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Protein Page:
GLI1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLI1 Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Interacts with KIF7. Interacts with ZIC1; the interaction enhances transcription activation. Amplified in glioblastoma cells. Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 12q13.2-q13.3
Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; DNA binding; metal ion binding; microtubule binding; chromatin binding
Biological Process: transcription from RNA polymerase II promoter; smoothened signaling pathway; ventral midline development; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; positive regulation of transcription, DNA-dependent; digestive tract morphogenesis; notochord regression; osteoblast differentiation; cerebellar cortex morphogenesis; dorsal/ventral pattern formation; pituitary gland development; positive regulation of cell proliferation; epidermal cell differentiation; positive regulation of smoothened signaling pathway; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; positive regulation of DNA replication; proximal/distal pattern formation; lung development; regulation of smoothened signaling pathway
Reference #:  P08151 (UniProtKB)
Alt. Names/Synonyms: GLI; GLI family zinc finger 1; GLI1; Glioma-associated oncogene; glioma-associated oncogene family zinc finger 1; glioma-associated oncogene homolog 1 (zinc finger protein); Oncogene GLI; Zinc finger protein GLI1
Gene Symbols: GLI1
Molecular weight: 117,904 Da
Basal Isoelectric point: 6.98  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GLI1

Protein Structure Not Found.


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Sites Implicated In
cell growth, induced: S243‑p, T304‑p
transcription, altered: T374‑p
transcription, induced: S243‑p, T304‑p
activity, inhibited: T374‑p
intracellular localization: T374‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T63-p ARETNSCtEGPLFsS
0 1 S69-p CtEGPLFsSPRSAVK
1 0 S84-p LTKKRALsISPLSDA
0 1 S132 SIGTMSPSLGFPAQM
0 1 S204-p GDMSSPNstGIQDPL
0 1 T205-p DMSSPNstGIQDPLL
1 0 S243-p DCRWDGCsQEFDSQE
1 0 T304-p GEKPHKCtFEGCRKS
0 1 K365-ac NEKPYVCkLPGCTkR
0 1 K371-ac CkLPGCTkRYtDPSS
1 0 T374-p PGCTkRYtDPSSLRK
1 0 K518 PIGTRGLKLPsLSHT
0 1 S521-p TRGLKLPsLSHTGtT
0 1 T527-p PsLSHTGtTVSRRVG
0 1 S538-p RRVGPPVsLERRSss
1 1 S544-p VsLERRSssSSSISS
0 1 S545-p sLERRSssSSSISSA
1 0 S560-p YTVSRRSsLASPFPP
0 1 S602-p SARGGGTsPTAASSL
0 1 S622-p LPMPPWRsRAEYPGY
1 0 S640-p AGVTRRAsDPAQAAD
0 1 Y800 PKALGGTYSQCPRLE
0 1 S934-p SPKFLGGsQVsPsRA
0 1 S937-p FLGGsQVsPsRAKAP
0 1 S939-p GGsQVsPsRAKAPVN
  mouse

 
T63 ARETSSCTEGSLFPP
P69 CTEGSLFPPPPPPRS
S87 LTKKRALSISPLSDA
S135-p SIGTMSPsLGFPPQM
S207 GDMSSPNSTGTQDHL
T208 DMSSPNSTGTQDHLL
S246 DCRWDGCSQEFDSQE
T307 GEKPHKCTFEGCRKS
K368 NEKPYVCKLPGCTKR
K374 CKLPGCTKRYTDPSS
T377 PGCTKRYTDPSSLRK
K520-ac PIGSRGLkLPSLTHA
S523 SRGLkLPSLTHAGAP
A529 PSLTHAGAPVSRRLG
S540 RRLGPPVSLDRRSSS
S546 VSLDRRSSSSSSMSS
S547 SLDRRSSSSSSMSSA
S562 YTVSRRSSLASPFPP
P604 SARGSGTPPTAAHSL
S624 LSVPPWRSRTEYPGY
S642 AGVTRRASDPARAAD
Y801 NKAPGAAYSQCPRLE
S936 SPKFLGGSQVSQSPA
S939 FLGGSQVSQSPAKTP
S941 GGSQVSQSPAKTPAA
  rat

 
T63 ARETSSCTEGSLFPP
P69 CTEGSLFPPPRSSVK
S84 LTKKRALSISPLSDA
S132 SIGTMSPSLGFPPQM
S204 GDMSSPNSTSTQDHL
T205 DMSSPNSTSTQDHLL
S243 DCRWDGCSQEFDSQE
T304 GEKPHKCTFEGCRKS
K365 NEKPYVCKLPGCTKR
K371 CKLPGCTKRYTDPSS
T374 PGCTKRYTDPSSLRK
K517 PIGSRGLKLPSLTHA
S520 SRGLKLPSLTHAGAP
A526 PSLTHAGAPVSRRLG
S537 RRLGPPVSLDRRSSS
S543 VSLDRRSSSSSSISS
S544 SLDRRSSSSSSISSA
S559 YTVSRRSSLASPFPP
P601 SARGSGTPPTAAHSL
S621 LPAPPWRSRAEYPGY
S639 AGVTRRASDPARAAD
Y798-p TKALGTAyNQCPRLE
S932 SPKFLGGSQVSQSPT
S935 FLGGSQVSQSPTKVP
S937 GGSQVSQSPTKVPAA
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