an inhibitor of the calcium-dependent serine/threonine phosphatase, calcineurin. Inhibits calcineurin signaling in T cells, regulating T cell receptor (TCR) signaling, transcription, and apoptosis. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Represses myocyte enhancer factor 2 (MEF2)-mediated transcription by recruiting chromatin remodeling enzymes, and also negatively regulates the activity of the tumor suppressor p53. Is degraded in response to genotoxic stress, releasing its inhibition of p53, allowing p53 to elicit cellular stress responses. Involved in regulation of chromatin structure as part of the highly conserved HIRA/UBN1/CABIN1/ASF1A (HUCA) histone chaperone complex. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit; Chaperone; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q11.23
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: protein phosphatase inhibitor activity
Biological Process: cell surface receptor linked signal transduction; DNA replication-independent nucleosome assembly; negative regulation of catalytic activity; chromatin modification
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.