a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Autophagy; DNA binding protein
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; DNA bending activity; transcription factor binding; protein kinase binding
Biological Process: tissue development; nerve growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; regulation of translation; regulation of transcription factor activity; response to stress; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; initiation of primordial ovarian follicle growth; positive regulation of erythrocyte differentiation; antral ovarian follicle growth; ovulation from ovarian follicle; pattern specification process; oocyte maturation; regulation of cell proliferation; embryonic development; induction of apoptosis; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.