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Protein Page:
CABIN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CABIN1 an inhibitor of the calcium-dependent serine/threonine phosphatase, calcineurin. Inhibits calcineurin signaling in T cells, regulating T cell receptor (TCR) signaling, transcription, and apoptosis. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Represses myocyte enhancer factor 2 (MEF2)-mediated transcription by recruiting chromatin remodeling enzymes, and also negatively regulates the activity of the tumor suppressor p53. Is degraded in response to genotoxic stress, releasing its inhibition of p53, allowing p53 to elicit cellular stress responses. Involved in regulation of chromatin structure as part of the highly conserved HIRA/UBN1/CABIN1/ASF1A (HUCA) histone chaperone complex. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Protein phosphatase, regulatory subunit; Chaperone
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein phosphatase inhibitor activity
Biological Process: cell surface receptor linked signal transduction; negative regulation of catalytic activity; chromatin modification
Reference #:  Q9Y6J0 (UniProtKB)
Alt. Names/Synonyms: CABIN; CABIN1; CAIN; calcineurin binding protein 1; calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin-binding protein cabin-1; KIAA0330; PPP3IN
Gene Symbols: CABIN1
Molecular weight: 246,352 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CABIN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p RIAALNAsstIEDDH
0 1 S11-p IAALNAsstIEDDHE
0 1 T12-p AALNAsstIEDDHEG
0 1 S20-p IEDDHEGsFKSHKTQ
0 6 S66-p YHELLEAsLLREAVS
0 1 S433-p DPEEEDDsFNNyEVQ
0 2 Y437-p EDDsFNNyEVQSEAK
0 9 S450-p AKLESFPsIGPQRLS
0 1 S673-p LPNLHNDsVVSLEEI
0 4 S1439-p ERGKNEEsLEsTEGF
0 1 S1442-p KNEEsLEsTEGFRAA
0 1 K1577 GLFCERNKTNFFNGI
0 2 S1695-p TDVSHKAsPEDGQEG
0 1 G1702 sPEDGQEGLPQPKKP
0 2 T1811-p ISARQQPtPLtPAQP
0 14 T1814-p RQQPtPLtPAQPAPA
0 2 T1924-p QRQASGDtPttPKHP
0 1 T1926-p QASGDtPttPKHPKD
0 1 T1927-p ASGDtPttPKHPKDS
0 3 G2012 TPSMASLGPEGEELA
0 1 S2035-p PPQEPRHsPQVKMAP
0 3 T2089-p AQEAASEtQPLSsPP
0 2 S2094-p SEtQPLSsPPTAASS
0 2 S2139 MPKLVIPSAAtKFPP
0 1 T2142-p LVIPSAAtKFPPEIt
0 1 F2144 IPSAAtKFPPEItVt
0 3 T2149-p tKFPPEItVtPPtPt
0 16 T2151-p FPPEItVtPPtPtLL
0 14 T2154-p EItVtPPtPtLLsPK
0 6 T2156-p tVtPPtPtLLsPKGS
0 9 S2159-p PPtPtLLsPKGSISE
0 2 S2181-p SAILSAQsAANVRKE
  mouse

 
S10 RIAALNASSTIEDDH
S11 IAALNASSTIEDDHE
T12 AALNASSTIEDDHEG
S20 IEDDHEGSFKSHKIQ
R66 YHELLEARLLREAVS
P433 DPEEEDDPFNNYEVQ
Y437 EDDPFNNYEVQAEAK
N450 AKLESFSNVGPHRLS
S673 LPNLHNDSVVSLEEI
S1439-p ERGKTEEsLEsTEAF
S1442-p KTEEsLEsTEAFRVV
K1577-u GLFCERNkTNFFNGI
S1695-p TDVSHKAsPEDGQEs
S1702-p sPEDGQEsPQHPKKL
A1811 ISTRQQPAPLAPSPA
A1814 RQQPAPLAPSPAAPT
T1925 QRQASGDTPTTPKHP
T1927 QASGDTPTTPKHPKD
T1928 ASGDTPTTPKHPKDS
S2008-p TPSRAPLsPEGEEAS
S2031 LPQEPRYSHQIKMAA
- gap
- gap
S2106-p MPKLVIPsATTKsPP
T2109 LVIPsATTKsPPEIt
S2111-p IPsATTKsPPEItVt
T2116-p TKsPPEItVtPPtPt
T2118-p sPPEItVtPPtPtLL
T2121-p EItVtPPtPtLLsPK
T2123-p tVtPPtPtLLsPKGS
S2126-p PPtPtLLsPKGSISE
S2148 SAILSAQSAANVRKE
  rat

 
S10 RIAALNASSTIEDDH
S11 IAALNASSTIEDDHE
T12 AALNASSTIEDDHEG
S20 IEDDHEGSFKSHKIQ
R66 YHELLEARLLREAVS
P433 DPEEEDDPFNNYEVQ
Y437 EDDPFNNYEVQSEAK
N450 AKLESFSNVGPHRLS
S673 LPNLHNDSIVSLEEI
S1439-p ERGKTEEsLESTEAF
S1442 KTEEsLESTEAFRVV
K1577 GLFCERNKTNFFNGI
S1695 TDVSHKASPEDGQES
S1702 SPEDGQESLPHPKKL
A1811 ISTRQQPAPLVPSPV
V1814 RQQPAPLVPSPVTPT
A1924 QRQASGDAPTTPKHP
T1926 QASGDAPTTPKHPKD
T1927 ASGDAPTTPKHPKDS
S2003-p VPSRAPLsPDGEEVS
S2026 LSQEPRHSHQMKMAA
- gap
- gap
S2101 MPKLVIPSATTKFPP
T2104 LVIPSATTKFPPEIT
F2106 IPSATTKFPPEITVT
T2111 TKFPPEITVTPPTPT
T2113 FPPEITVTPPTPTLL
T2116 EITVTPPTPTLLSPK
T2118 TVTPPTPTLLSPKGS
S2121 PPTPTLLSPKGSISE
S2143 SAILSAQSAANVRKE
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