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Protein Page:
ER-beta (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ER-beta a nuclear hormone receptor and transcription factor. Binds and activated by estrogen. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Eight alternatively-spliced isoforms have been described. Isoform beta-cx lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Nuclear receptor
Chromosomal Location of Human Ortholog: 14q23.2
Cellular Component: nucleoplasm; mitochondrion; extracellular region; nucleus
Molecular Function: receptor antagonist activity; protein binding; ligand-dependent nuclear receptor activity; estrogen receptor activity; enzyme binding; DNA binding; zinc ion binding; transcription coactivator activity; steroid hormone receptor activity; estrogen response element binding; transcription factor activity; steroid binding
Biological Process: transcription initiation from RNA polymerase II promoter; estrogen receptor signaling pathway; induction of apoptosis by hormones; neuron migration; vagina development; negative regulation of transcription from RNA polymerase II promoter; uterus development; signal transduction; regulation of transcription, DNA-dependent; ovarian follicle development; cell-cell signaling; positive regulation of transcription factor activity; gene expression; steroid hormone mediated signaling; negative regulation of cell growth; brain development; negative regulation of epithelial cell proliferation
Reference #:  Q92731 (UniProtKB)
Alt. Names/Synonyms: ER-beta; Erb; ESR-BETA; ESR2; ESRB; ESTRB; estrogen receptor 2 (ER beta); Estrogen receptor beta; estrogen receptor beta 4; NR3A2; Nuclear receptor subfamily 3 group A member 2
Gene Symbols: ESR2
Molecular weight: 59,216 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below

ER-beta

Protein Structure Not Found.


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Sites Implicated In
cell growth, inhibited: Y36‑p
transcription, induced: Y36‑p
activity, induced: S87‑p, S105‑p
intracellular localization: S105‑p
molecular association, regulation: Y36‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y36-p SIYIPSSyVDSHHEY
0 1 Y56-p YSPAVMNySIPSNVT
1 1 N61 MNySIPSNVTNLEGG
2 1 N61 MNySIPSNVTNLEGG
1 0 S75 GPGRQTTSPNVLWPT
3 0 S87-p WPTPGHLsPLVVHRQ
4 0 S105-p LYAEPQKsPWCEARS
0 1 S135-p VSGNRCAsPVTGPGS
1 0 S176-p CKAFFKRsIQGHNDY
1 0 S200-p IDKNRRKsCQACRLR
1 0 D236 VRRQRSADEQLHCAG
0 1 S463-p ANLLMLLsHVRHAsN
0 1 S469-p LsHVRHAsNKGMEHL
2 0 Y488-p CKNVVPVyDLLLEML
0 1 S505 HVLRGCKSSITGSEC
  mouse

 
Y36 PIYIPSSYVESRHEY
Y56 YSPAVMNYSVPSsTG
S61-p MNYSVPSsTGNLEGG
S61-gl MNYSVPSsTGNLEGG
S75-p GPVRQTAsPNVLWPT
S87-p WPTSGHLsPLATHCQ
S105-p LYAEPQKsPWCEARS
S135 LGGSGCASPVTSPSA
S176 CKAFFKRSIQGHNDY
S200 IDKNRRKSCQACRLR
S236-p VRRQRSAsEQVHCLN
S463 ANLLMLLSHVRHISN
S469 LSHVRHISNKGMEHL
Y488-p CKNVVPVyDLLLEML
S505-p HTLRGYKsSISGSEC
  rat

 
Y36 PIYIPSSYVDNRHEY
Y56 YSPAVMNYSVPGSTS
S61 MNYSVPGSTSNLDGG
S61 MNYSVPGSTSNLDGG
S75 GPVRLSTSPNVLWPT
S87 WPTSGHLSPLATHCQ
S105 LYAEPQKSPWCEARS
S135 LSGSSCASPVTSPNA
S176 CKAFFKRSIQGHNDY
S200 IDKNRRKSCQACRLR
S236 VRRQRSSSEQVHCLS
S463 ANLLMLLSHVRHISN
S469 LSHVRHISNKGMEHL
Y488 CKNVVPVYDLLLEML
S505 HTLRGYKSSISGSEC
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