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Protein Page:
PRX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PRX Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition. Defects in PRX are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the periaxin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding
Biological Process: cell death; axon ensheathment
Reference #:  Q9BXM0 (UniProtKB)
Alt. Names/Synonyms: CMT4F; KIAA1620; Periaxin; PRAX; PRX
Gene Symbols: PRX
Molecular weight: 154,905 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below

PRX

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S7 _MEARSRSAEELRRA
0 1 T102-p CLKRTVPtGDLALRP
0 1 T111-p DLALRPGtVsGYEIK
0 1 S113-p ALRPGtVsGYEIKGP
0 1 P142 VKKKKMVPGALGVPA
0 1 S381 EAKVAKVSPEARVKG
0 1 G798 QAEGMEFGFKMPKMt
0 2 T805-p GFKMPKMtMPKLGRA
0 8 S900-p EVGFRVPsVEIVTPQ
0 1 S965-p KVSKFAIsLPKARVG
0 1 T1033 FGVRGRDTEAAELVP
0 1 S1065 MPKLKMPSFGLARGK
0 2 S1082 EVQGDRASPGEKAES
0 3 S1119-p AEGAVAVsGMQLSGL
0 1 S1328-p EEGEKAKsPKLRLPR
0 1 T1345 FSQSEMVTGEGSPSP
0 1 S1349 EMVTGEGSPSPEEEE
0 1 S1351 VTGEGSPSPEEEEEE
0 1 S1363 EEEEEEGSGEGASGR
0 1 K1400 QEGDAAPKsPVREKs
0 3 S1401-p EGDAAPKsPVREKsP
0 1 K1406 PKsPVREKsPKFRFP
0 4 S1407-p KsPVREKsPKFRFPR
0 53 S1439-p GLRVRLPsVGFSEtG
0 1 T1445-p PsVGFSEtGAPGPAR
  PRX iso2  
S7 _MEARSRSAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEIK
S113 ALRPGTVSGYEIKGP
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S7-p _MEARSRsAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEMK
S113 ALRPGTVSGYEMKGP
T142-p VKKKKMVtGALGTPA
S381-p EAKVVKGsPEAKAKG
S750-p QAKGTEFsFKLPKMT
T757 sFKLPKMTMPKLGKV
S848-p EVGFRVPsVEIVTPQ
S913 KVSKFTISLPKARAG
S979-p FGVKGRDsEADVLVA
S1011-p MPKLKMPsFGLSRGK
S1028-p ETQDGRVsPGEKLEA
S1060 QETEKVTSGVKPSGL
S1262 EVGEKVKSPKLRLPR
S1279-p FSQSESVsGEGsPsP
S1283-p ESVsGEGsPsPEEEE
S1285-p VsGEGsPsPEEEEEG
S1293-p PEEEEEGsGEGASSR
K1330 QEGDATSKsPVGEKs
S1331-p EGDATSKsPVGEKsP
K1336 SKsPVGEKsPKFRFP
S1337-p KsPVGEKsPKFRFPR
S1369-p GFRVRLPsVGFSETA
T1375 PsVGFSETAVPGSTR
  rat

 
S7-p _MEARSRsAEELRRA
T102 CLKRTVPTGDLALRP
T111 DLALRPGTVSGYEMK
S113 ALRPGTVSGYEMKGP
I142 VKKKKMVIGTLGTPA
S381 EAKVVKGSPEAKAKG
S740 QAEKTEFSFKLPKMT
T747 SFKLPKMTVPKLGKV
S838-p EAGFRVPsVEIVNPQ
S903 KVSKFAISLPRARAG
S971 FGAKGRDSEADVLVA
S1003 MPKLKMPSFGLSRGK
S1020-p EIQDGRVsPGEKLEA
S1052 QETEKVTSGVKPSGL
S1254 ETGEKVKSPKLRLPR
S1271 FSQSESASGEGSPSP
S1275 ESASGEGSPSPEEEE
S1277 ASGEGSPSPEEEEEG
S1285 PEEEEEGSGEGASGR
K1322-ub QEGDAASksPVGEks
S1323-p EGDAASksPVGEksP
K1328-ub SksPVGEksPKFRFP
S1329-p ksPVGEksPKFRFPR
S1361-p GFRVRLPsVGFSETA
T1367 PsVGFSETAAPGSAR
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