a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. Note: This description may include information from UniProtKB.
Molecular Function: protein C-terminus binding; glutamate receptor binding; Rho guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; guanyl-nucleotide exchange factor activity; receptor tyrosine kinase binding; protein kinase binding
Biological Process: regulation of Ras protein signal transduction; cell proliferation; regulation of Rac protein signal transduction; positive regulation of fibroblast proliferation; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; regulation of synaptic plasticity; positive regulation of Ras protein signal transduction; neurite development; positive regulation of GTPase activity; regulation of neuronal synaptic plasticity
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.