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ER-alpha (human)

Overview ER-alpha a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Nuclear receptor Cellular Component: nucleoplasm; Golgi apparatus; chromatin remodeling complex; membrane; perinuclear region of cytoplasm; T-tubule; integral to membrane; plasma membrane; terminal button; perikaryon; nucleus Molecular Function: identical protein binding; estrogen receptor activity; hormone binding; type 1 metabotropic glutamate receptor binding; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; protein complex binding; steroid hormone receptor activity; chromatin binding; transcription factor activity Biological Process: positive regulation of nitric oxide biosynthetic process; estrogen receptor signaling pathway; signal transduction; uterus development; response to estradiol stimulus; regulation of apoptosis; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; positive regulation of epidermal growth factor receptor signaling pathway; epithelial cell development; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription factor activity; positive regulation of nitric-oxide synthase activity; antral ovarian follicle growth; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; Sertoli cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; osteoblast development; response to estrogen stimulus; positive regulation of transcription factor activity; gene expression; positive regulation of transcription from RNA polymerase II promoter Reference #:  P03372 (UniProtKB) Alt. Names/Synonyms: DKFZp686N23123; ER; ER-alpha; Era; ESR; ESR1; ESRA; Estradiol receptor; Estrogen receptor; estrogen receptor 1; estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform; estrogen receptor alpha delta 4 +49 isoform; estrogen receptor alpha delta 4*,5,6,7*/654 isoform; NR3A1; Nuclear receptor subfamily 3 group A member 1 Gene Symbols: ESR1 Molecular weight: 66,216 Da Basal Isoelectric point: 8.3  Predict pI for various phosphorylation states CST Pathways:  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ER-alpha 1A52 - A/B=297-554 (human) 1AKF - A=309-547 (human) 1ERE - A/B/C/D/E/F=301-553 (human) 1ERR - A/B=301-553 (human) 1G50 - A/B/C=304-550 (human) 1GWQ - A/B=301-548 (human) 1GWR - A/B=305-549 (human) 1HCP - A=180-254 (human) 1HCQ - A/B/E/F=180-262 (human) 1L2I - A/B=297-554 (human) 1PCG - A/B=304-547 (human) 1QKT - A=304-551 (human) 1QKU - A/B/C=301-550 (human) 1R5K - A/B/C=297-554 (human) 1SJ0 - A=307-554 (human) 1UOM - A=301-553 (human) 1X7E - A/B=305-549 (human) 1X7R - A=305-549 (human) 1XP1 - A=307-554 (human) 1XP6 - A=307-554 (human) 1XP9 - A=307-554 (human) 1XPC - A=307-554 (human) 1XQC - A/B/C/D=301-553 (human) 1YIM - A=307-554 (human) 1YIN - A=307-554 (human) 1ZKY - A/B=298-554 (human) 2AYR - A=304-551 (human) 2B1V - A/B=298-554 (human) 2B1Z - A/B=298-554 (human) 2B23 - A/B=298-554 (human) 2BJ4 - A/B=304-533 (human) 2FAI - A/B=298-554 (human) 2G44 - A/B=298-554 (human) 2G5O - A/B=298-554 (human) 2I0J - A/B/C/D=304-547 (human) 2IOG - A=309-554 (human) 2IOK - A/B=301-554 (human) 2JF9 - A/B/C=303-533 (human) 2JFA - A/B=303-533 (human) 2LLO - B=287-305 (human) 2LLQ - B=287-305 (human) 2OCF - A=298-595 (human) 2OUZ - A=301-553 (human) 2P15 - A/B=298-554 (human) 2POG - A/B=304-551 (human) 2Q6J - A/B=298-554 (human) 2Q70 - A/B=304-551 (human) 2QA6 - A/B=298-554 (human) 2QA8 - A/B=298-554 (human) 2QAB - A/B=298-554 (human) 2QE4 - A/B=304-551 (human) 2QGT - A/B=298-554 (human) 2QGW - A/B=298-554 (human) 2QH6 - A/B=298-554 (human) 2QR9 - A/B=298-554 (human) 2QSE - A/B=298-554 (human) 2QXM - A/B=298-554 (human) 2QXS - A/B=298-554 (human) 2QZO - A/B=298-554 (human) 2R6W - A/B=304-551 (human) 2R6Y - A/B=304-551 (human) 2YAT - A=301-551 (human) 2YJA - B=299-551 (human) 3CBM - B=298-307 (human) 3CBO - B=298-307 (human) 3CBP - B=298-307 (human) 3DT3 - A/B=299-551 (human) 3ERD - A/B=297-554 (human) 3ERT - A=297-554 (human) 3HLV - A/B=298-550 (human) 3HM1 - A/B=298-550 (human) 3L03 - A/B=298-550 (human) 3OS8 - A/D/C/B=299-553 (human) 3OS9 - A/D/C/B=299-553 (human) 3OSA - A/D/C/B=299-553 (human) 3Q95 - A/B=298-554 (human) 3Q97 - A/B=298-554 (human) 3UU7 - F/G=686-698 (human) 3UUA - F/G=686-698 (human) 3UUC - A/D/C/B=302-552 (human) 3UUD - D/C=686-698 (human) 4AA6 - F/A/E/B=182-252 (human) 4DMA - A/B=303-549 (human) 4IU7 - D/C=687-696 (human) 4IUI - D/C=687-696 (human) 4IV2 - D/C=687-696 (human) 4IV4 - D/C=687-696 (human) 4IVW - D/C=687-696 (human) 4IVY - D/C=687-696 (human) 4IW6 - D/C=687-696 (human) 4IW8 - D/C=687-696 (human) 4IWC - D/C=687-696 (human) 4IWF - D/C=687-696 (human) 4JC3 - B=585-595 (human) 4JDD - B=585-595 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2LLO 2LLQ 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 2YAT 2YJA 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT 3HLV 3HM1 3L03 3OS8 3OS9 3OSA 3Q95 3Q97 3UU7 3UUA 3UUC 3UUD 4AA6 4DMA 4IU7 4IUI 4IV2 4IV4 4IVW 4IVY 4IW6 4IW8 4IWC 4IWF 4JC3 4JDD  |  Phospho3D  |  DISEASE 133430 157300 608446  |  Source  |  NURSA  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
apoptosis, inhibited: S167‑p carcinogenesis, altered: S118‑p, S305‑p carcinogenesis, induced: Y52‑p, Y219‑p cell growth, altered: Y52‑p, S118‑p, S167‑p, Y219‑p, S305‑p transcription, altered: S46‑p, S47‑p, Y52‑p, S104‑p, S106‑p, S118‑p, S167‑p, Y219‑p, S236‑p, K266‑a, K268‑a, S282‑p, S294‑p, K302‑u, K302‑a, K303‑a, S305‑p, T311‑p, Y537‑p, S559‑p transcription, induced: S102‑p, S104‑p, S106‑p, S118‑p, S305‑p acetylation: S118‑p, S167‑p activation: S46‑p, S47‑p, S102‑p, S104‑p, S106‑p, S118‑p, S167‑p, K266‑a, K268‑a, S294‑p, K302‑a, K303‑a, S305‑p, T311‑p inhibition: S282‑p, K302‑u, K303‑a, S559‑p intracellular localization: S305‑p, T311‑p molecular association, regulation: S104‑p, S106‑p, S118‑p, S167‑p, Y219‑p, K266‑a, K268‑a, S305‑p, T311‑p, Y537‑p phosphorylation: S118‑p, S305‑p protein conformation: S305‑p protein degradation: S118‑p protein stabilization: Y52‑p, Y219‑p, Y537‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T2-p	______MtMtLHtKA
0	1		T4-p	____MtMtLHtKAsG
0	1		T7-p	_MtMtLHtKAsGMAL
0	1		S10-p	MtLHtKAsGMALLHQ
1	0		S10	MtLHtKASGMALLHQ
1	0		S46-p	LGEVYLDssKPAVyN
1	0		S47-p	GEVYLDssKPAVyNY
1	0		A50	YLDssKPAVyNYPEG
1	0		Y52-p	DssKPAVyNYPEGAA
3	1		S102-p	GGFPPLNsVsPsPLM
18	1		S104-p	FPPLNsVsPsPLMLL
18	1		S106-p	PLNsVsPsPLMLLHP
72	2		S118-p	LHPPPQLsPFLQPHG
1	0		P152	GPPAFYRPNsDNRRQ
3	2		S154-p	PAFYRPNsDNRRQGG
31	3		S167-p	GGRERLAsTNDKGSM
2	1		S212-p	CKAFFKRsIQGHNDy
1	0		Y219-p	sIQGHNDyMCPATNQ
5	1		S236-p	IDKNRRKsCQACRLR
1	0		K244-a	CQACRLRkCYEVGMM
0	1		Y246	ACRLRkCYEVGMMkG
1	0		K252-a	CYEVGMMkGGIRKDR
2	1		K266-a	RRGGRMLkHkRQRDD
1	0		K266-s	RRGGRMLkHkRQRDD
2	0		K268-a	GGRMLkHkRQRDDGE
1	0		K268-s	GGRMLkHkRQRDDGE
3	0		S282-p	EGRGEVGsAGDMRAA
0	1		A283	GRGEVGsAGDMRAAN
7	1		S294-p	RAANLWPsPLMIkRS
2	0		K299-a	WPsPLMIkRSkkNsL
2	0		K302-a	PLMIkRSkkNsLALS
2	0		K302-m1	PLMIkRSkkNsLALS
2	0		K302-u	PLMIkRSkkNsLALS
4	0		K303-a	LMIkRSkkNsLALSL
12	0		S305-p	IkRSkkNsLALSLtA
6	0		T311-p	NsLALSLtADQMVSA
0	1		S450	EEFVCLKSIILLNSG
0	1		S464	GVYTFLSSTLKSLEE
1	1		K472-a	TLKSLEEkDHIHRVL
0	1		T485-p	VLDKITDtLIHLMAK
6	0		Y537-p	CKNVVPLyDLLLEML
1	1		S554-p	HRLHAPTsRGGAsVE
4	1		S559-p	PTsRGGAsVEETDQS
2	0		A571	DQSHLATAGSTSSHS

	mouse
T2	______MTMTLHTKA
T4	____MTMTLHTKAsG
T7	_MTMTLHTKAsGMAL
S10	MTLHTKASGMALLHQ
S10-gl	MTLHTKAsGMALLHQ
N46	LGEVYVDNSKPtVFN
S47	GEVYVDNSKPtVFNY
T50-gl	YVDNSKPtVFNYPEG
F52	DNSKPtVFNYPEGAA
S106	GAFPQLNSVSPSPLM
S108	FPQLNSVSPSPLMLL
S110	QLNSVSPSPLMLLHP
S122-p	LHPPPQLsPFLHPHG
S156-p	GPPAFYRsNsDNRRQ
S158-p	PAFYRsNsDNRRQNG
S171-p	NGRERLSsSNEKGNM
S216	CKAFFKRSIQGHNDY
Y223	SIQGHNDYMCPATNQ
S240	IDKNRRKSCQACRLR
K248	CQACRLRKCYEVGMM
Y250	ACRLRKCYEVGMMKG
K256	CYEVGMMKGGIRKDR
K270	RRGGRMLKHKRQRDD
K270	RRGGRMLKHKRQRDD
K272	GGRMLKHKRQRDDLE
K272	GGRMLKHKRQRDDLE
A286	EGRNEMGAsGDMRAA
S287-p	GRNEMGAsGDMRAAN
S298-p	RAANLWPsPLVIKHT
K303	WPsPLVIKHTKKNSP
K306	PLVIKHTKKNSPALS
K306	PLVIKHTKKNSPALS
K306	PLVIKHTKKNSPALS
K307	LVIKHTKKNSPALSL
S309	IKHTKKNSPALSLTA
T315	NSPALSLTADQMVSA
S454	EEFVCLKSIILLNSG
S468	GVYTFLSSTLKSLEE
K476	TLKSLEEKDHIHRVL
T489	VLDKITDTLIHLMAK
Y541	CKNVVPLYDLLLEML
S558	HRLHAPASRMGVPPE
P563	PASRMGVPPEEPSQT
T575-gl	SQTQLATtSSTSAHS

	rat
T2	______MTMTLHTKA
T4	____MTMTLHTKASG
T7	_MTMTLHTKASGMAL
S10	MTLHTKASGMALLHQ
S10	MTLHTKASGMALLHQ
N46	LGEVYVDNSKPAVFN
S47	GEVYVDNSKPAVFNY
A50	YVDNSKPAVFNYPEG
F52	DNSKPAVFNYPEGAA
S107	GAFPQLNSVSPSPLM
S109	FPQLNSVSPSPLMLL
S111	QLNSVSPSPLMLLHP
S123-p	LHPPPHVsPFLHPHG
S157	GPPAFYRSNSDNRRQ
S159	PAFYRSNSDNRRQNG
S172	NGRERLSSSSEKGNM
S217	CKAFFKRSIQGHNDY
Y224	SIQGHNDYMCPATNQ
S241	IDKNRRKSCQACRLR
K249	CQACRLRKCyEVGMM
Y251-p	ACRLRKCyEVGMMKG
K257	CyEVGMMKGGIRKDR
K271	RRGGRMLKHKRQRDD
K271	RRGGRMLKHKRQRDD
K273	GGRMLKHKRQRDDLE
K273	GGRMLKHKRQRDDLE
T287	EGRNEMGTSGDMRAA
S288	GRNEMGTSGDMRAAN
S299	RAANLWPSPLVIKHT
K304	WPSPLVIKHTKKNSP
K307	PLVIKHTKKNSPALS
K307	PLVIKHTKKNSPALS
K307	PLVIKHTKKNSPALS
K308	LVIKHTKKNSPALSL
S310	IKHTKKNSPALSLTA
T316	NSPALSLTADQMVSA
S455-p	EEFVCLKsIILLNSG
S469-p	GVYTFLSsTLKSLEE
K477	TLKSLEEKDHIHRVL
T490	VLDKINDTLIHLMAK
Y542	CKNVVPLYDLLLEML
S559	HRLHAPASRMGVPPE
P564	PASRMGVPPEEPSQS
T576	SQSQLTTTSSTSAHS

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