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Gab1 (human)

Overview Gab1 Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold Cellular Component: cytosol Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity; phospholipid binding Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; epidermis development; fibroblast growth factor receptor signaling pathway; positive regulation of MAPKKK cascade; heart development; insulin receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; response to oxidative stress; regulation of cell migration; activation of JNK activity Reference #:  Q13480 (UniProtKB) Alt. Names/Synonyms: GAB1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1 Gene Symbols: GAB1 Molecular weight: 76,616 Da Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Gab1

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	Sites Implicated In
cell cycle regulation: Y627‑p, Y659‑p molecular association, regulation: Y242‑p, Y259‑p, Y317‑p, Y373‑p, Y447‑p, Y472‑p, Y589‑p, Y627‑p, Y659‑p phosphorylation: Y627‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		Y47-p	GDPDVLEyyKNDHAK
1	1		Y48-p	DPDVLEyyKNDHAKK
1	0		Y83-p	KKEFENSyIFDINTI
0	27		Y183-p	IQEDPQDyLLLINCQ
0	4		K205-u	RTHADSAkSTSSETD
0	4		K221-u	NDNVPSHkNPASSQS
2	264		Y242-p	FFQQQMIyDsPPSRA
0	2		S244-p	QQQMIyDsPPSRAPS
0	1		P250	DsPPSRAPSAsVDss
0	2		S251	sPPSRAPSAsVDssL
0	3		S253-p	PSRAPSAsVDssLyN
0	2		S256-p	APSAsVDssLyNLPR
0	3		S257-p	PSAsVDssLyNLPRS
1	472		Y259-p	AsVDssLyNLPRSys
0	1		Y265-p	LyNLPRSysHDVLPK
0	22		S266-p	yNLPRSysHDVLPKV
3	15		Y285-p	TEADGELyVFNTPSG
0	3		S304-p	ETQMRHVsIsyDIPP
0	8		S306-p	QMRHVsIsyDIPPtP
5	40		Y307-p	MRHVsIsyDIPPtPG
0	3		T312-p	IsyDIPPtPGNtyQI
0	45		T316-p	IPPtPGNtyQIPRTF
2	192		Y317-p	PPtPGNtyQIPRTFP
0	1		T322	NtyQIPRTFPEGTLG
0	1		S355-p	PHPAHDRsPVETCSI
0	3		T365-p	ETCSIPRtASDtDss
0	3		T369-p	IPRtASDtDssyCIP
0	5		S371-p	RtASDtDssyCIPTA
0	1		S372-p	tASDtDssyCIPTAG
4	281		Y373-p	ASDtDssyCIPTAGM
0	5		S381-p	CIPTAGMsPsRSNtI
0	1		S383-p	PTAGMsPsRSNtIST
1	1		T387-p	MsPsRSNtISTVDLN
0	3		S401-p	NKLRKDAssQDCyDI
0	2		S402-p	KLRKDAssQDCyDIP
3	1090		Y406-p	DAssQDCyDIPRAFP
0	1		S417	RAFPSDRSssLEGFH
0	2		S418-p	AFPSDRSssLEGFHN
0	4		S419-p	FPSDRSssLEGFHNH
0	2		F427	LEGFHNHFKVKNVLT
0	2		S439	VLTVGSVSSEELDEN
5	13		Y447-p	SEELDENyVPMNPNS
0	4		S454	yVPMNPNSPPRQHSS
6	2		Y472-p	EPIQEANyVPMtPGT
2	0		T476-p	EANyVPMtPGTFDFS
0	1		S499-p	PAHMGFRssPKtPPR
0	1		S500-p	AHMGFRssPKtPPRR
0	4		T503-p	GFRssPKtPPRRPVP
0	2		-	gap
1	1		S551-p	ELQAPVRsPITRSFA
1	0		S567	DSSRFPMSPRPDSVH
6	0		Y589-p	SHDSEENyVPMNPNL
15	422		Y627-p	KGDKQVEyLDLDLDs
0	3		S634-p	yLDLDLDsGKstPPR
0	5		K636	DLDLDsGKstPPRKQ
0	3		S637-p	LDLDsGKstPPRKQK
0	7		T638-p	DLDsGKstPPRKQKS
0	2		K642	GKstPPRKQKSSGSG
0	1		S648	RKQKSSGSGSSVADE
0	1		S651	KSSGSGSSVADERVD
6	1479		Y659-p	VADERVDyVVVDQQK
0	14		S683-p	AWTDGRQstESETPA
0	21		T684-p	WTDGRQstESETPAK
0	1		A690	stESETPAKSVK___

	Gab1 iso2
Y47	GDPDVLEYYKNDHAK
Y48	DPDVLEYYKNDHAKK
Y83	KKEFENSYIFDINTI
Y183	IQEDPQDYLLLINCQ
K205	RTHADSAKSTSSETD
K221	NDNVPSHKNPASSQS
Y242-p	FFQQQMIyDSPPSRA
S244	QQQMIyDSPPSRAPS
P250	DSPPSRAPSASVDSS
S251	SPPSRAPSASVDSSL
S253	PSRAPSASVDSSLyN
S256	APSASVDSSLyNLPR
S257	PSASVDSSLyNLPRS
Y259-p	ASVDSSLyNLPRSYS
Y265	LyNLPRSYSHDVLPK
S266	yNLPRSYSHDVLPKV
Y285	TEADGELYVFNTPSG
S304	ETQMRHVSISYDIPP
S306	QMRHVSISYDIPPTP
Y307	MRHVSISYDIPPTPG
T312	ISYDIPPTPGNTyQI
T316	IPPTPGNTyQIPRTF
Y317-p	PPTPGNTyQIPRTFP
T322	NTyQIPRTFPEGTLG
S355	PHPAHDRSPVETCSI
T365	ETCSIPRTASDTDSS
T369	IPRTASDTDSSyCIP
S371	RTASDTDSSyCIPTA
S372	TASDTDSSyCIPTAG
Y373-p	ASDTDSSyCIPTAGM
S381	CIPTAGMSPSRSNTI
S383	PTAGMSPSRSNTIST
T387	MSPSRSNTISTVDLN
S401	NKLRKDASSQDCyDI
S402	KLRKDASSQDCyDIP
Y406-p	DASSQDCyDIPRAFP
S417	RAFPSDRSSSLEGFH
S418	AFPSDRSSSLEGFHN
S419	FPSDRSSSLEGFHNH
F427	LEGFHNHFKVKNVLT
S439	VLTVGSVSSEELDEN
Y447	SEELDENYVPMNPNS
S454	YVPMNPNSPPRQHSS
Y472	EPIQEANYVPMTPGT
T476	EANYVPMTPGTFDFS
S499	PAHMGFRSSPKTPPR
S500	AHMGFRSSPKTPPRR
T503	GFRSSPKTPPRRPVP
S547-p	HGLERTDsQTIGDFA
S581	ELQAPVRSPITRSFA
S597	DSSRFPMSPRPDSVH
Y619	SHDSEENYVPMNPNL
Y657-p	KGDKQVEyLDLDLDS
S664	yLDLDLDSGKSTPPR
K666	DLDLDSGKSTPPRKQ
S667	LDLDSGKSTPPRKQK
T668	DLDSGKSTPPRKQKS
K672	GKSTPPRKQKSSGSG
S678	RKQKSSGSGSSVADE
S681	KSSGSGSSVADERVD
Y689-p	VADERVDyVVVDQQK
S713	AWTDGRQSTESETPA
T714	WTDGRQSTESETPAK
A720	STESETPAKSVK___

	mouse
Y47	GDPDVLEYYKNDHAK
Y48	DPDVLEYYKNDHAKK
Y83	KKEFENSYIFDINTI
Y183	LQDDPQDYLLLINCQ
K205-u	RTLFDSAkPTFSETD
Q221	NDNVPSHQTPASSQS
Y242-p	FFQQQMMyDCPPSRL
C244	QQQMMyDCPPSRLts
T250-p	DCPPSRLtsVsGESS
S251-p	CPPSRLtsVsGESSL
S253-p	PSRLtsVsGESSLyN
S256	LtsVsGESSLyNLPR
S257	tsVsGESSLyNLPRS
Y259-p	VsGESSLyNLPRSYs
Y265	LyNLPRSYsHDVLPK
S266-p	yNLPRSYsHDVLPKE
Y285-p	TEADGELyTFNTPSG
S304-p	ETQMRHVsIsyDIPP
S306-p	QMRHVsIsyDIPPtP
Y307-p	MRHVsIsyDIPPtPG
T312-p	IsyDIPPtPGNtyQI
T316-p	IPPtPGNtyQIPRtF
Y317-p	PPtPGNtyQIPRtFP
T322-g	NtyQIPRtFPESTLG
S355	PHPTHDRSPVETCGV
T365	ETCGVPRTASDtDSS
T369-p	VPRTASDtDSSyCIP
S371	RTASDtDSSyCIPPP
S372	TASDtDSSyCIPPPA
Y373-p	ASDtDSSyCIPPPAG
T382	IPPPAGMTPSRSNtI
S384	PPAGMTPSRSNtIST
T388-p	MTPSRSNtISTVDLN
S402	NKLRKDASSQDCyDI
S403	KLRKDASSQDCyDIP
Y407-p	DASSQDCyDIPRTFP
S418-p	RTFPSDRsssLEGFH
S419-p	TFPSDRsssLEGFHS
S420-p	FPSDRsssLEGFHSQ
Y428-p	LEGFHSQyKIKSVLT
S440-p	VLTAGGVsGEELDEN
Y448-p	GEELDENyVPMNPNs
S455-p	yVPMNPNsPPRQHSG
Y473-p	EPIQEPNyVPMtPGT
T477-p	EPNyVPMtPGTFDFS
S500-p	PAHMGFRssPKtPPR
S501-p	AHMGFRssPKtPPRR
T504-p	GFRssPKtPPRRPVP
-	gap
S552-p	ELQAPVRsPITRSFA
S568-p	DSSRFPMsPRPDSVH
Y590-p	SHDSEENyVPMNPNL
Y628-p	KGDKQVEyLDLDLDs
S635-p	yLDLDLDsGKStPPR
K637	DLDLDsGKStPPRKQ
S638	LDLDsGKStPPRKQK
T639-p	DLDsGKStPPRKQKS
K643	GKStPPRKQKSSGsG
S649-p	RKQKSSGsGSsMADE
S652-p	KSSGsGSsMADERVD
Y660-p	MADERVDyVVVDQQK
S684	AWTDGRQSTESETPt
T685	WTDGRQSTESETPtK
T691-p	STESETPtKNVK___

	rat
Y47	GDPDVLEYYKNDHAK
Y48	DPDVLEYYKNDHAKK
Y83	KKEFENSYIFDINTI
Y183-p	LREDPQDyLLLINCQ
K205	RAHFDSAKPTSSETD
K221	NDNVPSHKPPASSQG
Y242	FFQQQMVYDCPPPRV
C244	QQQMVYDCPPPRVTs
T250	DCPPPRVTsVSGEsG
S251-p	CPPPRVTsVSGEsGL
S253	PPRVTsVSGEsGLyN
S256-p	VTsVSGEsGLyNLPR
G257	TsVSGEsGLyNLPRS
Y259-p	VSGEsGLyNLPRSYs
Y265	LyNLPRSYsHDVLPK
S266-p	yNLPRSYsHDVLPKE
Y285	TEADGELYVFNTPSG
S304	EAQMRHVSISYDIPP
S306	QMRHVSISYDIPPTP
Y307	MRHVSISYDIPPTPG
T312	ISYDIPPTPGNTYQV
T316	IPPTPGNTYQVPRTF
Y317	PPTPGNTYQVPRTFP
T322	NTYQVPRTFPEGTLG
S355	PHSTHDRSPVETCGV
T365	ETCGVPRTASDTDSS
T369	VPRTASDTDSSYCIP
S371	RTASDTDSSYCIPPA
S372	TASDTDSSYCIPPAG
Y373	ASDTDSSYCIPPAGM
P381	CIPPAGMPPSRSNTI
S383	PPAGMPPSRSNTIST
T387	MPPSRSNTISTVDLN
G401	NKLRKDAGSQDCyDI
S402	KLRKDAGSQDCyDIP
Y406-p	DAGSQDCyDIPRTFP
S417	RTFPSDRSSSLEGFH
S418	TFPSDRSSSLEGFHN
S419	FPSDRSSSLEGFHNQ
L427	LEGFHNQLKIKNVLA
S439	VLAAGNVSGEELDEN
Y447	GEELDENYVPMNPNS
S454	YVPMNPNSPPRHHPS
Y472	EPIQEPNYVPMTPGT
T476	EPNYVPMTPGTFDFS
S499	PAHLGFRSSPKTPPR
S500	AHLGFRSSPKTPPRR
T503	GFRSSPKTPPRRPVP
-	gap
S551	ELQAPVRSPITRSFA
S567	DSSRFPMSPRPDSVH
Y589	SHDSEENYVPMNPNL
Y627-p	KGDKQVEyLDLDLES
S634	yLDLDLESGkSTPPR
K636-u	DLDLESGkSTPPRkQ
S637	LDLESGkSTPPRkQK
T638	DLESGkSTPPRkQKN
K642-u	GkSTPPRkQKNSGSG
S648	RkQKNSGSGSSMSDE
S651	KNSGSGSSMSDERVD
Y659-p	MSDERVDyVVVDQQK
S683	AWTDGRQSTESETPT
T684	WTDGRQSTESETPTK
T690	STESETPTKNVK___

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