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Protein Page:
HDAC4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HDAC4 a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; Nuclear receptor co-regulator; Hydrolase; EC 3.5.1.98
Cellular Component: transcriptional repressor complex; histone deacetylase complex; cytoplasm; actomyosin; cytosol; neuromuscular junction; Z disc; nucleus; A band
Molecular Function: potassium ion binding; transcription activator binding; zinc ion binding; histone deacetylase binding; protein deacetylase activity; protein kinase binding; transcription factor binding; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity
Biological Process: cardiac muscle hypertrophy; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; response to denervation involved in regulation of muscle adaptation; negative regulation of cell proliferation; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; inflammatory response; negative regulation of glycolysis; skeletal development; response to drug; nervous system development; regulation of skeletal muscle fiber development; transcription, DNA-dependent; B cell activation; negative regulation of transcription factor activity; histone deacetylation; osteoblast development; chromatin remodeling; positive regulation of protein sumoylation; B cell differentiation; regulation of protein binding; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Reference #:  P56524 (UniProtKB)
Alt. Names/Synonyms: HA6116; HD4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288
Gene Symbols: HDAC4
Molecular weight: 119,040 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Crosstalk between PTMs  |  G1/S Checkpoint  |  NF-kB Signaling  |  Protein Acetylation  |  Wnt/├č-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HDAC4

Protein Structure Not Found.


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Sites Implicated In
cell motility, altered: S298‑p, S302‑p
transcription, altered: S210‑p, S246‑p, S467‑p, S632‑p
intracellular localization: S246‑p, S298‑p, S302‑p, S467‑p, S632‑p
molecular association, regulation: S246‑p, S467‑p, S632‑p
protein degradation: S298‑p, S302‑p
ubiquitination: S298‑p, S302‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S58-p LRLDHQFsLPVAEPA
0 1 S168-p GKESAVAsTEVKMKL
0 1 K172 AVAsTEVKMKLQEFV
0 1 S196 RNLNHCISSDPRYWY
1 2 S210-p YGKTQHSsLDQSSPP
0 1 S215 HSsLDQSSPPQSGVS
0 1 Y225-p QSGVSTSyNHPVLGM
0 1 Y233-p NHPVLGMyDAkDDFP
0 1 K236-ac VLGMyDAkDDFPLRK
6 28 S246-p FPLRKTAsEPNLKLR
2 8 S265-p QKVAERRssPLLRRK
2 10 S266-p KVAERRssPLLRRKD
0 1 K272 ssPLLRRKDGPVVtA
0 1 T278-p RKDGPVVtALKKRPL
0 1 K281 GPVVtALKKRPLDVT
0 1 K282 PVVtALKKRPLDVTD
2 0 S298-p ACSSAPGsGPSsPNN
1 0 S302-p APGsGPSsPNNSSGS
0 1 S339-p RLVAREGsAAPLPLY
0 1 S348-p APLPLYTsPsLPNIT
1 3 S350-p LPLYTsPsLPNITLG
0 1 T391-p RLSLFPGtHLtPYLS
0 1 T394-p LFPGtHLtPYLSTsP
0 2 S400-p LtPYLSTsPLERDGG
0 2 T465-p QHRPLGRtQsAPLPQ
4 25 S467-p RPLGRtQsAPLPQNA
0 1 Y540-p QALLDEPyLDRLPGQ
0 1 K548-ac LDRLPGQkEAHAQAG
1 0 K559-sm AQAGVQVkQEPIEsD
0 66 S565-p VkQEPIEsDEEEAEP
5 90 S632-p RPLSRAQssPAsAtF
0 12 S633-p PLSRAQssPAsAtFP
0 6 S636-p RAQssPAsAtFPVSV
0 1 T638-p QssPAsAtFPVSVQE
0 1 T648-p VSVQEPPtKPRFTTG
1 0 T707 CIRGRKATLEELQTV
0 1 S741-p DSKKLLGsLAsVFVR
0 1 S744-p KLLGsLAsVFVRLPC
0 1 S1025-p EKVMEIHsKYWRCLQ
0 1 T1057-p NEEAETVtAMAsLSV
0 1 S1061-p ETVtAMAsLSVGVKP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  mouse

 
S58 LRLDHQFSLPLEPAL
S167 GKESAVASTEVkMKL
K171-ac AVASTEVkMKLQEFV
S195-p RNLNHCIsSDPRYWY
S209-p YGKTQHSsLDQSsPP
S214-p HSsLDQSsPPQSGVS
Y224 QSGVSASYNHPVLGM
Y232 NHPVLGMYDAKDDFP
K235 VLGMYDAKDDFPLRK
S245-p FPLRKTAsEPNLKLR
S264-p QKVAERRssPLLRRk
S265-p KVAERRssPLLRRkD
K271-ub ssPLLRRkDGPVATA
T277 RkDGPVATALkkRPL
K280-ub GPVATALkkRPLDVT
K281-ub PVATALkkRPLDVTD
S297 ACSSAPGSGPSSPNS
S301 APGSGPSSPNSSSGN
S338 RLVTREGSVAPLPLY
S347 APLPLYTSPSLPNIT
S349 LPLYTSPSLPNITLG
T389 QRILFPGTHLTPYLS
T392 LFPGTHLTPYLSTSP
S398 LTPYLSTSPLERDGA
T463-p QHRPLGRtQsAPLPQ
S465-p RPLGRtQsAPLPQNA
Y538 QALLDEPYLDRLPGQ
K546 LDRLPGQKEPSLAGV
K556 SLAGVQVKQEPIEsE
S562-p VKQEPIEsEEEEAEA
S629-p RPLSRAQssPASATF
S630-p PLSRAQssPASATFP
S633 RAQssPASATFPMSV
T635 QssPASATFPMSVQE
T645 MSVQEPPTKPRFTTG
T704 CIRGRKATLEELQTV
S733 NRQKLDSSLTSVFVR
S736 KLDSSLTSVFVRLPC
S1017 EKVMDIHSKYWRCLQ
T1049 KEEAETVTAMASLSV
S1053 ETVTAMASLSVGVKP
3443 : Phospho-HDAC4 (Ser246)/HDAC5 (Ser259)/HDAC7 (Ser155) (D27B5) Rabbit mAb
3424 : Phospho-HDAC4 (Ser632)/HDAC5 (Ser498)/HDAC7 (Ser486) Antibody
  rat

 
S58 LRLDHQFSLPLEPAL
S167 GKESAVASTEVKMKL
K171 AVASTEVKMKLQEFV
S195 RNLNHCMSSDPRYWY
S209 YGKTQHSSLDQSSPP
S214 HSSLDQSSPPQSGVS
Y224 QSGVSASYNHPVLGM
Y232 NHPVLGMYDAKDDFP
K235 VLGMYDAKDDFPLRK
S245-p FPLRKTAsEPNLKLR
S264-p QKVAERRssPLLRRK
S265-p KVAERRssPLLRRKD
K271 ssPLLRRKDGPVATA
T277 RKDGPVATALKKRPL
K280 GPVATALKKRPLDVT
K281 PVATALKKRPLDVTD
S297 ACSSAPGSGPSSPNS
S301 APGSGPSSPNSSSGN
S338 RLVTREGSVAPLPLY
S347 APLPLYTSPSLPNIT
S349 LPLYTSPSLPNITLG
T390 RISLFPGTHLTPYLS
T393 LFPGTHLTPYLSTSP
S399 LTPYLSTSPLERDGG
T464 QHRPLGRTQsAPLPQ
S466-p RPLGRTQsAPLPQNA
Y539 QALLDEPYLDRLPGQ
K547 LDRLPGQKEPSLAGV
K557 SLAGVQVKQEPIEsE
S563-p VKQEPIEsEEEEVEA
S630-p RPLSRAQsSPASATF
S631 PLSRAQsSPASATFP
S634 RAQsSPASATFPMSV
T636 QsSPASATFPMSVQE
T646 MSVQEPPTKPRFTTG
T705-p CIRGRKAtLEELQTV
S734 NRQKLDSSLTSVFVR
S737 KLDSSLTSVFVRLPC
S1018 EKVMGIHSEYWRCLQ
T1050 NEEAETVTAMASLSV
S1054 ETVTAMASLSVGVKP
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