SLX4 (human)

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Protein Page:

SLX4 (human)

p	Phosphorylation
a	Acetylation
m	Methylation
m1	Mono-methylation
m2	Di-methylation
m3	Tri-methylation
u	Ubiquitination
s	Sumoylation
n	Neddylation
g	O-GlcNAc
h	Palmitoylation
ad	Adenylylation
sn	S-Nitrosylation
ca	Caspase cleavage

Overview

SLX4 regulatory subunit of different structure-specific endonucleases. Required for DNA recombination and repair. Together with SLX1 forms a Holliday junction (HJ) resolvase. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating HJs. Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. Required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks. Involved in Rad1/Rad10pdependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing. Interacts with MSH2; component of the MSH2-MSH3 mismatch repair complex. Interacts with TERF2-TERF2IP. Interacts with PLK1 and C20ORF94. Localizes to sites of DNA damage. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.

Protein type: DNA repair; Deoxyribonuclease

Cellular Component: nuclear chromosome, telomeric region; nuclear chromatin

Molecular Function: protein binding; 5'-flap endonuclease activity; 3'-flap endonuclease activity; enzyme activator activity; crossover junction endodeoxyribonuclease activity

Biological Process: positive regulation of catalytic activity; nucleotide-excision repair; DNA repair; double-strand break repair via homologous recombination

Reference #: Q8IY92 (UniProtKB)

Alt. Names/Synonyms: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; BTBD12; KIAA1784; KIAA1987; MUS312; SLX4; Structure-specific endonuclease subunit SLX4

Gene Symbols: SLX4

Molecular weight: 200,012 Da

Basal Isoelectric point: 5.74 Predict pI for various phosphorylation states

Select Structure to View Below

	SLX4

Modification Sites and Domains

Show Modification Legend

Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend

Show Multiple Sequence Alignment

SS SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.		human

0	1	S71-p	KHGIKEVsGERKTQK
0	1	S173-p	QEPSPNLsREKTREN
0	1	T194	QPPPSCLTTAVPSPS
0	1	T195	PPPSCLTTAVPSPSK
0	1	S199	CLTTAVPSPSKPRTA
0	1	S201	TTAVPSPSKPRTAQL
0	13	S228-p	PERLRHAsEECSLEA
0	1	S287-p	GASAHDDsLEEKGLF
0	1	K341	PECPICGKPFLTLKS
0	1	S383-p	AQPEGSSsPPMFSFS
0	1	S467-p	RKKKPPVsPPLLLVQ
0	1	T478-p	LLVQDSEtTGRQIED
0	2	S499-p	SEEVELSstPPLPAS
0	1	T500-p	EEVELSstPPLPASR
0	1	T590-p	RSPALHGtPTAGCGS
0	1	S601-p	GCGSRGPsPSASQRE
0	1	S626	AREGLSASPWPGSGG
0	1	K835-u	EEAETLLkSKDHEED
0	1	S884-p	ADWLEGGsPVSGQLL
0	1	S956-p	PEEALGHsSCSSPSR
0	1	I994	FSSTQGEISEPSQIT
0	8	S998	QGEISEPSQITSEPE
0	7	S1044-p	LGPPQGGsPRGSHHT
0	1	T1065-p	TPRSRGGtSQVGsPT
0	4	S1070-p	GGtSQVGsPTLLsPA
0	1	L1073	SQVGsPTLLsPAVPS
0	3	S1075-p	VGsPTLLsPAVPSKQ
0	2	R1086	PSKQKRDRSILTLSK
0	1	R1104	HQKGKERRSVLECRN
0	4	F1117	RNKGVLMFPEKsPSI
0	8	S1121-p	VLMFPEKsPSIDLTQ
0	2	T1127	KsPSIDLTQSNPDHS
0	11	S1135-p	QSNPDHSsSRsQKSS
1	1	S1138-p	PDHSsSRsQKSSSKL
0	2	S1157-p	EVILLLDsDEELELE
0	1	K1169-u	ELEQTKMkSISSDPL
0	1	K1179-u	SSDPLEEkKALEIsP
0	6	S1185-p	EkKALEIsPRSCELF
0	1	S1206	ADQEPSQSPPRSEAV
0	1	S1264-p	VPATPLAsRSRDCSs
1	3	S1271-p	sRSRDCSsQtQISSL
0	1	T1273-p	SRDCSsQtQISSLRS
0	6	S1309-p	NEVAQKFsVIRPQtP
0	47	T1315-p	FsVIRPQtPPPQtPs
0	4	T1320-p	PQtPPPQtPssCLtP
0	2	S1322-p	tPPPQtPssCLtPVs
0	5	S1323-p	PPPQtPssCLtPVsP
0	1	T1326-p	QtPssCLtPVsPGts
0	35	S1329-p	ssCLtPVsPGtsDGR
0	7	T1332-p	LtPVsPGtsDGRRQG
0	5	S1333-p	tPVsPGtsDGRRQGH
0	2	S1342-p	GRRQGHRsPSRPHPG
0	2	S1344	RQGHRsPSRPHPGGH
0	2	S1452-p	RTGPLSTssPSRRMN
0	2	S1453-p	TGPLSTssPSRRMNE
0	1	S1455	PLSTssPSRRMNEAA
0	1	S1464	RMNEAADSRDCRsPG
0	6	S1469-p	ADSRDCRsPGLLDTT
0	1	T1475	RsPGLLDTTPIRGSC
0	1	T1476	sPGLLDTTPIRGSCT
0	1	K1551	TPKGANRKKNLPPKV
0	1	K1552	PKGANRKKNLPPKVP
0	1	S1608	YTHQTLDSDSEDESQ
0	1	S1610	HQTLDSDSEDESQSS
1	1	S1631-p	PHCQTLAsQTYKPSR
0	1	K1657-u	GPGAHRPkGPAKTKG
1	1	S1716-p	GSDSSLSsQSSSSCE

	mouse

-	gap
-	gap
T20-p	PLPSCFTttGVPsPs
T21-p	LPSCFTttGVPsPsK
S25-p	FTttGVPsPsKPRVS
S27-p	ttGVPsPsKPRVSEL
S54-p	PERLRHAsEESPQKT
S111	EASSHHDSLEEKGLF
K165-u	PDCPICGkPFLTTKS
S207	AQPEVDGSPQVPSFS
C292	RKKRPPVCPPQLVTQ
T303	LVTQDSETTGRQIED
C324	SEEAELSCTPPLLAS
T325	EEAELSCTPPLLASK
S411	RPPASQSSLPVSHSP
L422	SHSPKIRLLSSSQRE
S447-p	AVEGLSSsPQPGSRG
K649	EEVETLLKPELCEEE
G698	TNPHGEDGAVSEPSL
-	gap
S801	LPSNPRVSSELsQIT
S805-p	PRVSSELsQITVDHE
S845	SQSSVDGSPSQSWLH
I870	VSQSHSSISRVAsPR
S875-p	SSISRVAsPRsLsPT
S878-p	SRVAsPRsLsPTTPT
S880-p	VAsPRsLsPTTPTKQ
S891-p	PTKQRRGsNIVTLRK
S909-p	HHRGQQSsPIAGHRN
S922-p	RNRGILIsPAKsPPI
S926-p	ILIsPAKsPPIDLtQ
T932-p	KsPPIDLtQSVPEPL
S940-p	QSVPEPLsPRAQDPL
A943	PEPLsPRAQDPLHFV
S962-p	EVILLLDsDEELEHT
E972	ELEHTKTESVSKDSP
K983	KDSPEGRKVPEFsPR
S988-p	GRKVPEFsPRSSELF
S1009-p	EDHEHFQsPLKREAG
S1066	VPATPGVSRSRDCSS
S1073	SRSRDCSSQTQIKSL
T1075	SRDCSSQTQIKSLKT
S1111	LETAQQFSVIMPHTQ
T1117	FSVIMPHTQPITLGA
-	gap
-	gap
-	gap
-	gap
T1121	MPHTQPITLGAFDSG
A1124	TQPITLGAFDSGRQA
F1125	QPITLGAFDSGRQAY
S1134-p	SGRQAYRsPsHPYPR
S1136-p	RQAYRsPsHPYPRHH
S1237	RTGPLTTSsPsSQVL
S1238-p	TGPLTTSsPsSQVLE
S1240-p	PLTTSsPsSQVLEAL
S1249-p	QVLEALHsDDCHsPG
S1254-p	LHsDDCHsPGLGttP
T1259-p	CHsPGLGttPIRGSC
T1260-p	HsPGLGttPIRGSCG
K1325-a	TPKGANQkkNLPPKV
K1326-a	PKGANQkkNLPPKVP
S1382-p	YTHQTLEsDsEDEVQ
S1384-p	HQTLEsDsEDEVQSP
T1405	PCRQASTTETCNPSR
-	gap
S1447	GSDNSFSSKSSSAEF

	rat

-	gap
-	gap
T28	APNGDSTTTGMPSPS
T29	PNGDSTTTGMPSPSK
S33	STTTGMPSPSKPRAS
S35	TTGMPSPSKPRASEL
S62	PERLRHTSEESPLKT
S121	EASSRPDSLEEKGLF
K175	PDCPICGKQFLTAKS
S217	AQPEAGSSPQVPSFS
C303	RRKRPPVCPPQLVTQ
T314	LVTQDSETTSRQIED
C335	SEETELACTPPLPAS
T336	EETELACTPPLPASK
-	gap
-	gap
S458	AVEGLSSSPCSRSAG
K659	EEAETLLKPEVCEED
S708	TNQHGEDSPVSEPSL
-	gap
S809-p	LPSNQRAsLELsQVT
S813-p	QRAsLELsQVTVGHE
S853	SQSSVGDSPSQSWLH
I876	PSVSQSHISKVVSPS
S881	SHISKVVSPSSPSPV
S884	SKVVSPSSPSPVTPA
S886	VVSPSSPSPVTPAKQ
S897	PAKQRRDSNILTLRK
S915	HHKGRQNSSKLGRRS
S928	RSRSILISPAKSPPI
S932	ILISPAKSPPIDLTQ
T938	KSPPIDLTQSVPEPL
S946	QSVPEPLSPRAQDPL
A949	PEPLSPRAQDPLRRV
S968	EVILLLDSDEEWELE
E980	ELEHIKTESVSKDSP
K990	SKDSPGGKIPEVSPR
S995	GGKIPEVSPRPSDLL
S1016	GDQEHFPSPPKREAG
S1073	VPATPGASKSRDRSS
S1080	SKSRDRSSQTQIRSL
T1082	SRDRSSQTQIRSLKI
S1113	LEAAQKFSVIMPHTQ
T1119	FSVIMPHTQPVTVGA
-	gap
-	gap
-	gap
-	gap
T1123	MPHTQPVTVGASDTR
A1126	TQPVTVGASDTRRQA
S1127	QPVTVGASDTRRQAY
S1136	TRRQAYRSPSRPYLR
S1138	RQAYRSPSRPYLRRH
S1241	RTGPLITSSPGSQVQ
S1242	TGPLITSSPGSQVQE
G1244	PLITSSPGSQVQEAL
S1253	QVQEALQSDGWHSPG
S1258	LQSDGWHSPGLGTTP
T1263	WHSPGLGTTPIRGSC
T1264	HSPGLGTTPIRGSCG
R1338	TPKGANQRKNLPPKV
K1339	PKGANQRKNLPPKVP
S1395	YTHQTLESDSEDEIQ
S1397	HQTLESDSEDEIQSS
T1418	ARSQASNTETCNPSR
-	gap
S1460	GSDNSFSSQSSSGEF

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