRRkD
K271-u	ssPLLRRkDGPVATA
T277	RkDGPVATALkkRPL
K280-u	GPVATALkkRPLDVT
K281-u	PVATALkkRPLDVTD
S297	ACSSAPGSGPSSPNS
S301	APGSGPSSPNSSSGN
S338	RLVTREGSVAPLPLY
S347	APLPLYTSPSLPNIT
S349	LPLYTSPSLPNITLG
S398	LTPYLSTSPLERDGA
T463-p	QHRPLGRtQsAPLPQ
S465-p	RPLGRtQsAPLPQNA
Y538	QALLDEPYLDRLPGQ
K546	LDRLPGQKEPSLAGV
K556	SLAGVQVKQEPIEsE
S562-p	VKQEPIEsEEEEAEA
S629-p	RPLSRAQsSPASATF
S630	PLSRAQsSPASATFP
S633	RAQsSPASATFPMSV
T635	QsSPASATFPMSVQE
S733	NRQKLDSSLTSVFVR
S736	KLDSSLTSVFVRLPC
S1017	EKVMDIHSKYWRCLQ
T1049	KEEAETVTAMASLSV
S1053	ETVTAMASLSVGVKP

	rat
S58	LRLDHQFSLPLEPAL
S167	GKESAVASTEVKMKL
K171	AVASTEVKMKLQEFV
S195	RNLNHCMSSDPRYWY
S209	YGKTQHSSLDQSSPP
S214	HSSLDQSSPPQSGVS
K235	VLGMYDAKDDFPLRK
S245	FPLRKTASEPNLKLR
S264	QKVAERRSSPLLRRK
S265	KVAERRSSPLLRRKD
K271	SSPLLRRKDGPVATA
T277	RKDGPVATALKKRPL
K280	GPVATALKKRPLDVT
K281	PVATALKKRPLDVTD
S297	ACSSAPGSGPSSPNS
S301	APGSGPSSPNSSSGN
S338	RLVTREGSVAPLPLY
S347	APLPLYTSPSLPNIT
S349	LPLYTSPSLPNITLG
S399	LTPYLSTSPLERDGG
T464	QHRPLGRTQSAPLPQ
S466	RPLGRTQSAPLPQNA
Y539	QALLDEPYLDRLPGQ
K547	LDRLPGQKEPSLAGV
K557	SLAGVQVKQEPIESE
S563	VKQEPIESEEEEVEA
S630	RPLSRAQSSPASATF
S631	PLSRAQSSPASATFP
S634	RAQSSPASATFPMSV
T636	QSSPASATFPMSVQE
S734	NRQKLDSSLTSVFVR
S737	KLDSSLTSVFVRLPC
S1018	EKVMGIHSEYWRCLQ
T1050	NEEAETVTAMASLSV
S1054	ETVTAMASLSVGVKP

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