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Protein Page:
FANCA (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FANCA DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Defects in FANCA are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Biological Process: male gonad development; protein complex assembly; DNA repair; male meiosis; female gonad development; regulation of cell proliferation
Reference #:  O15360 (UniProtKB)
Alt. Names/Synonyms: FA; FA-H; FA1; FAA; FACA; FAH; FANCA; FANCH; Fanconi anemia group A protein; Fanconi anemia, complementation group A; Fanconi anemia, complementation group H; Fanconi anemia, type 1; MGC75158; Protein FACA
Gene Symbols: FANCA
Molecular weight: 162,775 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below

FANCA

Protein Structure Not Found.


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Sites Implicated In
chromatin organization, altered: S1449‑p
molecular association, regulation: S1149‑p, S1449‑p
ubiquitination: S1449‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K44 PERAQKLKESAVRLL
0 1 K44-ub PERAQKLkESAVRLL
0 1 S46 RAQKLkESAVRLLRS
0 1 - under review  
0 1 - under review  
0 1 K249-ub FVLRGFQkNSDLRRT
0 1 K261-ub RRTVEPEkMPQVTVD
0 1 S303-p RCWFGVFsGHTLGsV
0 1 S309-p FsGHTLGsVISTDPL
0 1 T323-p LKRFFSHtLTQILtH
0 1 T329-p HtLTQILtHSPVLkA
0 1 K335-ub LtHSPVLkAsDAVQM
0 1 S337-p HSPVLkAsDAVQMQR
1 1 T351-p REWSFARtHPLLTsL
0 1 S357-p RtHPLLTsLYRRLFV
0 1 S421-p LMAQAFEsCQLDSMV
0 1 S458-p WFKASFGsTRGYHGC
0 1 Y488-p VPFESPRyLQVHILH
0 2 K515-ub TDYISLAkTRLADLk
0 1 K522-ub kTRLADLkVSIENMG
0 1 S536 GLYEDLSSAGDITEP
0 1 K608-ub VAFIESLkRADKIPP
0 1 R683-m2 QVAVISErLRAVLGH
0 1 K701-ub DSSVEISkIQLSINT
0 1 M1077 QRQRELLMYKRILLR
1 0 S1149-p CLRSRDPsLMVDFIL
0 2 K1199-ub PLPRELQkLQEGRQF
0 1 S1208-p QEGRQFAsDFLSPEA
0 1 S1301-p CLEKRKIsWLALFQL
0 1 T1309-p WLALFQLtESDLRLG
0 1 K1387-ub AGRSLELkGQGNPVE
0 1 K1398-ub NPVELITkARLFLLQ
1 25 S1449-p AAPDADLsQEPHLF_
  mouse

 
K44-ac PEREQKLkDsALKLL
K44 PEREQKLKDsALKLL
S46-p REQKLkDsALKLLRY
S86-p DRDSADAsSDRSAsF
S92-p AsSDRSAsFIRSAFR
G246 LISRGFQGSSDPRRL
R258 RRLVEPERLPQVATD
S299 SGWIPIYSGHTCCGV
G305 YSGHTCCGVVTENSL
T319 LKSFFSHTLTQILTH
T325 HTLTQILTHKPVLKV
K331 LTHKPVLKVSDAIQM
S333 HKPVLKVSDAIQMQK
T347 KEWSFAKTHHLLTDL
D353 KTHHLLTDLHCRVLA
S417 LMARAFESYHLDSMV
S454 WFKESFGSSHGYHSC
Y484 VPWEAPRYMQVHIFH
K511 TDYISLAKTRLADLK
K518 KTRLADLKVSLENVG
S532-p GLYEDLSsPGDIAER
K604 VALIETLKRADKIPS
K680 QVAVVSEKLNAVLGH
K698 GGSLQRAKIQLSVLP
T1071-p RRQQELLtCKRLLLC
A1142 CLRSQDPALVANQTL
R1192 PLPRELRRLQEAREF
S1201 QEAREFASNFASASA
S1293 CLERRKVSWLVLFQL
T1301 WLVLFQLTEKDAKLG
- gap
K1382 SPVQLITKARVFLLQ
Y1433 ADPSFDLYQEPQLF_
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