a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; EC 184.108.40.206; Deacetylase; Hydrolase
Cellular Component: nucleoplasm; transcriptional repressor complex; cytoplasm; histone deacetylase complex; actomyosin; cytosol; neuromuscular junction; Z disc; nucleus; A band
Molecular Function: potassium ion binding; protein binding; transcription activator binding; NAD-dependent histone deacetylase activity (H3-K14 specific); zinc ion binding; sequence-specific DNA binding; histone deacetylase binding; protein deacetylase activity; chromatin binding; histone deacetylase activity; protein kinase binding; transcription factor binding; transcription corepressor activity
Biological Process: cardiac muscle hypertrophy; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; response to denervation involved in regulation of muscle adaptation; positive regulation of smooth muscle cell migration; regulation of gene expression, epigenetic; negative regulation of cell proliferation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; negative regulation of glycolysis; inflammatory response; skeletal development; response to drug; nervous system development; regulation of skeletal muscle fiber development; transcription, DNA-dependent; B cell activation; negative regulation of transcription factor activity; histone deacetylation; osteoblast development; chromatin remodeling; positive regulation of protein sumoylation; B cell differentiation; regulation of protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; negative regulation of transcription, DNA-dependent
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.