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Protein Page:
FOXO3A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Autophagy; Transcription factor
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; chromatin DNA binding; protein kinase binding; transcription factor activity
Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; transcription, DNA-dependent; DNA damage response, signal transduction by p53 class mediator; initiation of primordial ovarian follicle growth; antral ovarian follicle growth; positive regulation of transcription, DNA-dependent; positive regulation of erythrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; ovulation from ovarian follicle; oocyte maturation; regulation of transcription from RNA polymerase II promoter; regulation of translation; positive regulation of neuron apoptosis; innate immune response; positive regulation of transcription from RNA polymerase II promoter
Reference #:  O43524 (UniProtKB)
Alt. Names/Synonyms: AF6q21; AF6q21 protein; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3; FOXO3A; MGC12739; MGC31925
Gene Symbols: FOXO3
Molecular weight: 71,277 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXO3A

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S253‑p
apoptosis, inhibited: S253‑p, S315‑p, S644‑p
cell cycle regulation: S7‑p, S253‑p, S315‑p, S644‑p
cell growth, altered: S294‑p, S344‑p, S425‑p
transcription, altered: T32‑p, S253‑p
transcription, induced: S626‑p
transcription, inhibited: S253‑p, S315‑p, S644‑p
activity, inhibited: T32‑p, S253‑p, S294‑p, S344‑p, S425‑p, S644‑p
intracellular localization: S7‑p, T32‑p, S209‑p, S253‑p, S315‑p, S644‑p
molecular association, regulation: T32‑p, S209‑p, S253‑p, S294‑p, S344‑p, S425‑p, S626‑p
phosphorylation: S253‑p
protein degradation: S294‑p, S344‑p, S425‑p, S644‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 29 S7-p _MAEAPAsPAPLsPL
1 24 S12-p PAsPAPLsPLEVELD
0 1 S26-p DPEFEPQsRPRsCtW
0 4 S30-p EPQsRPRsCtWPLQR
57 94 T32-p QsRPRsCtWPLQRPE
0 3 S43-p QRPELQAsPAKPSGE
0 1 S48 QAsPAKPSGETAADS
0 1 S55 SGETAADSMIPEEED
1 0 S90 GGSGTLGSGLLLEDS
0 1 S161-p RNAWGNLsyADLITR
0 1 Y162-p NAWGNLsyADLITRA
2 0 T179-p SSPDKRLtLSQIyEW
0 8 Y184-p RLtLSQIyEWMVRCV
4 0 S209-p SSAGWKNsIRHNLsL
1 1 S215-p NsIRHNLsLHSRFMR
1 0 S231-p QNEGTGKssWWIINP
1 0 S232-p NEGTGKssWWIINPD
2 0 K242-ac IINPDGGksGKAPRR
1 0 S243-p INPDGGksGKAPRRR
20 79 S253-p APRRRAVsMDNSNkY
2 0 K259-ac VsMDNSNkYTKSRGR
1 0 K271 RGRAAKKKAALQTAP
0 10 S280-p ALQTAPEsADDsPsQ
1 17 S284-p APEsADDsPsQLskW
0 3 S286-p EsADDsPsQLskWPG
0 2 S289-p DDsPsQLskWPGsPt
2 0 K290-ac DsPsQLskWPGsPts
4 68 S294-p QLskWPGsPtsRsSD
0 1 T296-p skWPGsPtsRsSDEL
0 2 S297-p kWPGsPtsRsSDELD
0 5 S299-p PGsPtsRsSDELDAW
1 2 S300 GsPtsRsSDELDAWt
0 1 T307-p SDELDAWtDFRsRTN
0 2 S311-p DAWtDFRsRTNsNAs
3 1 S315-p DFRsRTNsNAstVsG
7 1 S318-p sRTNsNAstVsGRLS
0 1 T319-p RTNsNAstVsGRLSP
7 0 S321-p NsNAstVsGRLSPIM
2 1 S344-p QDDDAPLsPMLYSSS
0 1 T395-p DDLLDNItLPPsQPS
2 0 S399-p DNItLPPsQPSPTGG
4 4 S413-p GLMQRSSsFPYTTKG
0 1 G420 sFPYTTKGsGLGsPt
0 4 S421-p FPYTTKGsGLGsPtS
4 4 S425-p TKGsGLGsPtSSFNS
1 3 T427-p GsGLGsPtSSFNSTV
0 1 S429 GLGsPtSSFNSTVFG
0 1 T433 PtSSFNSTVFGPSsL
0 1 S439-p STVFGPSsLNSLRQS
0 2 S551-p LGGSRALsNSVsNMG
2 0 S555-p RALsNSVsNMGLSES
2 0 K569-ac SSSLGSAkHQQQsPV
2 0 S574-p SAkHQQQsPVSQSMQ
2 0 S588-p QTLSDSLsGSSLYST
3 0 S626-p SLECDMEsIIRSELM
2 0 S644-p GLDFNFDsLISTQNV
2599 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
8174 : Phospho-FoxO3a (Ser413) (D77C9) Rabbit mAb
  mouse

 
S7-p _MAEAPAsPVPLsPL
S12-p PAsPVPLsPLEVELD
S26 DPEFEPQSRPRSCtW
S30 EPQSRPRSCtWPLQR
T32-p QSRPRSCtWPLQRPE
S43-p QRPELQAsPAKPsGE
S48-p QAsPAKPsGETAADs
S55-p sGETAADsMIPEEDD
S89-p GVSSTLGsGLLLEDS
S160 RNAWGNLSYADLITR
Y161 NAWGNLSYADLITRA
T178 SSPDKRLTLSQIYEW
Y183 RLTLSQIYEWMVRCV
S208-p SSAGWKNsIRHNLSL
S214 NsIRHNLSLHSRFMR
S230 QNEGTGKSSWWIINP
S231 NEGTGKSSWWIINPD
K241-ac IINPDGGkSGKAPRR
S242 INPDGGkSGKAPRRR
S252-p APRRRAVsMDNSNkY
K258-ac VsMDNSNkYTKSRGR
K270-ac RGRAAKKkAALQAAP
S279-p ALQAAPEsADDsPsQ
S283-p APEsADDsPsQLSkW
S285-p EsADDsPsQLSkWPG
S288 DDsPsQLSkWPGsPt
K289-ac DsPsQLSkWPGsPtS
S293-p QLSkWPGsPtSRssD
T295-p SkWPGsPtSRssDEL
S296 kWPGsPtSRssDELD
S298-p PGsPtSRssDELDAW
S299-p GsPtSRssDELDAWT
T306 sDELDAWTDFRSRTN
S310 DAWTDFRSRTNsNAs
S314-p DFRSRTNsNAsTVsG
S317-p SRTNsNAsTVsGRLS
T318 RTNsNAsTVsGRLSP
S320-p NsNAsTVsGRLSPIL
S343 QDDDGPLSPMLYSSS
A394 DDLLDNIALPPSQPS
S398 DNIALPPSQPSPPGG
S412-p GLMQRGSsFPYTAKs
S419-p sFPYTAKssGLGsPt
S420-p FPYTAKssGLGsPtG
S424-p AKssGLGsPtGsFNS
T426-p ssGLGsPtGsFNStV
S428-p GLGsPtGsFNStVFG
T432-p PtGsFNStVFGPSSL
S438 StVFGPSSLNSLRQS
S550 LGGSRALSNSVSNMG
S554 RALSNSVSNMGLSDS
K568-ac SSSLGSAkHQQQsPA
S573-p SAkHQQQsPASQSMQ
S587 QTLSDSLSGSSLYSA
S625 SLECDMESIIRSELM
S643 GLDFNFDSLISTQNV
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
  rat

 
S7-p _MAEAPAsPVPLsPL
S12-p PAsPVPLsPLEVELD
S26 DPEFEPQSRPRSCtW
S30 EPQSRPRSCtWPLQR
T32-p QSRPRSCtWPLQRPE
S43 QRPELQASPAKPSGE
S48 QASPAKPSGETAADS
S55 SGETAADSMIPEEDD
S89 GVSSALGSGLLLEDS
S160 RNAWGNLSYADLITR
Y161 NAWGNLSYADLITRA
T178 SSPDKRLTLSQIYEW
Y183 RLTLSQIYEWMVRCV
S208 SSAGWKNSIRHNLSL
S214 NSIRHNLSLHSRFMR
S230 QNEGTGKSSWWIINP
S231 NEGTGKSSWWIINPD
K241 IINPDGGKSGKAPRR
S242 INPDGGKSGKAPRRR
S252-p APRRRAVsMDNSNkY
K258-ac VsMDNSNkYTKSRGR
K270 RGRAAKKKAALQAAP
S279 ALQAAPESADDsPSQ
S283-p APESADDsPSQLSKW
S285 ESADDsPSQLSKWPG
S288 DDsPSQLSKWPGsPT
K289 DsPSQLSKWPGsPTS
S293-p QLSKWPGsPTSRSSD
T295 SKWPGsPTSRSSDEL
S296 KWPGsPTSRSSDELD
S298 PGsPTSRSSDELDAW
S299 GsPTSRSSDELDAWT
T306 SDELDAWTDFRSRTN
S310 DAWTDFRSRTNSNAS
S314 DFRSRTNSNASTVSG
S317 SRTNSNASTVSGRLS
T318 RTNSNASTVSGRLSP
S320 NSNASTVSGRLSPIL
S343 QDDDGPLSPMLYSSS
A394 DDLLDNIALPPSQAS
S398 DNIALPPSQASPPGG
S412 GLMQRSSSFPYTAKS
S419 SFPYTAKSSGLGSPT
S420 FPYTAKSSGLGSPTS
S424 AKSSGLGSPTSSFNS
T426 SSGLGSPTSSFNSTV
S428 GLGSPTSSFNSTVFG
T432 PTSSFNSTVFGPASL
S438 STVFGPASLNSLRQS
S550 LGGSRALSNSVSNMG
S554 RALSNSVSNMGLSDS
K568 SSSLGSAKHQQQSPV
S573 SAKHQQQSPVSQSMQ
S587 QTLSDSLSGSSLYSA
S625 SLECDMESIIRSELM
S643 GLDFNFDSLISTQNV
9464 : Phospho-FoxO1 (Thr24)/FoxO3a (Thr32) Antibody
9466 : Phospho-FoxO3a (Ser253) Antibody
13129 : Phospho-FoxO3a (Ser253) (D18H8) Rabbit mAb
5538 : Phospho-FoxO3a (Ser294) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
9465 : Phospho-FoxO3a (Ser318/321) Antibody
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