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Protein Page:
IQGAP2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IQGAP2 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; G protein regulator, misc.
Cellular Component: microtubule; microvillus; actin cytoskeleton
Molecular Function: calmodulin binding; phosphatidylinositol-3,4,5-triphosphate binding; actin binding; Ras GTPase activator activity; GTPase inhibitor activity
Biological Process: positive regulation of Ras GTPase activity; small GTPase mediated signal transduction; negative regulation of catalytic activity; signal transduction
Reference #:  Q13576 (UniProtKB)
Alt. Names/Synonyms: IQ motif containing GTPase activating protein 2; IQGA2; IQGAP2; Ras GTPase-activating-like protein IQGAP2
Gene Symbols: IQGAP2
Molecular weight: 180,578 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IQGAP2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 6 Y14-p PSLQRPRyGsIVDDE
0 119 S16-p LQRPRyGsIVDDERL
0 1 S24-p IVDDERLsAEEMDER
0 4 Y38-p RRRQNIAyEYLCHLE
0 3 K77-ub RNGVYLAkLAKFFAP
0 1 K80 VYLAkLAKFFAPKMV
0 1 K85 LAKFFAPKMVSEKkI
0 4 K91-ub PKMVSEKkIyDVEQT
0 45 Y93-p MVSEKkIyDVEQTRY
0 1 S103-p EQTRYKKsGLHFRHT
0 2 S122-p QWLRAMEsIGLPKIF
0 1 K127 MEsIGLPKIFYPETT
0 4 Y137-p YPETTDVyDRKNIPR
0 4 K171-ub QIQDLLGkVDFTEEE
0 1 R183 EEEISNMRKELEKyG
0 1 Y189-p MRKELEKyGIQMPsF
0 1 S195-p KyGIQMPsFsKIGGI
0 1 S197-p GIQMPsFsKIGGILA
0 1 E231 AVEKGIAEQTVVTLR
0 1 K257 NLAPEYQKELWDAKK
0 1 Y285-p SEEERDAyEELLTQA
0 1 T356-p FNLQKQNtMNYLAHE
0 1 S432-p SQGQDNLsWNEIQNC
0 2 Y494-p DPAHAQHyQDVLyHA
0 4 Y499-p QHyQDVLyHAKSQKL
0 1 K552 VNQCLEGKKSSDILS
0 2 S554 QCLEGKKSSDILSVL
0 1 K578 IIPECADKyyDALVK
0 4 Y579-p IPECADKyyDALVKA
0 3 Y580-p PECADKyyDALVKAK
0 1 K585 KyyDALVKAKELksE
0 2 K590-ub LVKAKELksERVssD
0 1 S591-p VKAKELksERVssDG
0 2 S595-p ELksERVssDGsWLK
0 1 S596-p LksERVssDGsWLKL
0 1 S599-p ERVssDGsWLKLNLH
0 3 Y609-p KLNLHKKyDyyyNTD
0 11 Y611-p NLHKKyDyyyNTDsK
0 8 Y612-p LHKKyDyyyNTDsKE
0 3 Y613-p HKKyDyyyNTDsKES
0 1 S617-p DyyyNTDsKESSWVt
0 1 T624-p sKESSWVtPESCLyK
0 4 Y630-p VtPESCLyKESWLTG
0 1 S658 YIRENIWSASEELLL
0 1 S671-p LLRFQATssGPILRE
0 1 S672-p LRFQATssGPILREE
0 3 S685-p EEFEARKsFLHEQEE
0 1 Y710-p GYKQRKEyMHRRQtF
2 1 T716-p EyMHRRQtFIDNTDS
0 6 T735-p QSWFRMAtARKsyLS
0 6 S739-p RMAtARKsyLSRLQy
0 2 Y740-p MAtARKsyLSRLQyF
0 19 Y746-p syLSRLQyFRDHNNE
0 1 K756 DHNNEIVKIQsLLRA
0 5 S759-p NEIVKIQsLLRANKA
0 2 N764 IQsLLRANKARDDyk
0 35 Y770-p ANKARDDyktLVGSE
0 1 K771-ac NKARDDyktLVGSEN
0 1 K771 NKARDDyKtLVGSEN
0 2 T772-p KARDDyktLVGSENP
0 1 T782-p GSENPPLtVIRkFVY
0 1 K786-ac PPLtVIRkFVYLLDQ
0 3 K814-ub LREEVVTkIRANQQL
0 1 K823 RANQQLEKDLNLMDI
0 1 K823 RANQQLEKDLNLMDI
0 1 Q869 ILNNTDNQGIKSLSK
0 1 K880 SLSKERRKtLETyQQ
0 16 T881-p LSKERRKtLETyQQL
0 1 Y885-p RRKtLETyQQLFyLL
0 1 Y890-p ETyQQLFyLLQTNPL
0 1 K940 YLLLKLFKTALEEEI
0 1 K940 YLLLKLFKTALEEEI
0 1 K950 LEEEIKSKVDQVQDI
0 2 S970-p TVIKMVVsFNRGARG
0 1 K990 QLLAPVVKEIIDDKS
0 1 K996 VKEIIDDKSLIINtN
0 1 K996 VKEIIDDKSLIINtN
0 1 T1002-p DKSLIINtNPVEVYK
0 2 K1024 TQTGEASKLPYDVTT
0 1 K1041 ALTYPEVKNKLEASI
0 1 K1043 TYPEVKNKLEASIEN
0 15 Y1106-p IVGNLLYyRYMNPAI
0 1 Y1172-p NNYLSETyQEFRKYF
0 1 K1177 ETyQEFRKYFKEACN
0 1 K1196 EEKFNMDKYTDLVTV
0 1 T1249-p GSLGEVPtVESFLGE
0 1 T1269-p NDPNKANtLsQLSKt
0 1 S1271-p PNKANtLsQLSKtEI
0 1 T1276-p tLsQLSKtEIsLVLT
0 1 S1279-p QLSKtEIsLVLTsKY
0 1 S1284-p EIsLVLTsKYDIEDG
0 1 E1289 LTsKYDIEDGEAIDS
0 1 K1305 SLMIKTKKLIIDVIR
0 1 T1337 QQEVDHATDMVSRAM
0 2 T1349-p RAMIDSRtPEEMKHs
0 2 K1354 SRtPEEMKHsQsMIE
0 4 S1356-p tPEEMKHsQsMIEDA
0 4 S1358-p EEMKHsQsMIEDAQL
0 1 S1389 EQTGHVSSENKyQDI
0 1 K1392 GHVSSENKyQDILNE
0 3 Y1393-p HVSSENKyQDILNEI
0 1 K1402 DILNEIAKDIRNQRI
0 1 K1402 DILNEIAKDIRNQRI
0 1 K1420 LRKAELAKLQQTLNA
0 1 K1420 LRKAELAKLQQTLNA
0 1 K1430 QTLNALNKKAAFYEE
0 1 K1431 TLNALNKKAAFYEEQ
0 1 K1454 KTCLDNLKRKNTRRs
0 3 T1458 DNLKRKNTRRsIKLD
0 11 S1461-p KRKNTRRsIKLDGkG
0 6 K1467-ac RsIKLDGkGEPkGAk
0 7 K1471-ac LDGkGEPkGAkRAKP
0 6 K1474-ac kGEPkGAkRAKPVKY
0 1 K1489 TAAKLHEKGVLLDID
0 1 T1513 VTFDIIATEDVGIFD
0 1 K1524 GIFDVRSKFLGVEME
  IQGAP2 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
Y47 DPAHAQHYQDVLYHA
Y52 QHYQDVLYHAKSQKL
K105 VNQCLEGKKSSDILS
S107 QCLEGKKSSDILSVL
K131 IIPECADKYYDALVK
Y132 IPECADKYYDALVKA
Y133 PECADKYYDALVKAK
K138 KYYDALVKAKELKSE
K143 LVKAKELKSERVSSD
S144 VKAKELKSERVSSDG
S148 ELKSERVSSDGSWLK
S149 LKSERVSSDGSWLKL
S152 ERVSSDGSWLKLNLH
Y162 KLNLHKKYDYYYNTD
Y164 NLHKKYDYYYNTDSK
Y165 LHKKYDYYYNTDSKE
Y166 HKKYDYYYNTDSKES
S170 DYYYNTDSKESSWVT
T177 SKESSWVTPESCLYK
Y183 VTPESCLYKESWLTG
- gap
- gap
- gap
- gap
Y206 GYKQRKEYMHRRQTF
T212 EYMHRRQTFIDNTDS
T231 QSWFRMATARKSYLS
S235 RMATARKSYLSRLQY
Y236 MATARKSYLSRLQYF
Y242 SYLSRLQYFRDHNNE
K252 DHNNEIVKIQSLLRA
S255 NEIVKIQSLLRANKA
N260 IQSLLRANKARDDYK
Y266 ANKARDDYKTLVGSE
K267 NKARDDYKTLVGSEN
K267 NKARDDYKTLVGSEN
T268 KARDDYKTLVGSENP
T278 GSENPPLTVIRKFVY
K282 PPLTVIRKFVYLLDQ
K310 LREEVVTKIRANQQL
K319 RANQQLEKDLNLMDI
K319 RANQQLEKDLNLMDI
Q365 ILNNTDNQGIKSLSK
K376 SLSKERRKTLETYQQ
T377 LSKERRKTLETYQQL
Y381 RRKTLETYQQLFYLL
Y386 ETYQQLFYLLQTNPL
K436 YLLLKLFKTALEEEI
K436 YLLLKLFKTALEEEI
K446 LEEEIKSKVDQVQDI
S466 TVIKMVVSFNRGARG
K486 QLLAPVVKEIIDDKS
K492 VKEIIDDKSLIINTN
K492 VKEIIDDKSLIINTN
T498 DKSLIINTNPVEVYK
K520 TQTGEASKLPYDVTT
K537 ALTYPEVKNKLEASI
K539 TYPEVKNKLEASIEN
Y602 IVGNLLYYRYMNPAI
Y668 NNYLSETYQEFRKYF
K673 ETYQEFRKYFKEACN
K692 EEKFNMDKYTDLVTV
T745 GSLGEVPTVESFLGE
T765 NDPNKANTLSQLSKT
S767 PNKANTLSQLSKTEI
T772 TLSQLSKTEISLVLT
S775 QLSKTEISLVLTSKY
S780 EISLVLTSKYDIEDG
E785 LTSKYDIEDGEAIDS
K801 SLMIKTKKLIIDVIR
T833 QQEVDHATDMVSRAM
T845 RAMIDSRTPEEMKHS
K850 SRTPEEMKHSQSMIE
S852 TPEEMKHSQSMIEDA
S854 EEMKHSQSMIEDAQL
S885 EQTGHVSSENKYQDI
K888 GHVSSENKYQDILNE
Y889 HVSSENKYQDILNEI
K898 DILNEIAKDIRNQRI
K898 DILNEIAKDIRNQRI
K916 LRKAELAKLQQTLNA
K916 LRKAELAKLQQTLNA
K926 QTLNALNKKAAFYEE
K927 TLNALNKKAAFYEEQ
K950 KTCLDNLKRKNTRRS
T954 DNLKRKNTRRSIKLD
S957 KRKNTRRSIKLDGKG
K963 RSIKLDGKGEPKGAK
K967 LDGKGEPKGAKRAKP
K970 KGEPKGAKRAKPVKY
K985 TAAKLHEKGVLLDID
T1009 VTFDIIATEDVGIFD
K1020 GIFDVRSKFLGVEME
  mouse

 
Y14-p PSLQRPRyGsIVDDE
S16-p LQRPRyGsIVDDERL
S24 IVDDERLSAEEMDER
Y38 RRRQNIAYEYLCHLE
K77 RNGVYLAKLAkFFAP
K80-ub VYLAKLAkFFAPkMV
K85-ub LAkFFAPkMVSEKKI
K91 PkMVSEKKIyDVEQT
Y93-p MVSEKKIyDVEQTRY
S103 EQTRYKKSGLHFRHT
A122 QWLRAMEAIGLPkIF
K127-ub MEAIGLPkIFYPETT
Y137 YPETTDVYDRKNIPR
K171 QIQDLLGKVDFTEEE
R183-m2 EEEISNMrKELEKYG
Y189 MrKELEKYGIQMPAF
A195 KYGIQMPAFSKIGGI
S197 GIQMPAFSKIGGILA
K231-ub AIEKGVAkQTIITLR
K257-ub SLSQEYQkELWEAKK
Y285-p SEEERDAyEELLTQA
T356 FNLQKQNTSNYLAHE
S432 SQGQDTLSWNEIQNC
Y494 DPDCAQHYQDVLFYT
F499 QHYQDVLFYTKSQKL
K552-ub VNECLDRkQsDHILT
S554-p ECLDRkQsDHILTAL
K578-ub ILPECANkYYDTLVk
Y579 LPECANkYYDTLVkA
Y580 PECANkYYDTLVkAK
K585-ub kYYDTLVkAKESKTD
K590 LVkAKESKTDNESSE
T591 VkAKESKTDNESSEG
S595 ESKTDNESSEGSWVT
S596 SKTDNESSEGSWVTL
S599 DNESSEGSWVTLNVQ
Y609 TLNVQEKYNYYYNTD
Y611 NVQEKYNYYYNTDSK
Y612 VQEKYNYYYNTDSKE
Y613 QEKYNYYYNTDSKEG
S617 NYYYNTDSKEGSWVP
P624 SKEGSWVPPELCLSK
S630 VPPELCLSKESWLTG
S658-p YIREKLWsASEDLLV
T671 LVRFEATTLGPALRE
L672 VRFEATTLGPALREE
A685 EEFEARKAFLYEQTE
Y710 GFKQRQEYLHRQQVF
V716 EYLHRQQVFAGNVDS
T735 QSWFRMVTARKSYLS
S739 RMVTARKSYLSRLRY
Y740 MVTARKSYLSRLRYF
Y746 SYLSRLRYFEDHKNE
K756-ub DHKNEIVkIQsLLRA
S759-p NEIVkIQsLLRAsKA
S764-p IQsLLRAsKARDDYk
Y770 AsKARDDYkALVGSE
K771 sKARDDYKALVGSEN
K771-ub sKARDDYkALVGSEN
A772 KARDDYkALVGSENP
T782 GSENPPLTVIRKFVY
K786 PPLTVIRKFVYLLDQ
K814-ub LREEVVTkIRANQQL
K823-ac RANQQLEkDLNLMDI
K823-ub RANQQLEkDLNLMDI
K869-ub ILNNTDNkGIKSLSK
K880-ub SLSKERRktLETYQQ
T881-p LSKERRktLETYQQL
Y885 RRktLETYQQLFYLL
Y890 ETYQQLFYLLQTKPS
K940-ac YLLLKLFkTALEEEI
K940-ub YLLLKLFkTALEEEI
K950-ub LEEEIKSkVDQVQDI
S970-p TVIKMVVsFNRGARG
K990-ub QLLAPVVkEIIEDkA
K996-ac VkEIIEDkALVINTN
K996-ub VkEIIEDkALVINTN
T1002 DkALVINTNPVEVYK
K1024-ub TQTGEASkLPYDVTT
K1041-ub ALTYPEVkNkLEASI
K1043-ub TYPEVkNkLEASIEN
Y1106-p IVGNLLYyRYMNPAI
Y1172 NNYLSETYQEFRkYF
K1177-ub ETYQEFRkYFQEACD
K1196-ac EEKFNMDkYTDLVTV
T1249 ESLGEVPTVESFLGE
T1269 NDPNKENTLNQLSKT
N1271 PNKENTLNQLSKTEI
T1276 TLNQLSKTEISLSLT
S1279 QLSKTEISLSLTSKY
S1284 EISLSLTSKYDVkDG
K1289-ub LTSKYDVkDGEAVDG
K1305-ub SLMIKTKkLIIDVTR
K1337-ub QQELEHAkDMESRAV
T1349 RAVVDSRTPEEGkQS
K1354-ub SRTPEEGkQSQAVIE
S1356 TPEEGkQSQAVIEDA
A1358 EEGkQSQAVIEDARL
S1389-p EQTGHVSsKNkYQDI
K1392-ub GHVSsKNkYQDILNE
Y1393 HVSsKNkYQDILNEI
K1402-ac DILNEIAkDIRNQRI
K1402-ub DILNEIAkDIRNQRI
K1420-ac LRKAELSkLQQTLNA
K1420-ub LRKAELSkLQQTLNA
K1430-ub QTLNALNkkAAFYED
K1431-ub TLNALNkkAAFYEDQ
K1454-ub KTCVDNLkRKNsRRs
S1458-p DNLkRKNsRRsIKLD
S1461-p kRKNsRRsIKLDGKA
K1467 RsIKLDGKAEPKGTK
K1471 LDGKAEPKGTKRVKP
K1474 KAEPKGTKRVKPVRY
K1489-ub TAAKLHDkGVLLGID
T1513-p VMFDIIAtEDMGIFD
K1524-ub GIFDVRSkFLGVEME
  rat

 
Y14 PSLQRPRYGsIVDDE
S16-p LQRPRYGsIVDDERL
S24 IVDDERLSAEEMDER
Y38 RRRQNIAYEYLCHLE
K77 RNGVYLAKLAKFFAP
K80 VYLAKLAKFFAPKVV
K85 LAKFFAPKVVSEKKI
K91 PKVVSEKKIyDVEQS
Y93-p VVSEKKIyDVEQSRY
S103 EQSRYKKSGLHFRHT
A122 QWLRAMEAIGLPKIF
K127 MEAIGLPKIFYPETT
Y137 YPETTDVYDRKNIPR
K171 QIQDLLGKVDFTEEE
R183 EEEISNMRKELEKYG
Y189 MRKELEKYGIQMPAF
A195 KYGIQMPAFSKIGGI
S197 GIQMPAFSKIGGILA
K231 AIEKGVAKQTIITLR
K257 SLSQEYQKELWEAKK
Y285 SEEERDAYEELLTQA
T356 FNLQKQNTSNYLAHE
S432 SQGQDTLSWNEIQNC
Y494 DPDCAHHYQDVLFHT
F499 HHYQDVLFHTKSQKL
K552 VNECLDRKQsDDILT
S554-p ECLDRKQsDDILTVL
K578 ILPECANKYFDTLMK
Y579 LPECANKYFDTLMKA
F580 PECANKYFDTLMKAK
K585 KYFDTLMKAKESKTD
K590 LMKAKESKTDGEPTE
T591 MKAKESKTDGEPTEG
P595 ESKTDGEPTEGPWVK
T596 SKTDGEPTEGPWVKL
P599 DGEPTEGPWVKLDVQ
Y609 KLDVQQKYNYYYNTD
Y611 DVQQKYNYYYNTDSK
Y612 VQQKYNYYYNTDSKE
Y613 QQKYNYYYNTDSKEG
S617 NYYYNTDSKEGSWIP
P624 SKEGSWIPPESCLCK
C630 IPPESCLCKESWLTG
S658 YIRENLWSASEDLLL
N671 LLRFEATNSGPILRE
S672 LRFEATNSGPILREE
A685 EEFEARKAFLYKQVG
Y710 GYKQRQEYLHRQQVF
V716 EYLHRQQVFARNVDS
T735 QSWFRMVTARKSYLS
S739 RMVTARKSYLSRLQY
Y740 MVTARKSYLSRLQYF
Y746 SYLSRLQYFEDHENE
K756 DHENEIVKIQsLLRA
S759-p NEIVKIQsLLRAsKA
S764-p IQsLLRAsKARDDYK
Y770 AsKARDDYKALVGSE
K771 sKARDDYKALVGSEN
K771 sKARDDYKALVGSEN
A772 KARDDYKALVGSENP
T782 GSENPPLTVIRKFVY
K786 PPLTVIRKFVYLLDQ
K814 LREEVVTKIRANQQL
K823-ac RANQQLEkDLNLMDI
K823 RANQQLEKDLNLMDI
Q869 ILTNTDNQGIKSLSK
K880 SLSKERRKtLETYQQ
T881-p LSKERRKtLETYQQL
Y885 RRKtLETYQQLFYLL
Y890 ETYQQLFYLLQTKPS
K940 YLLLKLFKTALEEEI
K940 YLLLKLFKTALEEEI
K950 LEEEIKSKVDQVQDI
S970-p TVIKMVVsFNRGARG
K990 QLLAPVVKEIIEDKA
K996 VKEIIEDKALIINTN
K996 VKEIIEDKALIINTN
T1002 DKALIINTNPVEVYK
K1024 TQTGEASKLPYDVTT
K1041 ALTYPEVKNKLEASI
K1043 TYPEVKNKLEASIEN
Y1106 IVGNLLYYRYMNPAI
Y1172 NNYLSETYQEFRKYF
K1177 ETYQEFRKYFQEACD
K1196 EEKFNMDKYTDLVTV
T1249 ESLGEVPTVESFLGE
T1269 NDPNKENTLNQLSKT
N1271 PNKENTLNQLSKTEI
T1276 TLNQLSKTEISLSLT
S1279 QLSKTEISLSLTSKY
S1284 EISLSLTSKYDVKDG
K1289 LTSKYDVKDGEAIDG
K1305 SLMIKTKKLIIDVVR
K1337 QQELEHTKDMESRAV
A1349 RAVADSRALEEGKQS
K1354 SRALEEGKQSQAVIE
S1356 ALEEGKQSQAVIEDA
A1358 EEGKQSQAVIEDASL
S1389 EQTGHVSSKNKYQDI
K1392 GHVSSKNKYQDILNE
Y1393 HVSSKNKYQDILNEI
K1402-ac DILNEIAkDIRNQRI
K1402 DILNEIAKDIRNQRI
K1420 LRKAELSKLQQTLNA
K1420 LRKAELSKLQQTLNA
K1430 QTLNALNKKAAFYED
K1431 TLNALNKKAAFYEDQ
K1454 KTCVDNLKRKNSRRS
S1458 DNLKRKNSRRSIKLD
S1461 KRKNSRRSIKLDGKA
K1467 RSIKLDGKAEPKGTK
K1471 LDGKAEPKGTKRVKP
K1474 KAEPKGTKRVKPVRY
K1489 TAAKLHDKGVLLGID
T1513 VMFDIIATEDMGIFD
K1524 GIFDVRSKFLGVEME
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