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FOXO1A (human)

Overview FOXO1A a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Nuclear receptor co-regulator; Transcription factor Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; protein phosphatase 2A binding; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; DNA bending activity; transcription factor binding; protein kinase binding Biological Process: fat cell differentiation; tissue development; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of transcription, DNA-dependent; thermoregulation; positive regulation of gluconeogenesis; regulation of transcription factor activity; organ development; epidermal growth factor receptor signaling pathway; blood vessel development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; cellular response to starvation; negative regulation of fat cell differentiation; negative regulation of stress-activated MAPK cascade; endocrine pancreas development; pattern specification process; regulation of cell proliferation; embryonic development; protein amino acid acetylation; insulin receptor signaling pathway; cell glucose homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of apoptosis Reference #:  Q12778 (UniProtKB) Alt. Names/Synonyms: FKH1; FKHR; forkhead box O1; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; forkhead homolog in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOXO1; FOXO1A Gene Symbols: FOXO1 Molecular weight: 69,662 Da Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  B Cell Receptor Signaling  |  Cell Cycle: G1/S Checkpoint  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXO1A 3CO6 - C=150-249 (human) 3CO7 - C/F=150-266 (human) 3COA - C/F=150-266 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3CO6 3CO7 3COA  |  Phospho3D  |  DISEASE 136533 268220  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
apoptosis, altered: S319‑p apoptosis, induced: S249‑p apoptosis, inhibited: S249‑p cell cycle regulation: S249‑p transcription, altered: T24‑p, S249‑p, S256‑p, S287‑p, S298‑p, S319‑p, S329‑p, S383‑p, S394‑p, T402‑p, S416‑p, S418‑p transcription, induced: S249‑p inhibition: S249‑p, S256‑p intracellular localization: T24‑p, K222‑a, K245‑a, K248‑a, S249‑p, S256‑p, K262‑a, K265‑a, K274‑a, S287‑p, K294‑a, S298‑p, S319‑p, S322‑p, S325‑p, S329‑p, S383‑p, S394‑p, T402‑p, S416‑p, S418‑p molecular association, regulation: T24‑p, S249‑p, S256‑p phosphorylation: T24‑p, K222‑a, K245‑a, K248‑a, S256‑p, K262‑a, K265‑a, K274‑a, K294‑a protein degradation: S256‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
42	38		T24-p	LPRPRSCtWPLPRPE
2	0		S212-p	SSAGWKNsIRHNLsL
1	0		S218-p	NsIRHNLsLHSkFIR
1	0		K222-a	HNLsLHSkFIRVQNE
1	0		S234-p	QNEGTGKssWWMLNP
1	0		S235-p	NEGTGKssWWMLNPE
5	0		K245-a	MLNPEGGkSGksPrR
5	0		K248-a	PEGGkSGksPrRrAA
10	2		S249-p	EGGkSGksPrRrAAs
1	0		R251-m	GkSGksPrRrAAsMD
1	0		R253-m	SGksPrRrAAsMDNN
65	37		S256-p	sPrRrAAsMDNNSkF
2	0		K262-a	AsMDNNSkFAkSRSR
4	0		K265-a	DNNSkFAkSRSRAAK
1	0		K274-a	RSRAAKKkASLQSGQ
4	7		S287-p	GQEGAGDsPGSQFsk
0	1		S293-p	DsPGSQFskWPAsPG
1	0		K294-a	sPGSQFskWPAsPGs
5	29		S298-p	QFskWPAsPGsHsND
0	7		S301-p	kWPAsPGsHsNDDFD
0	6		S303-p	PAsPGsHsNDDFDNW
1	0		T317-gl	WSTFRPRtssNAsTI
1	0		S318-gl	STFRPRtssNAsTIs
20	19		S319-p	TFRPRtssNAsTIsG
6	0		S322-p	PRtssNAsTIsGRLs
5	0		S325-p	ssNAsTIsGRLsPIM
8	13		S329-p	sTIsGRLsPIMTEQD
0	1		T333	GRLsPIMTEQDDLGE
1	0		S383-p	DNLNLLSsPTSLTVS
1	0		S394-p	LTVSTQSsPGTMMQQ
1	0		T402-p	PGTMMQQtPCYSFAP
4	0		S416-p	PPNTSLNsPsPNYQK
4	0		S418-p	NTSLNsPsPNYQKYT
2	1		S432-p	TYGQSSMsPLPQMPI
0	1		S468	LLKELLTSDsPPHND
3	2		S470-p	KELLTSDsPPHNDIM
3	0		T478	PPHNDIMTPVDPGVA
1	0		S502	NVMMGPNSVMsTYGs
0	1		S505-p	MGPNSVMsTYGsQAS
0	1		S509-p	SVMsTYGsQASHNKM
1	0		S550-gl	VSTMPHTsGMNRLTQ
1	0		T556	TsGMNRLTQVKTPVQ
1	0		T560	NRLTQVKTPVQVPLP
0	1		K597-a	MGLLHQEkLPSDLDG
1	0		T648-gl	FPHSVKTtTHsWVsG
0	1		S651-p	SVKTtTHsWVsG___
1	0		S654-gl	TtTHsWVsG______

	mouse
T24-p	LPRQRSCtWPLPRPE
S209	SSAGWKNSIRHNLSL
S215	NSIRHNLSLHSKFIR
K219	HNLSLHSKFIRVQNE
S231	QNEGTGKSSWWMLNP
S232	NEGTGKSSWWMLNPE
K242	MLNPEGGKSGKsPRR
K245	PEGGKSGKsPRRRAA
S246-p	EGGKSGKsPRRRAAs
R248	GKSGKsPRRRAAsMD
R250	SGKsPRRRAAsMDNN
S253-p	sPRRRAAsMDNNSKF
K259	AsMDNNSKFAKSRGR
K262	DNNSKFAKSRGRAAK
K271	RGRAAKKKASLQSGQ
S284-p	GQEGPGDsPGSQFSK
S290	DsPGSQFSKWPAsPG
K291	sPGSQFSKWPAsPGS
S295-p	QFSKWPAsPGSHsND
S298	KWPAsPGSHsNDDFD
S300-p	PAsPGSHsNDDFDNW
T314	WSTFRPRTSsNAsTI
S315	STFRPRTSsNAsTIs
S316-p	TFRPRTSsNAsTIsG
S319-p	PRTSsNAsTIsGRLs
S322-p	SsNAsTIsGRLsPIM
S326-p	sTIsGRLsPIMtEQD
T330-p	GRLsPIMtEQDDLGD
S380-p	DNLNLLSsPTSLTVS
S391-p	LTVSTQSsPGSMMQQ
T399-p	PGSMMQQtPCYSFAP
S413-p	PPNTSLNsPsPNYSK
S415-p	NTSLNsPsPNYSKYT
S429-p	TYGQSSMsPLPQMPM
S465-p	LLKELLTsDsPPHND
S467-p	KELLTsDsPPHNDIM
S475-p	PPHNDIMsPVDPGVA
S499-p	NVMMGPNsVMPAYGS
P502	MGPNsVMPAYGSQAS
S506	sVMPAYGSQASHNKM
S547	VNTMPHTSAMNRLtP
T553-p	TSAMNRLtPVKtPLQ
T557-p	NRLtPVKtPLQVPLS
K594	MGVLHQEKLPSDLDG
T645	FPHSVKTTTHSWVSG
S648	SVKTTTHSWVSG___
S651	TTTHSWVSG______

	rat
T24-p	LPRQRSCtWPLPRPE
S206-p	SSAGWKNsIRHNLSL
S212	NsIRHNLSLHSKFIR
K216	HNLSLHSKFIRVQNE
S228	QNEGTGKSSWWMLNP
S229	NEGTGKSSWWMLNPE
K239	MLNPEGGKSGKsPRR
K242	PEGGKSGKsPRRRAA
S243-p	EGGKSGKsPRRRAAs
R245	GKSGKsPRRRAAsMD
R247	SGKsPRRRAAsMDNN
S250-p	sPRRRAAsMDNNSKF
K256	AsMDNNSKFAKSRGR
K259	DNNSKFAKSRGRAAK
K268	RGRAAKKKASLQSGQ
S281-p	GQEGPGDsPGSQFSK
S287	DsPGSQFSKWPASPG
K288	sPGSQFSKWPASPGS
S292	QFSKWPASPGSHSND
S295	KWPASPGSHSNDDFD
S297	PASPGSHSNDDFDNW
T311	WSTFRPRTSsNAsTI
S312	STFRPRTSsNAsTIs
S313-p	TFRPRTSsNAsTIsG
S316-p	PRTSsNAsTIsGRLs
S319-p	SsNAsTIsGRLsPIM
S323-p	sTIsGRLsPIMTEQD
T327	GRLsPIMTEQDDLGD
S377	DNLNLLSSPTSLTVS
S388	LTVSTQSSPGSMMQQ
T396	PGSMMQQTPCYSFAP
S410	PPNTSLNSPSPNYAK
S412	NTSLNSPSPNYAKYT
S426	TYGQSSMSPVPQMPM
S462	LLKELLTSDSPPHND
S464	KELLTSDSPPHNDIM
S472	PPHNDIMSPVDPGVA
S496	NVLMGPNSVMPAYGS
P499	MGPNSVMPAYGSQAP
S503	SVMPAYGSQAPHNKM
S544	VNTMPHTSAMNRLTP
T550	TSAMNRLTPVKTPLQ
T554	NRLTPVKTPLQVPLS
K591	MGVLHQEKLPSDLDG
T642	FPHSVKTTTHSWVSG
S645	SVKTTTHSWVSG___
S648	TTTHSWVSG______

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