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Protein Page:
CABIN1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CABIN1 an inhibitor of the calcium-dependent serine/threonine phosphatase, calcineurin. Inhibits calcineurin signaling in T cells, regulating T cell receptor (TCR) signaling, transcription, and apoptosis. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Represses myocyte enhancer factor 2 (MEF2)-mediated transcription by recruiting chromatin remodeling enzymes, and also negatively regulates the activity of the tumor suppressor p53. Is degraded in response to genotoxic stress, releasing its inhibition of p53, allowing p53 to elicit cellular stress responses. Involved in regulation of chromatin structure as part of the highly conserved HIRA/UBN1/CABIN1/ASF1A (HUCA) histone chaperone complex. Note: This description may include information from UniProtKB.
Protein type: Protein phosphatase, regulatory subunit; Transcription, coactivator/corepressor; Chaperone
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein phosphatase inhibitor activity
Biological Process: cell surface receptor linked signal transduction; DNA replication-independent nucleosome assembly; negative regulation of catalytic activity; chromatin modification
Reference #:  Q9Y6J0 (UniProtKB)
Alt. Names/Synonyms: CABIN; CABIN1; CAIN; calcineurin binding protein 1; calcineurin binding protein cabin 1; Calcineurin inhibitor; Calcineurin-binding protein cabin-1; KIAA0330; PPP3IN
Gene Symbols: CABIN1
Molecular weight: 246,352 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CABIN1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S10-p RIAALNAsstIEDDH
0 1 S11-p IAALNAsstIEDDHE
0 1 T12-p AALNAsstIEDDHEG
0 1 S20-p IEDDHEGsFKSHKTQ
0 7 S66-p YHELLEAsLLREAVS
0 3 S433-p DPEEEDDsFNNyEVQ
0 2 Y437-p EDDsFNNyEVQSEAK
0 9 S450-p AKLESFPsIGPQRLS
0 1 T480-p EFLLENLtNGGILEL
0 1 Y491-p ILELMMRyLKAMGHK
0 2 S673-p LPNLHNDsVVSLEEI
0 1 S802-p EQALSADsSGSILKV
0 1 S830-p LIQVIDCsMAVQEEA
0 1 Y948-p TALEQCFyCLySFPS
0 1 Y951-p EQCFyCLySFPSKKS
0 1 T1148-p SLWIEYGtMSYALHS
0 1 S1375 QATPDDRSQDSTAVA
0 1 S1388-p VALSDSSsTQDFFNE
0 1 S1398-p DFFNEPTsLLEGSRK
0 6 S1439-p ERGKNEEsLEsTEGF
0 1 S1442-p KNEEsLEsTEGFRAA
0 1 K1577 GLFCERNKTNFFNGI
0 1 S1605-p FAWHMNRsIVLLLKV
0 1 T1687 GLPGARMTTDVSHKA
0 3 S1695-p TDVSHKAsPEDGQEG
0 1 G1702 sPEDGQEGLPQPKKP
0 1 S1798-p ESRPTELsLEELsIS
0 1 S1803-p ELsLEELsISARQQP
0 2 T1811-p ISARQQPtPLtPAQP
0 15 T1814-p RQQPtPLtPAQPAPA
0 1 A1816 QPtPLtPAQPAPAPA
0 1 S1855-p KLLEDTEsGKTLLLD
0 1 Y1864-p KTLLLDAyRVWQQGQ
0 1 Y1876-p QGQKGVAyDLGRVER
0 2 T1924-p QRQASGDtPttPKHP
0 1 T1926-p QASGDtPttPKHPKD
0 1 T1927-p ASGDtPttPKHPKDs
0 1 S1934-p tPKHPKDsRENFFPV
0 4 G2012 TPSMASLGPEGEELA
0 1 S2035-p PPQEPRHsPQVKMAP
0 1 S2067-p TGAEPTCsQEGKLRP
0 2 T2089-p AQEAASEtQPLSsPP
0 4 S2094-p SEtQPLSsPPTAASS
0 2 S2139 MPKLVIPSAAtKFPP
0 1 T2142-p LVIPSAAtKFPPEIt
0 1 F2144 IPSAAtKFPPEItVt
0 3 T2149-p tKFPPEItVtPPtPt
0 16 T2151-p FPPEItVtPPtPtLL
0 14 T2154-p EItVtPPtPtLLsPK
0 6 T2156-p tVtPPtPtLLsPKGS
0 10 S2159-p PPtPtLLsPKGSIsE
0 1 S2165-p LsPKGSIsEETKQKL
0 2 S2181-p SAILSAQsAANVRKE
  mouse

 
S10 RIAALNASSTIEDDH
S11 IAALNASSTIEDDHE
T12 AALNASSTIEDDHEG
S20 IEDDHEGSFKSHKIQ
R66 YHELLEARLLREAVS
P433 DPEEEDDPFNNYEVQ
Y437 EDDPFNNYEVQAEAK
N450 AKLESFSNVGPHRLS
T480 AFLMENLTNGGLLEL
Y491 LLELMMRYLKSMGHK
S673 LPNLHNDSVVSLEEI
S802 EQALSSDSSGSILKE
S830 LIQVIDCSMAVQEEP
Y948 TALEQCFYCLYSFPS
Y951 EQCFYCLYSFPSKKS
T1148 SLWIEYGTMSYALHS
S1375-p QAAPDDRsQDSTAVA
S1388 VALSDSSSTQDFFNE
S1398 DFFNEPTSLLEGSRK
S1439-p ERGKTEEsLEsTEAF
S1442-p KTEEsLEsTEAFRVV
K1577-ub GLFCERNkTNFFNGI
S1605 FAWHMNRSIVLLLKV
T1687-p GLSGARMtTDVSHKA
S1695-p TDVSHKAsPEDGQEs
S1702-p sPEDGQEsPQHPKKL
S1798 ESRSAELSLEELSIS
S1803 ELSLEELSISTRQQP
A1811 ISTRQQPAPLAPsPA
A1814 RQQPAPLAPsPAAPT
S1816-p QPAPLAPsPAAPTTT
S1856 KLLEDTESGKTLLLD
Y1865 KTLLLDAYRVWQQGQ
Y1877 QGQKGMAYDLSRIEK
T1925 QRQASGDTPTTPKHP
T1927 QASGDTPTTPKHPKD
T1928 ASGDTPTTPKHPKDS
S1935 TPKHPKDSRENFFPA
S2008-p TPSRAPLsPEGEEAS
S2031 LPQEPRYSHQIKMAA
S2063 TGAEPTCSQASSTKV
- gap
- gap
S2106-p MPKLVIPsATTKsPP
T2109 LVIPsATTKsPPEIt
S2111-p IPsATTKsPPEItVt
T2116-p TKsPPEItVtPPtPt
T2118-p sPPEItVtPPtPtLL
T2121-p EItVtPPtPtLLsPK
T2123-p tVtPPtPtLLsPKGS
S2126-p PPtPtLLsPKGSISE
S2132 LsPKGSISEETKQKL
S2148 SAILSAQSAANVRKE
  rat

 
S10 RIAALNASSTIEDDH
S11 IAALNASSTIEDDHE
T12 AALNASSTIEDDHEG
S20 IEDDHEGSFKSHKIQ
R66 YHELLEARLLREAVS
P433 DPEEEDDPFNNYEVQ
Y437 EDDPFNNYEVQSEAK
N450 AKLESFSNVGPHRLS
T480 AFLMENLTNGGVLEL
Y491 VLELMMRYLKSMGHK
S673 LPNLHNDSIVSLEEI
S802 EQALSSDSRGSILKE
S830 LIQVIDCSMAVQEEP
Y948 TALEQCFYCLYSFPS
Y951 EQCFYCLYSFPSKKS
T1148 SLWIEYGTMSYALHS
S1375 QATPDDRSQDSTAVA
S1388 VALSDSSSTQDFFNE
S1398 DFFNEPTSLLDGSRK
S1439-p ERGKTEEsLESTEAF
S1442 KTEEsLESTEAFRVV
K1577 GLFCERNKTNFFNGI
S1605 FAWHMNRSIVLLLKV
T1687 GLSGARMTTDVSHKA
S1695 TDVSHKASPEDGQES
S1702 SPEDGQESLPHPKKL
S1798 ESRSAELSLEELSIS
S1803 ELSLEELSISTRQQP
A1811 ISTRQQPAPLVPSPV
V1814 RQQPAPLVPSPVTPT
S1816 QPAPLVPSPVTPTTA
S1855 KLLQDTESGKTLLLD
Y1864 KTLLLDAYRVWQQGQ
Y1876 QGQKAMAYDLSRIEK
A1924 QRQASGDAPTTPKHP
T1926 QASGDAPTTPKHPKD
T1927 ASGDAPTTPKHPKDS
S1934 TPKHPKDSRENFFPA
S2003-p VPSRAPLsPDGEEVS
S2026 LSQEPRHSHQMKMAA
S2058 TGAEPTFSQATSTKV
- gap
- gap
S2101 MPKLVIPSATTKFPP
T2104 LVIPSATTKFPPEIT
F2106 IPSATTKFPPEITVT
T2111 TKFPPEITVTPPTPT
T2113 FPPEITVTPPTPTLL
T2116 EITVTPPTPTLLSPK
T2118 TVTPPTPTLLSPKGS
S2121 PPTPTLLSPKGSISE
S2127 LSPKGSISEETKQKL
S2143 SAILSAQSAANVRKE
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