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H2B (human)

Overview H2B histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The gene encoding H2B is intronless. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleosome; nucleus Molecular Function: DNA binding; protein heterodimerization activity Biological Process: nucleosome assembly Reference #:  P33778 (UniProtKB) Alt. Names/Synonyms: H2B histone family, member F; H2B.1; H2B/f; H2B1B; H2BFF; HIST1H2BB; histone 1, H2bb; histone cluster 1, H2bb; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; MGC119804 Gene Symbols: HIST1H2BB Molecular weight: 13,950 Da Basal Isoelectric point: 10.31  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below H2B

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	Sites Implicated In
cell growth, induced: S33‑p translation, induced: S33‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
5	118		K6-a	__MPEPSkSAPAPkk
0	9		K6-u	__MPEPSkSAPAPkk
3	423		K12-a	SkSAPAPkkGskkAI
7	456		K13-a	kSAPAPkkGskkAIT
9	0		S15-p	APAPkkGskkAITkA
8	457		K16-a	PAPkkGskkAITkAQ
4	321		K17-a	APkkGskkAITkAQk
5	233		K21-a	GskkAITkAQkkDGK
0	71		K24-a	kAITkAQkkDGKKRK
1	8		K25-a	AITkAQkkDGKKRKR
7	0		S33-p	DGKKRKRsRkEsysI
0	4		K35-u	KKRKRsRkEsysIyV
6	40		S37-p	RKRsRkEsysIyVyk
0	9		Y38-p	KRsRkEsysIyVykV
1	7		S39-p	RsRkEsysIyVykVL
0	94		Y41-p	RkEsysIyVykVLkQ
0	132		Y43-p	EsysIyVykVLkQVH
0	2		K44-a	sysIyVykVLkQVHP
0	4		K44-u	sysIyVykVLkQVHP
1	3		K47-a	IyVykVLkQVHPDTG
1	0		K47-m	IyVykVLkQVHPDTG
0	1		K47-m2	IyVykVLkQVHPDTG
0	129		K47-u	IyVykVLkQVHPDTG
0	2		S57-p	HPDTGISskAMGIMN
0	4		K58-a	PDTGISskAMGIMNs
1	0		K58-m2	PDTGISskAMGIMNs
0	22		K58-u	PDTGISskAMGIMNs
0	38		S65-p	kAMGIMNsFVNDIFE
0	2		G76	DIFERIAGEASRLAH
0	68		Y84-p	EASRLAHyNkRstIt
0	17		K86-a	SRLAHyNkRstItSR
0	43		K86-u	SRLAHyNkRstItSR
0	7		S88-p	LAHyNkRstItSREI
0	3		T89-p	AHyNkRstItSREIQ
0	4		T91-p	yNkRstItSREIQTA
0	1		S92	NkRstItSREIQTAV
0	18		K109-a	LLPGELAkHAVsEGt
1	0		K109-m	LLPGELAkHAVsEGt
0	1		K109-m2	LLPGELAkHAVsEGt
0	130		K109-u	LLPGELAkHAVsEGt
0	4		S113-p	ELAkHAVsEGtkAVt
1	0		S113-g	ELAkHAVsEGtkAVt
0	2		T116-p	kHAVsEGtkAVtkYT
1	6		K117-a	HAVsEGtkAVtkYTS
0	134		K117-u	HAVsEGtkAVtkYTS
1	1		T120-p	sEGtkAVtkYTSSk_
1	14		K121-a	EGtkAVtkYTSSk__
8	145		K121-u	EGtkAVtkYTSSk__
0	13		K126-a	VtkYTSSk_______
1	1		K126-u	VtkYTSSk_______

	mouse
K6-a	__MPEPAkSAPAPkk
K6-u	__MPEPAkSAPAPkk
K12-a	AkSAPAPkkGskkAV
K13-a	kSAPAPkkGskkAVT
S15-p	APAPkkGskkAVTkA
K16-a	PAPkkGskkAVTkAQ
K17-a	APkkGskkAVTkAQk
K21-a	GskkAVTkAQkkDGK
K24-a	kAVTkAQkkDGKKRK
K25-a	AVTkAQkkDGKKRKR
S33-p	DGKKRKRsRkEsysV
K35-u	KKRKRsRkEsysVyV
S37-p	RKRsRkEsysVyVyk
Y38-p	KRsRkEsysVyVykV
S39-p	RsRkEsysVyVykVL
Y41-p	RkEsysVyVykVLkQ
Y43-p	EsysVyVykVLkQVH
K44-a	sysVyVykVLkQVHP
K44-u	sysVyVykVLkQVHP
K47-a	VyVykVLkQVHPDTG
K47	VyVykVLKQVHPDTG
K47	VyVykVLKQVHPDTG
K47-u	VyVykVLkQVHPDTG
S57-p	HPDTGISskAMGIMN
K58	PDTGISsKAMGIMNs
K58	PDTGISsKAMGIMNs
K58-u	PDTGISskAMGIMNs
S65-p	kAMGIMNsFVNDIFE
S76-p	DIFERIAsEASRLAH
Y84-p	EASRLAHyNkRstIT
K86-a	SRLAHyNkRstITsR
K86-u	SRLAHyNkRstITsR
S88-p	LAHyNkRstITsREI
T89-p	AHyNkRstITsREIQ
T91	yNkRstITsREIQTA
S92-p	NkRstITsREIQTAV
K109-a	LLPGELAkHAVsEGt
K109	LLPGELAKHAVsEGt
K109	LLPGELAKHAVsEGt
K109-u	LLPGELAkHAVsEGt
S113-p	ELAkHAVsEGtkAVt
S113	ELAkHAVSEGtkAVt
T116-p	kHAVsEGtkAVtkYT
K117	HAVsEGtKAVtkYTS
K117-u	HAVsEGtkAVtkYTS
T120-p	sEGtkAVtkYTSSk_
K121-a	EGtkAVtkYTSSk__
K121-u	EGtkAVtkYTSSk__
K126-a	VtkYTSSk_______
K126	VtkYTSSK_______

	rat
R6	__MPEPSRSTPAPkk
R6	__MPEPSRSTPAPkk
K12-a	SRSTPAPkkGskkAI
K13-a	RSTPAPkkGskkAIT
S15-p	TPAPkkGskkAITkA
K16-a	PAPkkGskkAITkAQ
K17-a	APkkGskkAITkAQK
K21-a	GskkAITkAQKKDGK
K24	kAITkAQKKDGKKRK
K25	AITkAQKKDGKKRKR
G33	DGKKRKRGRKESYSI
K35	KKRKRGRKESYSIYV
S37	RKRGRKESYSIYVYK
Y38	KRGRKESYSIYVYKV
S39	RGRKESYSIYVYKVL
Y41	RKESYSIYVYKVLkQ
Y43	ESYSIYVYKVLkQVH
K44	SYSIYVYKVLkQVHP
K44	SYSIYVYKVLkQVHP
K47	IYVYKVLKQVHPDTG
K47	IYVYKVLKQVHPDTG
K47	IYVYKVLKQVHPDTG
K47-u	IYVYKVLkQVHPDTG
S57	HPDTGISSKAMGIMN
K58	PDTGISSKAMGIMNS
K58	PDTGISSKAMGIMNS
K58	PDTGISSKAMGIMNS
S65	KAMGIMNSFVNDIFE
S76	DIFERIASEASRLAH
Y84	EASRLAHYNKRSTIT
K86	SRLAHYNKRSTITSR
K86	SRLAHYNKRSTITSR
S88	LAHYNKRSTITSREV
T89	AHYNKRSTITSREVQ
T91	YNKRSTITSREVQTA
S92	NKRSTITSREVQTAV
K109	LLPGELAKHAVSEGT
K109	LLPGELAKHAVSEGT
K109	LLPGELAKHAVSEGT
K109-u	LLPGELAkHAVSEGT
S113	ELAkHAVSEGTkAVT
S113	ELAkHAVSEGTkAVT
T116	kHAVSEGTkAVTkYT
K117	HAVSEGTKAVTkYTS
K117-u	HAVSEGTkAVTkYTS
T120	SEGTkAVTkYTSSK_
K121	EGTkAVTKYTSSK__
K121-u	EGTkAVTkYTSSK__
K126	VTkYTSSK_______
K126	VTkYTSSK_______

	cow
K5	___PEPAKSAPAPKK
K5	___PEPAKSAPAPKK
K11	AKSAPAPKKGSKKAV
K12	KSAPAPKKGSKKAVT
S14	APAPKKGSKKAVTKA
K15	PAPKKGSKKAVTKAQ
K16	APKKGSKKAVTKAQK
K20	GSKKAVTKAQKKDGK
K23	KAVTKAQKKDGKKRK
K24	AVTKAQKKDGKKRKR
S32-p	DGKKRKRsRKEsYSV
K34	KKRKRsRKEsYSVYV
S36-p	RKRsRKEsYSVYVYK
Y37	KRsRKEsYSVYVYKV
S38	RsRKEsYSVYVYKVL
Y40	RKEsYSVYVYKVLKQ
Y42	EsYSVYVYKVLKQVH
K43	sYSVYVYKVLKQVHP
K43	sYSVYVYKVLKQVHP
K46	VYVYKVLKQVHPDTG
K46	VYVYKVLKQVHPDTG
K46	VYVYKVLKQVHPDTG
K46	VYVYKVLKQVHPDTG
S56	HPDTGISSKAMGIMN
K57	PDTGISSKAMGIMNS
K57	PDTGISSKAMGIMNS
K57	PDTGISSKAMGIMNS
S64	KAMGIMNSFVNDIFE
G75	DIFERIAGEASRLAH
Y83	EASRLAHYNKRSTIT
K85	SRLAHYNKRSTITSR
K85	SRLAHYNKRSTITSR
S87	LAHYNKRSTITSREI
T88	AHYNKRSTITSREIQ
T90	YNKRSTITSREIQTA
S91	NKRSTITSREIQTAV
K108	LLPGELAKHAVSEGT
K108	LLPGELAKHAVSEGT
K108	LLPGELAKHAVSEGT
K108	LLPGELAKHAVSEGT
S112	ELAKHAVSEGTKAVT
S112	ELAKHAVSEGTKAVT
T115	KHAVSEGTKAVTKYT
K116	HAVSEGTKAVTKYTS
K116	HAVSEGTKAVTKYTS
T119	SEGTKAVTKYTSSK_
K120	EGTKAVTKYTSSK__
K120	EGTKAVTKYTSSK__
K125	VTKYTSSK_______
K125	VTKYTSSK_______

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