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FOXO3A (human)

Overview FOXO3A a transcription factors of the forkhead family. Contains 1 fork-head domain. May regulate apoptosis through control of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Note: This description may include information from UniProtKB. Protein type: Transcription factor; Autophagy; DNA binding protein Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; identical protein binding; protein binding; DNA binding; sequence-specific DNA binding; double-stranded DNA binding; transcription factor activity; DNA bending activity; transcription factor binding; protein kinase binding Biological Process: tissue development; nerve growth factor receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator; apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; regulation of translation; regulation of transcription factor activity; response to stress; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; initiation of primordial ovarian follicle growth; positive regulation of erythrocyte differentiation; antral ovarian follicle growth; ovulation from ovarian follicle; pattern specification process; oocyte maturation; regulation of cell proliferation; embryonic development; induction of apoptosis; insulin receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus Reference #:  O43524 (UniProtKB) Alt. Names/Synonyms: AF6q21; AF6q21 protein; DKFZp781A0677; FKHRL1; FKHRL1P2; forkhead box O3; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3; FOXO3A; MGC12739; MGC31925 Gene Symbols: FOXO3 Molecular weight: 71,277 Da Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  GPCRs Signaling to MAPK/Erk  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXO3A 2K86 - A=151-251 (human) 2UZK - A/C=158-253 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2K86 2UZK  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S253‑p apoptosis, inhibited: S253‑p, S315‑p cell cycle regulation: S7‑p, S253‑p, S315‑p, S644‑p cell growth, altered: S294‑p, S344‑p, S425‑p transcription, altered: T32‑p, S253‑p, S315‑p transcription, induced: S626‑p inhibition: T32‑p, S253‑p, S294‑p, S344‑p, S425‑p, S644‑p intracellular localization: S7‑p, T32‑p, S209‑p, S253‑p, S315‑p, S644‑p molecular association, regulation: T32‑p, S209‑p, S253‑p, S294‑p, S344‑p, S425‑p, S626‑p phosphorylation: S253‑p protein degradation: S294‑p, S344‑p, S425‑p, S644‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	23		S7-p	_MAEAPAsPAPLsPL
1	18		S12-p	PAsPAPLsPLEVELD
0	2		S30-p	EPQSRPRsCtWPLQR
54	82		T32-p	QSRPRsCtWPLQRPE
0	2		S43-p	QRPELQAsPAKPSGE
0	1		S48	QAsPAKPSGETAADS
0	1		S55	SGETAADSMIPEEED
1	0		S90	GGSGTLGSGLLLEDS
0	1		Y162-p	NAWGNLSyADLITRA
2	0		T179-p	SSPDKRLtLSQIyEW
0	5		Y184-p	RLtLSQIyEWMVRCV
3	0		S209-p	SSAGWKNsIRHNLsL
1	1		S215-p	NsIRHNLsLHSRFMR
1	0		S231-p	QNEGTGKssWWIINP
1	0		S232-p	NEGTGKssWWIINPD
2	0		K242-a	IINPDGGksGKAPRR
1	0		S243-p	INPDGGksGKAPRRR
17	64		S253-p	APRRRAVsMDNSNkY
2	0		K259-a	VsMDNSNkYTKSRGR
1	0		K271	RGRAAKKKAALQTAP
0	5		S280-p	ALQTAPEsADDsPsQ
1	12		S284-p	APEsADDsPsQLskW
0	2		S286-p	EsADDsPsQLskWPG
0	2		S289-p	DDsPsQLskWPGsPt
2	0		K290-a	DsPsQLskWPGsPts
3	69		S294-p	QLskWPGsPtsRsSD
0	1		T296-p	skWPGsPtsRsSDEL
0	2		S297-p	kWPGsPtsRsSDELD
0	3		S299-p	PGsPtsRsSDELDAW
1	2		S300	GsPtsRsSDELDAWT
3	1		S315-p	DFRSRTNsNAstVsG
5	1		S318-p	SRTNsNAstVsGRLS
0	1		T319-p	RTNsNAstVsGRLSP
6	0		S321-p	NsNAstVsGRLSPIM
2	1		S344-p	QDDDAPLsPMLYSSS
0	1		T395-p	DDLLDNItLPPsQPS
2	0		S399-p	DNItLPPsQPSPTGG
4	1		S413-p	GLMQRSSsFPYTTKG
0	1		G420	sFPYTTKGsGLGsPt
0	2		S421-p	FPYTTKGsGLGsPtS
3	3		S425-p	TKGsGLGsPtSSFNS
1	2		T427-p	GsGLGsPtSSFNSTV
0	1		S439-p	STVFGPSsLNSLRQS
0	1		S551-p	LGGSRALsNSVsNMG
2	0		S555-p	RALsNSVsNMGLSES
2	0		K569-a	SSSLGSAkHQQQSPV
1	0		S574	SAkHQQQSPVSQSMQ
2	0		S588-p	QTLSDSLsGSSLYST
3	0		S626-p	SLECDMEsIIRSELM
1	0		S644-p	GLDFNFDsLISTQNV

	mouse
S7-p	_MAEAPAsPVPLsPL
S12-p	PAsPVPLsPLEVELD
S30	EPQSRPRSCtWPLQR
T32-p	QSRPRSCtWPLQRPE
S43-p	QRPELQAsPAKPsGE
S48-p	QAsPAKPsGETAADs
S55-p	sGETAADsMIPEEDD
S89-p	GVSSTLGsGLLLEDS
Y161	NAWGNLSYADLITRA
T178	SSPDKRLTLSQIYEW
Y183	RLTLSQIYEWMVRCV
S208	SSAGWKNSIRHNLSL
S214	NSIRHNLSLHSRFMR
S230	QNEGTGKSSWWIINP
S231	NEGTGKSSWWIINPD
K241-a	IINPDGGkSGKAPRR
S242	INPDGGkSGKAPRRR
S252-p	APRRRAVsMDNSNkY
K258-a	VsMDNSNkYTKSRGR
K270-a	RGRAAKKkAALQAAP
S279-p	ALQAAPEsADDsPsQ
S283-p	APEsADDsPsQLSkW
S285-p	EsADDsPsQLSkWPG
S288	DDsPsQLSkWPGsPt
K289-a	DsPsQLSkWPGsPtS
S293-p	QLSkWPGsPtSRssD
T295-p	SkWPGsPtSRssDEL
S296	kWPGsPtSRssDELD
S298-p	PGsPtSRssDELDAW
S299-p	GsPtSRssDELDAWT
S314-p	DFRSRTNsNAsTVsG
S317-p	SRTNsNAsTVsGRLS
T318	RTNsNAsTVsGRLSP
S320-p	NsNAsTVsGRLSPIL
S343	QDDDGPLSPMLYSSS
A394	DDLLDNIALPPSQPS
S398	DNIALPPSQPSPPGG
S412-p	GLMQRGSsFPYTAKs
S419-p	sFPYTAKsSGLGsPt
S420	FPYTAKsSGLGsPtG
S424-p	AKsSGLGsPtGSFNS
T426-p	sSGLGsPtGSFNSTV
S438	STVFGPSSLNSLRQS
S550	LGGSRALSNSVSNMG
S554	RALSNSVSNMGLSDS
K568-a	SSSLGSAkHQQQsPA
S573-p	SAkHQQQsPASQSMQ
S587	QTLSDSLSGSSLYSA
S625	SLECDMESIIRSELM
S643	GLDFNFDSLISTQNV

	rat
S7	_MAEAPASPVPLSPL
S12	PASPVPLSPLEVELD
S30	EPQSRPRSCtWPLQR
T32-p	QSRPRSCtWPLQRPE
S43	QRPELQASPAKPSGE
S48	QASPAKPSGETAADS
S55	SGETAADSMIPEEDD
S89	GVSSALGSGLLLEDS
Y161	NAWGNLSYADLITRA
T178	SSPDKRLTLSQIYEW
Y183	RLTLSQIYEWMVRCV
S208	SSAGWKNSIRHNLSL
S214	NSIRHNLSLHSRFMR
S230	QNEGTGKSSWWIINP
S231	NEGTGKSSWWIINPD
K241	IINPDGGKSGKAPRR
S242	INPDGGKSGKAPRRR
S252-p	APRRRAVsMDNSNKY
K258	VsMDNSNKYTKSRGR
K270	RGRAAKKKAALQAAP
S279	ALQAAPESADDSPSQ
S283	APESADDSPSQLSKW
S285	ESADDSPSQLSKWPG
S288	DDSPSQLSKWPGsPT
K289	DSPSQLSKWPGsPTS
S293-p	QLSKWPGsPTSRSSD
T295	SKWPGsPTSRSSDEL
S296	KWPGsPTSRSSDELD
S298	PGsPTSRSSDELDAW
S299	GsPTSRSSDELDAWT
S314	DFRSRTNSNASTVSG
S317	SRTNSNASTVSGRLS
T318	RTNSNASTVSGRLSP
S320	NSNASTVSGRLSPIL
S343	QDDDGPLSPMLYSSS
A394	DDLLDNIALPPSQAS
S398	DNIALPPSQASPPGG
S412	GLMQRSSSFPYTAKS
S419	SFPYTAKSSGLGSPT
S420	FPYTAKSSGLGSPTS
S424	AKSSGLGSPTSSFNS
T426	SSGLGSPTSSFNSTV
S438	STVFGPASLNSLRQS
S550	LGGSRALSNSVSNMG
S554	RALSNSVSNMGLSDS
K568	SSSLGSAKHQQQSPV
S573	SAKHQQQSPVSQSMQ
S587	QTLSDSLSGSSLYSA
S625	SLECDMESIIRSELM
S643	GLDFNFDSLISTQNV

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