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RasGRF1 (mouse)

Overview RasGRF1 a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. Note: This description may include information from UniProtKB. Protein type: Guanine nucleotide exchange factor, Ras Cellular Component: growth cone; intracellular; cytosol Molecular Function: glutamate receptor binding; protein binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; phospholipid binding Biological Process: regulation of Ras protein signal transduction; regulation of Rac protein signal transduction; cell proliferation; positive regulation of Ras GTPase activity; regulation of small GTPase mediated signal transduction; activation of Rac GTPase; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; neurite development; regulation of neuronal synaptic plasticity Reference #:  P27671 (UniProtKB) Alt. Names/Synonyms: AI844718; Cdc25; CDC25Mm; GNRP; GRF beta; Grf1; Grfbeta; guanine nucleotide releasing factor 1; Guanine nucleotide-releasing protein; p190; P190-A; p190RhoGEF; Ras guanine release factor beta; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; Rasgrf1; RGRF1 Gene Symbols: Rasgrf1 Molecular weight: 144,102 Da Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  Regulation of Actin Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below RasGRF1 2IJE - S=1028-1262 (mouse)

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	Sites Implicated In
protein degradation: S737‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		S71	GLYLLEGSICKRAPS
0	1		S485-p	SSRGRLGsLSTKKEG
1	0		S581	QEKAAWTSDIIQCVD
1	0		S617	QMIKSDASLYCDDVD
0	1		S628	DDVDIRFSKTMNSCK
0	1		S697	MSAIPARSLELLFSS
0	1		S718-p	LYGDAPKsPRASRKF
0	2		S726-p	PRASRKFssPPPLAI
0	5		S727-p	RASRKFssPPPLAIG
0	2		T735-p	PPPLAIGtSsPSRRR
0	1		S736	PPLAIGtSsPSRRRK
1	3		S737-p	PLAIGtSsPSRRRKL
0	1		S739	AIGtSsPSRRRKLsL
1	4		S745-p	PSRRRKLsLNIPIIT
1	0		S766	LASLGCSSDSYANIH
0	1		Y769	LGCSSDSYANIHsPI
0	1		H773	SDSYANIHsPIsPFG
0	2		S774-p	DSYANIHsPIsPFGK
0	2		S777-p	ANIHsPIsPFGKTTL
1	0		G787	GKTTLDTGKLCMASS
1	0		S822-p	LSASRKHsSDVLKEE
0	2		S837-p	SEDDQNHsDEDNTEV
0	1		S845-p	DEDNTEVsPVKsPPt
0	1		S849-p	TEVsPVKsPPtPKSF
0	1		T852-p	sPVKsPPtPKSFLNR
1	0		N871	FPFFNYNNGILMTTC
3	0		S916-p	KEVFRRMsLANTGFS
0	1		F922	MsLANTGFSSDQRNI
0	1		K953-a	VLRHWVTkHTQDFDT
0	1		T995	AAANIIRTLTLEETT
0	1		T997	ANIIRTLTLEETTEQ
0	1		I1012	HSMLEEVILMTEGVK
0	1		S1079	TKHFNHVSNFIASEI
0	1		S1084	HVSNFIASEIIRNED
0	1		S1241	IQYLLDESFMLDEES

	human ► Hide Isoforms
C71	GLYLLEGCVCDRAPS
S481	ITRGRLGSLSLEKEG
S577	QEKAAWTSDISQCVD
S626	EMSRSDASLYCDDVD
S637	DDVDIRFSKTMNSCK
S709-p	IPARWLRsLELLFAS
S730-p	LYGEPPKsPRATRKF
S738-p	PRATRKFsSPPPLSI
S739	RATRKFsSPPPLSIT
T748	PPLSITKTSsPsRRR
S749	PLSITKTSsPsRRRK
S750-p	LSITKTSsPsRRRKL
S752-p	ITKTSsPsRRRKLIS
S759	sRRRKLISLNIPIIT
S781	AGSLSCNSNGyTSMy
Y784-p	LSCNSNGyTSMysAM
Y788-p	SNGyTSMysAMSPFS
S789-p	NGyTSMysAMSPFSK
S792	TSMysAMSPFSKATL
S802	SKATLDTSKLYVSSS
S835	PSALSKQSSEVSMRE
S851	SDIDQNQSDDGDTET
S859	DDGDTETSPTKSPTT
S863	TETSPTKSPTTPKSV
T866	SPTKSPTTPKSVKNK
N885	FPLFSYNNGVVMTSC
S929-p	KEKYRRMsLASAGFP
F935	MsLASAGFPPDQRNG
K966	VLRHWVSKHSQDFET
T1008	AAANIIRTLTQEDPG
T1010	ANIIRTLTQEDPGDN
T1025-p	QITLEEItQMAEGVK
S1092-p	TKHFNDIsNLIAsEI
S1097-p	DIsNLIAsEIIRNED
S1254-p	TQYLLDQsFVMDEES

	RasGRF1 iso3
C71	GLYLLEGCVCDRAPS
S481	ITRGRLGSLSLKKEG
S577	QEKAAWTSDISQCVD
S613	QMIKSDASLYCDDVD
S624-p	DDVDIRFsKTMNSCK
S693	ISAIPARSLELLFAS
S714	LYGEPPKSPRATRKF
S722	PRATRKFSSPPPLSI
S723	RATRKFSSPPPLSIT
T732	PPLSITKTSSPSRRR
S733	PLSITKTSSPSRRRK
S734	LSITKTSSPSRRRKL
S736	ITKTSSPSRRRKLsL
S742-p	PSRRRKLsLNIPIIT
S763	LAALSCNSNGYTSMY
Y766	LSCNSNGYTSMYSAM
Y770	SNGYTSMYSAMSPFS
S771	NGYTSMYSAMSPFSK
S774	TSMYSAMSPFSKATL
S784	SKATLDTSKLYVSSS
S817	PSALSKQSSEVSMRE
S833	SDIDQNQSDDGDTET
S841	DDGDTETSPTKSPTT
S845	TETSPTKSPTTPKSV
T848	SPTKSPTTPKSVKNK
N867	FPLFSYNNGVVMTSC
S911	KEKYRRMSLASAGFP
F917	MSLASAGFPPDQRNG
K948	VLRHWVSKHSQDFET
T990	AAANIIRTLTQEDPG
T992	ANIIRTLTQEDPGDN
T1007	QITLEEITQMAEGVK
S1074	TKHFNDISNLIASEI
S1079	DISNLIASEIIRNED
-	gap

	rat
S71-p	GLYLLEGsICKRMPS
S481	INKGRLGSLSLKKEG
S575-p	QEKAAWTsDIIQCVD
S611-p	QMIKSDAsLYCDDVD
S622	DDVDIRFSKTMNSCK
S691	ITAIPARSLELLFSS
S712	LYGDAPKSPRASRKF
S720	PRASRKFSsPPPLAI
S721-p	RASRKFSsPPPLAIG
T729-p	PPPLAIGtssPVRRR
S730-p	PPLAIGtssPVRRRK
S731-p	PLAIGtssPVRRRKL
V733	AIGtssPVRRRKLSL
S739	PVRRRKLSLNIPIIT
S760-p	LASLGCPsDGYTNIH
Y763	LGCPsDGYTNIHSPI
H767	sDGYTNIHSPISPFG
S768	DGYTNIHSPISPFGK
S771	TNIHSPISPFGKTTL
S781-p	GKTTLDTsKLCVASS
T811	SSGFRKPTSDILKEE
S824	EESDDDQSDVDDTEV
S832	DVDDTEVSPPTPKSF
-	gap
T835	DTEVSPPTPKSFRNR
S854-p	FPLFNYNsGIMMTCR
S898-p	KEIYRRMsLANTGyS
Y904-p	MsLANTGySSDQRNI
K935	VLRHWVTKHSQDFET
T977-p	AAANIMRtLtQEEIT
T979-p	ANIMRtLtQEEITEN
L994	HSMLDELLLMTEGVK
S1061	TRHFNHISNLIASEI
S1066	HISNLIASEILRNEE
T1223	TQYLVDETFVLDDES

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