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Protein Page:
Ezrin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ezrin a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: cortical cytoskeleton; extracellular space; microvillus; focal adhesion; basolateral plasma membrane; T-tubule; actin filament; cytosol; lipid raft; actin cytoskeleton; ruffle; extrinsic to membrane; membrane; apical part of cell; microvillus membrane; apical plasma membrane; plasma membrane; nucleolus; uropod; filopodium
Molecular Function: actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding
Biological Process: actin filament bundle formation; axon guidance; regulation of cell shape; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment and/or maintenance of apical/basal cell polarity
Reference #:  P15311 (UniProtKB)
Alt. Names/Synonyms: CVIL; CVL; Cytovillin; cytovillin 2; DKFZp762H157; EZR; EZRI; Ezrin; FLJ26216; MGC1584; p81; VIL2; villin 2 (ezrin); Villin-2
Gene Symbols: EZR
Molecular weight: 69,413 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Ezrin

Protein Structure Not Found.


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Sites Implicated In
cell adhesion, altered: Y146‑p, T567‑p
cell differentiation, altered: T567‑p
cell growth, altered: Y146‑p
cell motility, altered: Y146‑p, Y354‑p, Y478‑p, T567‑p
cytoskeletal reorganization: S66‑p, Y146‑p, Y354‑p, Y478‑p, T567‑p
activity, induced: Y354‑p, T567‑p
intracellular localization: S66‑p, Y146‑p, Y354‑p, T567‑p
molecular association, regulation: Y146‑p, Y191‑p, Y354‑p, Y478‑p, T567‑p
phosphorylation: Y146‑p, Y191‑p, T567‑p
protein conformation: T567‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K3-ub _____MPkPINVRVT
0 2 K35-ac QLFDQVVkTIGLREV
0 4 K35-ub QLFDQVVkTIGLREV
0 1 T57-p VDNKGFPtWLkLDKK
0 3 K60-ac KGFPtWLkLDKKVsA
0 1 K60-sc KGFPtWLkLDKKVsA
2 0 S66-p LkLDKKVsAQEVRkE
0 2 K72-ub VsAQEVRkENPLQFk
0 5 K79-ac kENPLQFkFRAkFYP
0 39 K79-ub kENPLQFkFRAkFYP
0 18 K83-ub LQFkFRAkFYPEDVA
0 1 K107-ub KLFFLQVkEGILsDE
0 3 S112-p QVkEGILsDEIyCPP
0 15 Y116-p GILsDEIyCPPETAV
0 1 Y137-p VQAKFGDyNkEVHkS
0 1 K139-ac AKFGDyNkEVHkSGy
0 11 K139-ub AKFGDyNkEVHkSGy
0 2 K143-ub DyNkEVHkSGyLSsE
11 1 Y146-p kEVHkSGyLSsERLI
0 1 S149-p HkSGyLSsERLIPQR
0 13 K162-ub QRVMDQHkLTRDQWE
0 1 K184-ac AEHRGMLkDNAMLEy
0 2 K184-ub AEHRGMLkDNAMLEy
2 2 Y191-p kDNAMLEyLKIAQDL
0 2 Y201-p IAQDLEMyGINyFEI
0 2 Y205-p LEMyGINyFEIkNkK
0 3 K209-ub GINyFEIkNkKGTDL
0 1 K211-ub NyFEIkNkKGTDLWL
0 1 K230-ub LGLNIYEkDDkLTPk
0 2 K233-ub NIYEkDDkLTPkIGF
1 0 T235 YEkDDkLTPkIGFPW
0 7 K237-ub kDDkLTPkIGFPWsE
0 1 S243-p PkIGFPWsEIRNISF
0 27 K253-ac RNISFNDkKFVIkPI
0 3 K253-ub RNISFNDkKFVIkPI
0 1 K254 NISFNDkKFVIkPID
0 1 K258-ac NDkKFVIkPIDKkAP
0 7 K263-ub VIkPIDKkAPDFVFy
0 253 Y270-p kAPDFVFyAPRLRIN
0 8 Y291-p CMGNHELyMRRRKPD
0 3 K306-ub TIEVQQMkAQAREEK
0 62 T332-p TEKKRREtVEREkEQ
0 2 K337-ub REtVEREkEQMMREk
0 3 K344-ub kEQMMREkEELMLRL
9 244 Y354-p LMLRLQDyEEkTKKA
0 1 K357-ub RLQDyEEkTKKAERE
0 6 R363 EkTKKAERELsEQIQ
0 2 S366-p KKAERELsEQIQRAL
0 1 R371 ELsEQIQRALQLEEE
0 1 K412-ac RQAVDQIksQEQLAA
0 3 K412-ub RQAVDQIksQEQLAA
0 2 S413-p QAVDQIksQEQLAAE
0 169 Y424-p LAAELAEytAkIALL
0 12 T425-p AAELAEytAkIALLE
0 2 K427-ub ELAEytAkIALLEEA
0 2 K438-ub LEEARRRkEDEVEEW
0 2 K450-ub EEWQHRAkEAQDDLV
0 2 K458-ub EAQDDLVkTKEELHL
0 1 T468-p EELHLVMtAPPPPPP
7 135 Y478-p PPPPPPVyEPVsyHV
0 29 S482-p PPVyEPVsyHVQEsL
0 35 Y483-p PVyEPVsyHVQEsLQ
0 5 S488-p VsyHVQEsLQDEGAE
0 1 T497-p QDEGAEPtGySAELS
0 44 Y499-p EGAEPtGySAELSSE
0 2 K523-ub KRITEAEkNERVQRQ
0 7 S535-p QRQLLTLssELsQAR
0 1 S536-p RQLLTLssELsQARD
0 12 S539-p LTLssELsQARDENK
0 1 K546 sQARDENKRtHNDII
0 1 T548-p ARDENKRtHNDIIHN
41 20 T567-p QGRDKYKtLRQIRQG
0 1 T576-p RQIRQGNtKQRIDEF
3144 : Phospho-Ezrin (Tyr353) Antibody
5484 : Phospho-Ezrin (Tyr353) (D66D3) Rabbit mAb
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
  mouse

 
K3-ub _____MPkPINVRVT
K35 QLFDQVVKTIGLREV
K35 QLFDQVVKTIGLREV
T57-p VDNKGFPtWLKLDKK
K60 KGFPtWLKLDKKVSA
K60 KGFPtWLKLDKKVSA
S66 LKLDKKVSAQEVRkE
K72-ub VSAQEVRkENPVQFk
K79 kENPVQFKFRAkFYP
K79-ub kENPVQFkFRAkFYP
K83-ub VQFkFRAkFYPEDVA
K107 KLFFLQVKDGILSDE
S112 QVKDGILSDEIYCPP
Y116 GILSDEIYCPPETAV
Y137 VQAKFGDYNkEMHkS
K139 AKFGDYNKEMHkSGy
K139-ub AKFGDYNkEMHkSGy
K143-ub DYNkEMHkSGyLSSE
Y146-p kEMHkSGyLSSERLI
S149 HkSGyLSSERLIPQR
K162-ub QRVMDQHkLSRDQWE
K184 AEHRGMLKDSAMLEy
K184-ub AEHRGMLkDSAMLEy
Y191-p kDSAMLEyLKIAQDL
Y201 IAQDLEMYGINYFEI
Y205 LEMYGINYFEIkNKK
K209-ub GINYFEIkNKKGTDL
K211 NYFEIkNKKGTDLWL
K230 LGLNIYEKDDKLtPk
K233 NIYEKDDKLtPkIGF
T235-p YEKDDKLtPkIGFPW
K237-ub KDDKLtPkIGFPWSE
S243 PkIGFPWSEIRNISF
K253-ac RNISFNDkkFVIKPI
K253-ub RNISFNDkkFVIKPI
K254-ac NISFNDkkFVIKPID
K258 NDkkFVIKPIDKkAP
K263-ub VIKPIDKkAPDFVFy
Y270-p kAPDFVFyAPRLRIN
Y291-p CMGNHELyMRRRKPD
K306-ub TIEVQQMkAQAREEK
T332 TEKKRRETVEREkEQ
K337-ub RETVEREkEQMLREk
K344-ub kEQMLREkEELMLRL
Y354-p LMLRLQDyEQKTKRA
K357 RLQDyEQKTKRAEkE
K363-ub QKTKRAEkELSEQIE
S366 KRAEkELSEQIEkAL
K371-ub ELSEQIEkALQLEEE
K412 RQAQDQIKSQEQLAA
K412-ub RQAQDQIkSQEQLAA
S413 QAQDQIkSQEQLAAE
Y424 LAAELAEYTAKIALL
T425 AAELAEYTAKIALLE
K427 ELAEYTAKIALLEEA
K438-ub LEEARRRkEDEVEEW
K450-ub EEWQHRAkEAQDDLV
K458-ub EAQDDLVkTKEELHL
T468 EELHLVMTAPPPPPP
Y478-p PPPPPPVyEPVNyHV
N482 PPVyEPVNyHVQEGL
Y483-p PVyEPVNyHVQEGLQ
G488 VNyHVQEGLQDEGAE
M497 QDEGAEPMGYSAELS
Y499 EGAEPMGYSAELSSE
K523-ub KRITEAEkNERVQRQ
S535-p QRQLLTLsNELSQAR
N536 RQLLTLsNELSQARD
S539 LTLsNELSQARDENk
K546-ub SQARDENkRTHNDII
T548 ARDENkRTHNDIIHN
T567-p QGRDKYKtLRQIRQG
T576 RQIRQGNTKQRIDEF
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
  rat

 
K3 _____MPKPINVRVT
K35-ac QLFDQVVkTIGLREV
K35 QLFDQVVKTIGLREV
T57-p VDNKGFPtWLkLDKK
K60-ac KGFPtWLkLDKKVSA
K60 KGFPtWLKLDKKVSA
S66 LkLDKKVSAQEVRKE
K72 VSAQEVRKENPVQFk
K79-ac KENPVQFkFRAKFYP
K79 KENPVQFKFRAKFYP
K83 VQFkFRAKFYPEDVA
K107 KLFFLQVKEGILSDE
S112 QVKEGILSDEIYCPP
Y116 GILSDEIYCPPETAV
Y137 VQAKFGDYNkEMHKS
K139-ac AKFGDYNkEMHKSGY
K139 AKFGDYNKEMHKSGY
K143 DYNkEMHKSGYLSsE
Y146 kEMHKSGYLSsERLI
S149-p HKSGYLSsERLIPQR
K162 QRVMDQHKLSRDQWE
K184-ac AEHRGMLkDSAMLEY
K184 AEHRGMLKDSAMLEY
Y191 kDSAMLEYLKIAQDL
Y201 IAQDLEMYGINYFEI
Y205 LEMYGINYFEIKNKK
K209 GINYFEIKNKKGTDL
K211 NYFEIKNKKGTDLWL
K230 LGLNIYEKDDKLTPK
K233 NIYEKDDKLTPKIGF
T235 YEKDDKLTPKIGFPW
K237 KDDKLTPKIGFPWsE
S243-p PKIGFPWsEIRNISF
K253-ac RNISFNDkkFVIkPI
K253 RNISFNDKkFVIkPI
K254-ac NISFNDkkFVIkPID
K258-ac NDkkFVIkPIDKKAP
K263 VIkPIDKKAPDFVFy
Y270-p KAPDFVFyAPRLRIN
Y291 CMGNHELYMRRRKPD
K306 TIEVQQMKAQAREEK
T332-p TEKKRREtVEREKEQ
K337 REtVEREKEQMLREK
K344 KEQMLREKEELMLRL
F354 LMLRLQDFEQKTKRA
K357 RLQDFEQKTKRAEkE
K363-ub QKTKRAEkELSEQIE
S366 KRAEkELSEQIEKAL
K371 ELSEQIEKALQLEEE
K412 RQAQDQIKSQEQLAA
K412 RQAQDQIKSQEQLAA
S413 QAQDQIKSQEQLAAE
Y424 LAAELAEYTAKIALL
T425 AAELAEYTAKIALLE
K427 ELAEYTAKIALLEEA
K438 LEEARRRKEDEVEEW
K450 EEWQHRAKEAQDDLV
K458 EAQDDLVKTKEELHL
T468 EELHLVMTAPPPPPP
Y478 PPPPPPVYEPVNYHV
N482 PPVYEPVNYHVQEGL
Y483 PVYEPVNYHVQEGLQ
G488 VNYHVQEGLQDEGAE
M497 QDEGAEPMGYSAELS
Y499 EGAEPMGYSAELSSE
K523 KRITEAEKNERVQRQ
S535-p QRQLLTLsNELSQAR
N536 RQLLTLsNELSQARD
S539 LTLsNELSQARDENK
K546 SQARDENKRTHNDII
T548 ARDENKRTHNDIIHN
T567-p QGRDKYKtLRQIRQG
T576 RQIRQGNTKQRIDEF
3141 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) Antibody
3149 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb
3726 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (48G2) Rabbit mAb (ELISA Specific)
13756 : Phospho-Ezrin (Thr567)/Radixin (Thr564)/Moesin (Thr558) (41A3) Rabbit mAb (Biotinylated)
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