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Protein Page:
PRX (human)

Overview
PRX Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition. Defects in PRX are a cause of Dejerine-Sottas syndrome (DSS); also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie- Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome. Belongs to the periaxin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Cellular Component: cytoplasm; plasma membrane; nucleus
Molecular Function: protein binding
Biological Process: cell death; axon ensheathment
Reference #:  Q9BXM0 (UniProtKB)
Alt. Names/Synonyms: CMT4F; KIAA1620; Periaxin; PRAX; PRX
Gene Symbols: PRX
Molecular weight: 154,905 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
Select Structure to View Below

PRX

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S7 _MEARSRSAEELRRA
0 1 S381 EAKVAKVSPEARVKG
0 1 G798 QAEGMEFGFKMPKMt
0 1 T805-p GFKMPKMtMPKLGRA
0 8 S900-p EVGFRVPsVEIVTPQ
0 1 T1033 FGVRGRDTEAAELVP
0 1 S1065 MPKLKMPSFGLARGK
0 2 S1082 EVQGDRASPGEKAES
0 3 S1119-p AEGAVAVsGMQLSGL
0 1 T1345 FSQSEMVTGEGSPSP
0 1 S1349 EMVTGEGSPSPEEEE
0 1 S1351 VTGEGSPSPEEEEEE
0 1 S1363 EEEEEEGSGEGASGR
0 3 S1401-p EGDAAPKsPVREKsP
0 4 S1407-p KsPVREKsPKFRFPR
0 53 S1439-p GLRVRLPsVGFSETG
  PRX iso2  
S7 _MEARSRSAEELRRA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
S7-p _MEARSRsAEELRRA
S381-p EAKVVKGsPEAKAKG
S750-p QAKGTEFsFKLPKMT
T757 sFKLPKMTMPKLGKV
S848-p EVGFRVPsVEIVTPQ
S979-p FGVKGRDsEADVLVA
S1011-p MPKLKMPsFGLSRGK
S1028-p ETQDGRVsPGEKLEA
S1060 QETEKVTSGVKPSGL
S1279-p FSQSESVsGEGsPsP
S1283-p ESVsGEGsPsPEEEE
S1285-p VsGEGsPsPEEEEEG
S1293-p PEEEEEGsGEGASSR
S1331-p EGDATSKsPVGEKsP
S1337-p KsPVGEKsPKFRFPR
S1369-p GFRVRLPsVGFSETA
  rat

 
S7 _MEARSRSAEELRRA
S381 EAKVVKGSPEAKAKG
S740 QAEKTEFSFKLPKMT
T747 SFKLPKMTVPKLGKV
S838 EAGFRVPSVEIVNPQ
S971 FGAKGRDSEADVLVA
S1003 MPKLKMPSFGLSRGK
S1020 EIQDGRVSPGEKLEA
S1052 QETEKVTSGVKPSGL
S1271 FSQSESASGEGSPSP
S1275 ESASGEGSPSPEEEE
S1277 ASGEGSPSPEEEEEG
S1285 PEEEEEGSGEGASGR
S1323 EGDAASKSPVGEKSP
S1329 KSPVGEKSPKFRFPR
S1361 GFRVRLPSVGFSETA
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