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GLI1 (human)

Overview GLI1 Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Interacts with KIF7. Interacts with ZIC1; the interaction enhances transcription activation. Amplified in glioblastoma cells. Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: C2H2-type zinc finger protein; Transcription factor Cellular Component: cytoplasm; cytosol; nucleus; cilium Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; zinc ion binding; microtubule binding; chromatin binding Biological Process: smoothened signaling pathway; ventral midline development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; positive regulation of transcription, DNA-dependent; digestive tract morphogenesis; notochord regression; osteoblast differentiation; dorsal/ventral pattern formation; cerebellar cortex morphogenesis; pituitary gland development; positive regulation of cell proliferation; epidermal cell differentiation; positive regulation of smoothened signaling pathway; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of DNA replication; proximal/distal pattern formation; lung development; regulation of smoothened signaling pathway Reference #:  P08151 (UniProtKB) Alt. Names/Synonyms: GLI; GLI family zinc finger 1; GLI1; Glioma-associated oncogene; glioma-associated oncogene family zinc finger 1; glioma-associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zinc finger protein GLI1 Gene Symbols: GLI1 Molecular weight: 117,904 Da Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states CST Pathways:  Hedgehog Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below GLI1 2GLI - A=232-391 (human)

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	Sites Implicated In
transcription, altered: T374‑p inhibition: T374‑p intracellular localization: T374‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		S84-p	LTKKRALsISPLSDA
0	1		S132	SIGTMSPSLGFPAQM
1	0		S243-p	DCRWDGCsQEFDSQE
1	0		T304-p	GEKPHKCtFEGCRKS
0	1		K365-a	NEKPYVCkLPGCTkR
0	1		K371-a	CkLPGCTkRYtDPSS
1	0		T374-p	PGCTkRYtDPSSLRK
0	1		S521-p	TRGLKLPsLSHTGtT
0	1		T527-p	PsLSHTGtTVSRRVG
0	1		S538-p	RRVGPPVsLERRSss
1	1		S544-p	VsLERRSssSSSISS
0	1		S545-p	sLERRSssSSSISSA
1	0		S560-p	YTVSRRSsLASPFPP
0	1		S602-p	SARGGGTsPTAASSL
0	1		S622-p	LPMPPWRsRAEYPGY
1	0		S640-p	AGVTRRAsDPAQAAD
0	1		Y800	PKALGGTYSQCPRLE

	mouse
S87	LTKKRALSISPLSDA
S135-p	SIGTMSPsLGFPPQM
S246	DCRWDGCSQEFDSQE
T307	GEKPHKCTFEGCRKS
K368	NEKPYVCKLPGCTKR
K374	CKLPGCTKRYTDPSS
T377	PGCTKRYTDPSSLRK
S523	SRGLKLPSLTHAGAP
A529	PSLTHAGAPVSRRLG
S540	RRLGPPVSLDRRSSS
S546	VSLDRRSSSSSSMSS
S547	SLDRRSSSSSSMSSA
S562	YTVSRRSSLASPFPP
P604	SARGSGTPPTAAHSL
S624	LSVPPWRSRTEYPGY
S642	AGVTRRASDPARAAD
Y801	NKAPGAAYSQCPRLE

	rat
S84	LTKKRALSISPLSDA
S132	SIGTMSPSLGFPPQM
S243	DCRWDGCSQEFDSQE
T304	GEKPHKCTFEGCRKS
K365	NEKPYVCKLPGCTKR
K371	CKLPGCTKRYTDPSS
T374	PGCTKRYTDPSSLRK
S520	SRGLKLPSLTHAGAP
A526	PSLTHAGAPVSRRLG
S537	RRLGPPVSLDRRSSS
S543	VSLDRRSSSSSSISS
S544	SLDRRSSSSSSISSA
S559	YTVSRRSSLASPFPP
P601	SARGSGTPPTAAHSL
S621	LPAPPWRSRAEYPGY
S639	AGVTRRASDPARAAD
Y798-p	TKALGTAyNQCPRLE

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