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H4 (human)

Overview H4 histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H4 is intronless. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Reference #:  P62805 (UniProtKB) Alt. Names/Synonyms: H4; H4 histone family, member A; H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4; HIST2H4A; HIST2H4B; HIST4H4; histone 1, H4a; histone cluster 1, H4a; Histone H4 Gene Symbols: HIST1H4A Molecular weight: 11,367 Da Basal Isoelectric point: 11.36  Predict pI for various phosphorylation states CST Pathways:  Histone Methylation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below H4 1KX4 - F/B=1-102 (human) 1KX5 - F/B=1-102 (human) 1M18 - F/B=1-102 (human) 1M19 - F/B=1-102 (human) 1M1A - F/B=1-102 (human) 1S32 - F/B=1-102 (human) 2CV5 - B/F=1-103 (human) 2LVM - B=15-28 (human) 2RNY - B=14-28 (human) 2RS9 - B=633-740 (human) 3A6N - F/B=1-103 (human) 3AFA - F/B=1-103 (human) 3AV1 - F/B=1-103 (human) 3AV2 - F/B=1-103 (human) 3AYW - F/B=1-103 (human) 3AZE - F/B=1-103 (human) 3AZF - F/B=1-103 (human) 3AZG - F/B=1-103 (human) 3AZH - F/B=1-103 (human) 3AZI - F/B=1-103 (human) 3AZJ - F/B=1-103 (human) 3AZK - F/B=1-103 (human) 3AZL - F/B=1-103 (human) 3AZM - F/B=1-103 (human) 3AZN - F/B=1-103 (human) 3CFS - E=28-42 (human) 3CFV - F/E=25-42 (human) 3F9W - H/F/G/E=16-25 (human) 3F9X - H/F/G/E=16-25 (human) 3F9Y - F/E=16-25 (human) 3F9Z - H/F/G/E=16-25 (human) 3NQJ - B=21-103 (human) 3NQU - B=1-103 (human) 3O36 - D/E=15-20 (human) 3QZS - D/C=13-22 (human) 3QZT - B=13-22 (human) 3QZV - C=8-18 (human) 3R45 - B=1-103 (human) 3UVW - B=2-12 (human) 3UVY - B=16-26 (human) 3UW9 - F/E=8-18 (human) 4GQB - A=1-637 (human) 4H9N - C=178-389 (human) 4H9O - C=178-389 (human) 4H9P - C=178-389 (human) 4H9Q - C=178-389 (human) 4H9R - C=178-389 (human) 4H9S - F/E=183-398 (human) 4HGA - C=1-103 (human) 1F66 - B/F=1-103 (mouse) 1U35 - B/F=1-103 (mouse) 2WP2 - Q/P=2-21 (mouse) 4DOW - D/C=15-26 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1KX4 1KX5 1M18 1M19 1M1A 1S32 2CV5 2LVM 2RNY 2RS9 3A6N 3AFA 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVY 3UW9 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA  |  Phospho3D  |  DISEASE 142750 602822  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell cycle regulation: K21‑m1 molecular association, regulation: K21‑m1

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	1		S2-p	______MsGrGkGGk
5	0		R4-m	____MsGrGkGGkGL
3	0		R4-m1	____MsGrGkGGkGL
6	0		R4-m2	____MsGrGkGGkGL
49	503		K6-a	__MsGrGkGGkGLGk
58	516		K9-a	sGrGkGGkGLGkGGA
59	521		K13-a	kGGkGLGkGGAkRHR
0	2		K13-m3	kGGkGLGkGGAkRHR
1	0		K13-s	kGGkGLGkGGAkRHR
0	2		K13-u	kGGkGLGkGGAkRHR
69	522		K17-a	GLGkGGAkRHRkVLR
0	3		K17-m3	GLGkGGAkRHRkVLR
1	0		H19	GkGGAkRHRkVLRDN
3	1		K21-a	GGAkRHRkVLRDNIQ
3	0		K21-m	GGAkRHRkVLRDNIQ
22	7		K21-m1	GGAkRHRkVLRDNIQ
21	5		K21-m2	GGAkRHRkVLRDNIQ
30	1		K21-m3	GGAkRHRkVLRDNIQ
0	1		R24	kRHRkVLRDNIQGIT
0	1		R24	kRHRkVLRDNIQGIT
0	6		K32-a	DNIQGITkPAIRRLA
0	1		K32-m1	DNIQGITkPAIRRLA
1	1		K32-m2	DNIQGITkPAIRRLA
0	129		K32-u	DNIQGITkPAIRRLA
0	1		R36	GITkPAIRRLARRGG
3	27		S48-p	RGGVKRIsGLIyEET
0	700		Y52-p	KRIsGLIyEETrGVL
1	0		R56-m	GLIyEETrGVLkVFL
1	0		R56-m2	GLIyEETrGVLkVFL
0	34		K60-a	EETrGVLkVFLENVI
0	1		K60-m1	EETrGVLkVFLENVI
0	1		K60-m2	EETrGVLkVFLENVI
0	1		K60-m3	EETrGVLkVFLENVI
0	63		K60-u	EETrGVLkVFLENVI
0	150		Y73-p	VIRDAVTytEHAkRk
0	18		T74-p	IRDAVTytEHAkRkt
1	0		H76	DAVTytEHAkRktVt
1	92		K78-a	VTytEHAkRktVtAM
1	0		K78-m	VTytEHAkRktVtAM
0	36		K78-u	VTytEHAkRktVtAM
0	3		K80-u	ytEHAkRktVtAMDV
1	5		T81-p	tEHAkRktVtAMDVV
0	3		T83-p	HAkRktVtAMDVVyA
0	1029		Y89-p	VtAMDVVyALkRQGR
2	238		K92-a	MDVVyALkRQGRTLY
1	16		K92-u	MDVVyALkRQGRTLY

	mouse
S2	______MSGrGkGGk
R4	____MSGRGkGGkGL
R4	____MSGRGkGGkGL
R4-m2	____MSGrGkGGkGL
K6-a	__MSGrGkGGkGLGk
K9-a	SGrGkGGkGLGkGGA
K13-a	kGGkGLGkGGAkRHR
K13	kGGkGLGKGGAkRHR
K13	kGGkGLGKGGAkRHR
K13	kGGkGLGKGGAkRHR
K17-a	GLGkGGAkRHRkVLr
K17-m3	GLGkGGAkRHRkVLr
H19	GkGGAkRHRkVLrDN
K21-a	GGAkRHRkVLrDNIQ
K21	GGAkRHRKVLrDNIQ
K21-m1	GGAkRHRkVLrDNIQ
K21-m2	GGAkRHRkVLrDNIQ
K21-m3	GGAkRHRkVLrDNIQ
R24-m1	kRHRkVLrDNIQGIT
R24-m2	kRHRkVLrDNIQGIT
K32-a	DNIQGITkPAIrRLA
K32	DNIQGITKPAIrRLA
K32	DNIQGITKPAIrRLA
K32-u	DNIQGITkPAIrRLA
R36-m1	GITkPAIrRLARRGG
S48-p	RGGVKRIsGLIyEET
Y52-p	KRIsGLIyEETRGVL
R56	GLIyEETRGVLkVFL
R56	GLIyEETRGVLkVFL
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60-u	EETRGVLkVFLENVI
Y73-p	VIRDAVTyTEHAkRK
T74	IRDAVTyTEHAkRKt
H76	DAVTyTEHAkRKtVT
K78-a	VTyTEHAkRKtVTAM
K78	VTyTEHAKRKtVTAM
K78-u	VTyTEHAkRKtVTAM
K80	yTEHAkRKtVTAMDV
T81-p	TEHAkRKtVTAMDVV
T83	HAkRKtVTAMDVVyA
Y89-p	VTAMDVVyALkRQGR
K92-a	MDVVyALkRQGRTLY
K92-u	MDVVyALkRQGRTLY

	rat
S2	______MSGRGkGGk
R4	____MSGRGkGGkGL
R4	____MSGRGkGGkGL
R4	____MSGRGkGGkGL
K6-a	__MSGRGkGGkGLGk
K9-a	SGRGkGGkGLGkGGA
K13-a	kGGkGLGkGGAkRHR
K13	kGGkGLGKGGAkRHR
K13	kGGkGLGKGGAkRHR
K13	kGGkGLGKGGAkRHR
K17-a	GLGkGGAkRHRKVLR
K17	GLGkGGAKRHRKVLR
H19	GkGGAkRHRKVLRDN
K21	GGAkRHRKVLRDNIQ
K21	GGAkRHRKVLRDNIQ
K21	GGAkRHRKVLRDNIQ
K21	GGAkRHRKVLRDNIQ
K21	GGAkRHRKVLRDNIQ
R24	kRHRKVLRDNIQGIT
R24	kRHRKVLRDNIQGIT
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
R36	GITKPAIRRLARRGG
S48-p	RGGVKRIsGLIyEET
Y52-p	KRIsGLIyEETRGVL
R56	GLIyEETRGVLKVFL
R56	GLIyEETRGVLKVFL
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
Y73	VIRDAVTYTEHAKRK
T74	IRDAVTYTEHAKRKT
H76	DAVTYTEHAKRKTVT
K78	VTYTEHAKRKTVTAM
K78	VTYTEHAKRKTVTAM
K78	VTYTEHAKRKTVTAM
K80	YTEHAKRKTVTAMDV
T81	TEHAKRKTVTAMDVV
T83	HAKRKTVTAMDVVyA
Y89-p	VTAMDVVyALKRQGR
K92	MDVVyALKRQGRTLY
K92	MDVVyALKRQGRTLY

	pig
S2	______MSGRGKGGk
R4	____MSGRGKGGkGL
R4	____MSGRGKGGkGL
R4	____MSGRGKGGkGL
K6	__MSGRGKGGkGLGK
K9-a	SGRGKGGkGLGKGGA
K13	KGGkGLGKGGAKRHR
K13	KGGkGLGKGGAKRHR
K13	KGGkGLGKGGAKRHR
K13	KGGkGLGKGGAKRHR
K17	GLGKGGAKRHRKVLR
K17	GLGKGGAKRHRKVLR
H19	GKGGAKRHRKVLRDN
K21	GGAKRHRKVLRDNIQ
K21	GGAKRHRKVLRDNIQ
K21	GGAKRHRKVLRDNIQ
K21	GGAKRHRKVLRDNIQ
K21	GGAKRHRKVLRDNIQ
R24	KRHRKVLRDNIQGIT
R24	KRHRKVLRDNIQGIT
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
R36	GITKPAIRRLARRGG
S48	RGGVKRISGLIYEET
Y52	KRISGLIYEETRGVL
R56	GLIYEETRGVLKVFL
R56	GLIYEETRGVLKVFL
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
Y73	VIRDAVTYTEHAKRK
T74	IRDAVTYTEHAKRKT
H76	DAVTYTEHAKRKTVT
K78	VTYTEHAKRKTVTAM
K78	VTYTEHAKRKTVTAM
K78	VTYTEHAKRKTVTAM
K80	YTEHAKRKTVTAMDV
T81	TEHAKRKTVTAMDVV
T83	HAKRKTVTAMDVVYA
Y89	VTAMDVVYALKRQGR
K92	MDVVYALKRQGRTLY
K92	MDVVYALKRQGRTLY

	cow
S2-p	______MsGRGkGGk
R4	____MsGRGkGGkGL
R4	____MsGRGkGGkGL
R4	____MsGRGkGGkGL
K6-a	__MsGRGkGGkGLGk
K9-a	sGRGkGGkGLGkGGA
K13-a	kGGkGLGkGGAkRhR
K13	kGGkGLGKGGAkRhR
K13	kGGkGLGKGGAkRhR
K13	kGGkGLGKGGAkRhR
K17-a	GLGkGGAkRhRKVLR
K17	GLGkGGAKRhRKVLR
H19-p	GkGGAkRhRKVLRDN
K21	GGAkRhRKVLRDNIQ
K21	GGAkRhRKVLRDNIQ
K21	GGAkRhRKVLRDNIQ
K21	GGAkRhRKVLRDNIQ
K21	GGAkRhRKVLRDNIQ
R24	kRhRKVLRDNIQGIT
R24	kRhRKVLRDNIQGIT
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
K32	DNIQGITKPAIRRLA
R36	GITKPAIRRLARRGG
S48-p	RGGVKRIsGLIYEET
Y52	KRIsGLIYEETRGVL
R56	GLIYEETRGVLKVFL
R56	GLIYEETRGVLKVFL
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
K60	EETRGVLKVFLENVI
Y73	VIRDAVTYTEhAKRK
T74	IRDAVTYTEhAKRKT
H76-p	DAVTYTEhAKRKTVT
K78	VTYTEhAKRKTVTAM
K78	VTYTEhAKRKTVTAM
K78	VTYTEhAKRKTVTAM
K80	YTEhAKRKTVTAMDV
T81	TEhAKRKTVTAMDVV
T83	hAKRKTVTAMDVVYA
Y89	VTAMDVVYALKRQGR
K92	MDVVYALKRQGRTLY
K92	MDVVYALKRQGRTLY

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