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Protein Page:
ER-alpha (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ER-alpha a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor; DNA binding protein
Cellular Component: nucleoplasm; Golgi apparatus; membrane; plasma membrane; integral to membrane; nucleus
Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity
Biological Process: positive regulation of nitric oxide biosynthetic process; estrogen receptor signaling pathway; uterus development; signal transduction; response to estradiol stimulus; regulation of apoptosis; positive regulation of fibroblast proliferation; elevation of cytosolic calcium ion concentration; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; androgen metabolic process; male gonad development; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); gene expression; positive regulation of transcription factor activity; steroid hormone mediated signaling
Reference #:  P03372 (UniProtKB)
Alt. Names/Synonyms: DKFZp686N23123; ER; ER-alpha; Era; ESR; ESR1; ESRA; Estradiol receptor; Estrogen receptor; estrogen receptor 1; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; NR3A1; Nuclear receptor subfamily 3 group A member 1
Gene Symbols: ESR1
Molecular weight: 66,216 Da
Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ER-alpha

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S167‑p
carcinogenesis, altered: S118‑p, S305‑p
carcinogenesis, induced: Y52‑p, Y219‑p
cell growth, altered: S118‑p, S167‑p, S305‑p
cell growth, induced: Y52‑p, Y219‑p, S305‑p
transcription, altered: S46‑p, S47‑p, S104‑p, S106‑p, S118‑p, S167‑p, K266‑ac, K268‑ac, S282‑p, S294‑p, K302‑ac, K302‑ub, K303‑ac, S305‑p, T311‑p, S559‑p
transcription, induced: Y52‑p, S102‑p, S104‑p, S106‑p, S118‑p, S167‑p, Y219‑p, S305‑p, Y537‑p
transcription, inhibited: S236‑p
acetylation: S118‑p, S167‑p
activity, induced: S46‑p, S47‑p, S102‑p, S104‑p, S106‑p, S118‑p, S167‑p, K266‑ac, K268‑ac, S294‑p, K302‑ac, K303‑ac, S305‑p, T311‑p
activity, inhibited: S282‑p, K302‑ub, K303‑ac, S559‑p
intracellular localization: S305‑p, T311‑p
molecular association, regulation: S104‑p, S106‑p, S118‑p, S167‑p, Y219‑p, K266‑ac, K268‑ac, S294‑p, S305‑p, T311‑p, Y537‑p
phosphorylation: S118‑p, S167‑p, S305‑p
protein conformation: S294‑p, S305‑p
protein degradation: S118‑p
protein stabilization: Y52‑p, Y219‑p, Y537‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T7-p _MTMTLHtKAsGMAL
0 1 S10-p MTLHtKAsGMALLHQ
1 0 S10 MTLHtKASGMALLHQ
1 0 K32-ac PLNRPQLkIPLERPL
1 0 S46-p LGEVYLDssKPAVyN
1 0 S47-p GEVYLDssKPAVyNY
1 0 A50 YLDssKPAVyNYPEG
1 0 Y52-p DssKPAVyNYPEGAA
3 1 S102-p GGFPPLNsVsPsPLM
19 1 S104-p FPPLNsVsPsPLMLL
19 1 S106-p PLNsVsPsPLMLLHP
75 2 S118-p LHPPPQLsPFLQPHG
1 0 P152 GPPAFYRPNsDNRRQ
3 2 S154-p PAFYRPNsDNRRQGG
36 3 S167-p GGRERLAsTNDkGSM
1 0 K171-ac RLAsTNDkGSMAMES
1 0 K171-m1 RLAsTNDkGSMAMES
1 0 K171-m2 RLAsTNDkGSMAMES
1 0 K171-sm RLAsTNDkGSMAMES
1 0 K180-m2 SMAMESAkETRYCAV
1 0 K180-sm SMAMESAkETRYCAV
4 1 S212-p CKAFFKRsIQGHNDy
1 0 Y219-p sIQGHNDyMCPATNQ
5 1 S236-p IDKNRRKsCQACRLR
1 0 K244-ac CQACRLRkCyEVGMM
0 1 Y246-p ACRLRkCyEVGMMkG
1 0 K252-ac CyEVGMMkGGIRKDR
3 1 K266-ac RRGGRMLkHkRQRDD
1 0 K266-m1 RRGGRMLkHkRQRDD
1 0 K266-sm RRGGRMLkHkRQRDD
3 0 K268-ac GGRMLkHkRQRDDGE
1 0 K268-sm GGRMLkHkRQRDDGE
1 0 R277-m2 QRDDGEGrGEVGsAG
4 0 S282-p EGrGEVGsAGDMRAA
0 1 A283 GrGEVGsAGDMRAAN
9 1 S294-p RAANLWPsPLMIkRS
3 0 K299-ac WPsPLMIkRSkkNsL
1 0 K299-sm WPsPLMIkRSkkNsL
2 0 K302-ac PLMIkRSkkNsLALS
2 0 K302-m1 PLMIkRSkkNsLALS
2 0 K302-ub PLMIkRSkkNsLALS
5 0 K303-ac LMIkRSkkNsLALSL
14 0 S305-p IkRSkkNsLALSLtA
6 0 T311-p NsLALSLtADQMVSA
1 0 S341-p TRPFSEAsMMGLLTN
1 0 K401-m2 RSMEHPGkLLFAPNL
0 1 S450 EEFVCLKSIILLNSG
0 1 S464 GVYTFLSSTLKSLEE
1 1 K472-ac TLKSLEEkDHIHRVL
1 0 K472-sm TLKSLEEkDHIHRVL
0 1 T485-p VLDKITDtLIHLMAK
6 0 Y537-p CKNVVPLyDLLLEML
1 1 S554-p HRLHAPTsRGGAsVE
4 1 S559-p PTsRGGAsVEETDQS
2 0 A571 DQSHLATAGSTSsHs
1 0 S576-p ATAGSTSsHsLQKYY
1 0 S578-p AGSTSsHsLQKYYIT
1 0 T594-p EAEGFPAtV______
2517 : Phospho-Estrogen Receptor alpha (Ser104/106) Antibody
2517 : Phospho-Estrogen Receptor alpha (Ser104/106) Antibody
2511 : Phospho-Estrogen Receptor alpha (Ser118) (16J4) Mouse mAb
5587 : Phospho-Estrogen Receptor alpha (Ser167) (D1A3) Rabbit mAb
  mouse

 
T7 _MTMTLHTKAsGMAL
S10 MTLHTKASGMALLHQ
S10-gl MTLHTKAsGMALLHQ
K32 PLNRPQLKMPMERAL
N46 LGEVYVDNSKPtVFN
S47 GEVYVDNSKPtVFNY
T50-gl YVDNSKPtVFNYPEG
F52 DNSKPtVFNYPEGAA
S106 GAFPQLNSVSPSPLM
S108 FPQLNSVSPSPLMLL
S110 QLNSVSPSPLMLLHP
S122-p LHPPPQLsPFLHPHG
S156-p GPPAFYRsNsDNRRQ
S158-p PAFYRsNsDNRRQNG
S171-p NGRERLSsSNEKGNM
K175 RLSsSNEKGNMIMES
K175 RLSsSNEKGNMIMES
K175 RLSsSNEKGNMIMES
K175 RLSsSNEKGNMIMES
K184 NMIMESAKETRYCAV
K184 NMIMESAKETRYCAV
S216-p CKAFFKRsIQGHNDY
Y223 sIQGHNDYMCPATNQ
S240 IDKNRRKSCQACRLR
K248 CQACRLRKCYEVGMM
Y250 ACRLRKCYEVGMMKG
K256 CYEVGMMKGGIRKDR
K270 RRGGRMLKHKRQRDD
K270 RRGGRMLKHKRQRDD
K270 RRGGRMLKHKRQRDD
K272 GGRMLKHKRQRDDLE
K272 GGRMLKHKRQRDDLE
R281 QRDDLEGRNEMGAsG
A286 EGRNEMGAsGDMRAA
S287-p GRNEMGAsGDMRAAN
S298-p RAANLWPsPLVIKHT
K303 WPsPLVIKHTKKNSP
K303 WPsPLVIKHTKKNSP
K306 PLVIKHTKKNSPALS
K306 PLVIKHTKKNSPALS
K306 PLVIKHTKKNSPALS
K307 LVIKHTKKNSPALSL
S309 IKHTKKNSPALSLTA
T315 NSPALSLTADQMVSA
S345 SRPFSEASMMGLLTN
K405 RSMEHPGKLLFAPNL
S454 EEFVCLKSIILLNSG
S468 GVYTFLSSTLKSLEE
K476 TLKSLEEKDHIHRVL
K476 TLKSLEEKDHIHRVL
T489 VLDKITDTLIHLMAK
Y541 CKNVVPLYDLLLEML
S558 HRLHAPASRMGVPPE
P563 PASRMGVPPEEPSQT
T575-gl SQTQLATtSSTSAHS
A580 ATtSSTSAHSLQTYY
S582 tSSTSAHSLQTYYIP
T598 EAEGFPNTI______
2517 : Phospho-Estrogen Receptor alpha (Ser104/106) Antibody
2517 : Phospho-Estrogen Receptor alpha (Ser104/106) Antibody
2511 : Phospho-Estrogen Receptor alpha (Ser118) (16J4) Mouse mAb
  rat

 
T7 _MTMTLHTKASGMAL
S10 MTLHTKASGMALLHQ
S10 MTLHTKASGMALLHQ
K32 PLNRPQLKMPMERAL
N46 LGEVYVDNSKPAVFN
S47 GEVYVDNSKPAVFNY
A50 YVDNSKPAVFNYPEG
F52 DNSKPAVFNYPEGAA
S107 GAFPQLNSVSPSPLM
S109 FPQLNSVSPSPLMLL
S111 QLNSVSPSPLMLLHP
S123-p LHPPPHVsPFLHPHG
S157 GPPAFYRSNSDNRRQ
S159 PAFYRSNSDNRRQNG
S172 NGRERLSSSSEKGNM
K176 RLSSSSEKGNMIMES
K176 RLSSSSEKGNMIMES
K176 RLSSSSEKGNMIMES
K176 RLSSSSEKGNMIMES
K185 NMIMESAKETRYCAV
K185 NMIMESAKETRYCAV
S217 CKAFFKRSIQGHNDY
Y224 SIQGHNDYMCPATNQ
S241 IDKNRRKSCQACRLR
K249 CQACRLRKCyEVGMM
Y251-p ACRLRKCyEVGMMKG
K257 CyEVGMMKGGIRKDR
K271 RRGGRMLKHKRQRDD
K271 RRGGRMLKHKRQRDD
K271 RRGGRMLKHKRQRDD
K273 GGRMLKHKRQRDDLE
K273 GGRMLKHKRQRDDLE
R282 QRDDLEGRNEMGTSG
T287 EGRNEMGTSGDMRAA
S288 GRNEMGTSGDMRAAN
S299 RAANLWPSPLVIKHT
K304 WPSPLVIKHTKKNSP
K304 WPSPLVIKHTKKNSP
K307 PLVIKHTKKNSPALS
K307 PLVIKHTKKNSPALS
K307 PLVIKHTKKNSPALS
K308 LVIKHTKKNSPALSL
S310 IKHTKKNSPALSLTA
T316 NSPALSLTADQMVSA
S346 SRPFSEASMMGLLTN
K406 RSMEHPGKLLFAPNL
S455-p EEFVCLKsIILLNSG
S469-p GVYTFLSsTLKSLEE
K477 TLKSLEEKDHIHRVL
K477 TLKSLEEKDHIHRVL
T490 VLDKINDTLIHLMAK
Y542 CKNVVPLYDLLLEML
S559 HRLHAPASRMGVPPE
P564 PASRMGVPPEEPSQS
T576 SQSQLTTTSSTSAHS
A581 TTTSSTSAHSLQTYY
S583 TSSTSAHSLQTYYIP
T599 EAEGFPNTI______
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