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Protein Page:
RasGRF1 (mouse)

Overview
RasGRF1 a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, Ras
Cellular Component: growth cone; intracellular; cytosol
Molecular Function: protein binding; glutamate receptor binding; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity
Biological Process: regulation of Ras protein signal transduction; regulation of Rac protein signal transduction; cell proliferation; positive regulation of Ras GTPase activity; regulation of small GTPase mediated signal transduction; activation of Rac GTPase; small GTPase mediated signal transduction; regulation of Rho protein signal transduction; neurite development; regulation of neuronal synaptic plasticity
Reference #:  P27671 (UniProtKB)
Alt. Names/Synonyms: AI844718; Cdc25; CDC25Mm; GNRP; GRF beta; Grf1; Grfbeta; guanine nucleotide releasing factor 1; Guanine nucleotide-releasing protein; p190; P190-A; p190RhoGEF; Ras guanine release factor beta; RAS protein-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-specific nucleotide exchange factor CDC25; Rasgrf1; RGRF1
Gene Symbols: Rasgrf1
Molecular weight: 144,102 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

RasGRF1

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S737‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
1 0 S71 GLYLLEGSICKRAPS
0 1 S485-p SSRGRLGsLSTKKEG
1 0 S581 QEKAAWTSDIIQCVD
1 0 S617 QMIKSDASLYCDDVD
0 1 S718-p LYGDAPKsPRASRKF
0 2 S726-p PRASRKFssPPPLAI
0 5 S727-p RASRKFssPPPLAIG
0 2 T735-p PPPLAIGtSsPSRRR
0 1 S736 PPLAIGtSsPSRRRK
1 3 S737-p PLAIGtSsPSRRRKL
1 4 S745-p PSRRRKLsLNIPIIT
1 0 S766 LASLGCSSDSYANIH
0 1 Y769 LGCSSDSYANIHsPI
0 1 H773 SDSYANIHsPIsPFG
0 2 S774-p DSYANIHsPIsPFGK
0 2 S777-p ANIHsPIsPFGKTTL
1 0 G787 GKTTLDTGKLCMASS
1 0 S822-p LSASRKHsSDVLKEE
0 2 S837-p SEDDQNHsDEDNTEV
1 0 N871 FPFFNYNNGILMTTC
3 0 S916-p KEVFRRMsLANTGFS
3321 : Phospho-Ras-GRF1 (Ser916) Antibody
  human

► Hide Isoforms
 
C71 GLYLLEGCVCDRAPS
S481 ITRGRLGSLSLEKEG
S577 QEKAAWTSDISQCVD
S626 EMSRSDASLYCDDVD
S730 LYGEPPKSPRATRKF
S738-p PRATRKFsSPPPLSI
S739 RATRKFsSPPPLSIT
T748 PPLSITKTSsPSRRR
S749 PLSITKTSsPSRRRK
S750-p LSITKTSsPSRRRKL
S759 SRRRKLISLNIPIIT
S781 AGSLSCNSNGYTSMY
Y784 LSCNSNGYTSMYsAM
Y788 SNGYTSMYsAMSPFS
S789-p NGYTSMYsAMSPFSK
S792 TSMYsAMSPFSKATL
S802 SKATLDTSKLYVSSS
S835 PSALSKQSSEVSMRE
S851 SDIDQNQSDDGDTET
N885 FPLFSYNNGVVMTSC
S929-p KEKYRRMsLASAGFP
  RasGRF1 iso3  
C71 GLYLLEGCVCDRAPS
S481 ITRGRLGSLSLKKEG
S577 QEKAAWTSDISQCVD
S613 QMIKSDASLYCDDVD
S714 LYGEPPKSPRATRKF
S722 PRATRKFSSPPPLSI
S723 RATRKFSSPPPLSIT
T732 PPLSITKTSSPSRRR
S733 PLSITKTSSPSRRRK
S734 LSITKTSSPSRRRKL
S742-p PSRRRKLsLNIPIIT
S763 LAALSCNSNGyTSMy
Y766-p LSCNSNGyTSMySAM
Y770-p SNGyTSMySAMSPFS
S771 NGyTSMySAMSPFSK
S774 TSMySAMSPFSKATL
S784 SKATLDTSKLYVSSS
S817 PSALSKQSSEVSMRE
S833 SDIDQNQSDDGDTET
N867 FPLFSYNNGVVMTSC
S911 KEKYRRMSLASAGFP
  rat

 
S71-p GLYLLEGsICKRMPS
S481 INKGRLGSLSLKKEG
S575-p QEKAAWTsDIIQCVD
S611-p QMIKSDAsLYCDDVD
S712 LYGDAPKSPRASRKF
S720 PRASRKFSsPPPLAI
S721-p RASRKFSsPPPLAIG
T729-p PPPLAIGtssPVRRR
S730-p PPLAIGtssPVRRRK
S731-p PLAIGtssPVRRRKL
S739 PVRRRKLSLNIPIIT
S760-p LASLGCPsDGYTNIH
Y763 LGCPsDGYTNIHSPI
H767 sDGYTNIHSPISPFG
S768 DGYTNIHSPISPFGK
S771 TNIHSPISPFGKTTL
S781-p GKTTLDTsKLCVASS
T811 SSGFRKPTSDILKEE
S824 EESDDDQSDVDDTEV
S854-p FPLFNYNsGIMMTCR
S898-p KEIYRRMsLANTGYS
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