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Protein Page:
SHOX (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHOX Controls fundamental aspects of growth and development. Defects in SHOX are the cause of Leri-Weill dyschondrosteosis (LWD). LWD is a dominantly inherited skeletal dysplasia characterized by moderate short stature predominantly because of short mesomelic limb segments. It is often associated with the Madelung deformity of the wrist, comprising bowing of the radius and dorsal dislocation of the distal ulna. Defects in SHOX are a cause of Langer mesomelic dysplasia (LMD). LMD is an autosomal recessive rare skeletal dysplasia characterized by severe short stature owing to shortening and maldevelopment of the mesomelic and rhizomelic segments of the limbs. Associated malformations are rarely reported and intellect is normal in all affected subjects reported to date. Defects in SHOX are a cause of idiopathic short stature (ISS). Idiopathic short stature is usually defined as a height below the third percentile for chronological age or minus 2 standard deviations of national height standards in the absence of specific causative disorders. Belongs to the paired homeobox family. Bicoid subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Chromosomal Location of Human Ortholog: Xp22.33;Yp11.3
Cellular Component: nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; skeletal development
Reference #:  O15266 (UniProtKB)
Alt. Names/Synonyms: GCFX; growth control factor, X-linked; PHOG; Pseudoautosomal homeobox-containing osteogenic protein; short stature homeobox; Short stature homeobox protein; Short stature homeobox-containing protein; SHOX; SHOXY; SS
Gene Symbols: SHOX
Molecular weight: 32,236 Da
Basal Isoelectric point: 7.23  Predict pI for various phosphorylation states
Select Structure to View Below

SHOX

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S106‑p
transcription, induced: S106‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T5-p ___MEELtAFVsKSF
0 1 S9-p EELtAFVsKSFDQKS
0 1 K17-ub KSFDQKSkDGNGGGG
0 1 K30-ac GGGGGGKkDSITYRE
1 1 S106-p EKREDVKsEDEDGQT
0 1 S120-p TKLKQRRsRTNFtLE
0 1 T125-p RRsRTNFtLEQLNEL
0 1 Y141-p RLFDETHyPDAFMRE
  dog

 
T5 ___MEELTAFVSKSF
S9 EELTAFVSKSFDQKS
K17 KSFDQKSKETGGGGG
K29 GGGGGGKKDSITYRE
S105 EKREDVKSEDEDGQT
S119 TKLKQRRSRTNFTLE
T124 RRSRTNFTLEQLNEL
Y140 RLFDETHYPDAFMRE
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