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IQGAP2 (human)

Overview IQGAP2 Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin. Isoform 2 expression is enhanced in testis. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; G protein regulator, misc. Cellular Component: microtubule; microvillus; actin cytoskeleton Molecular Function: calmodulin binding; actin binding; Ras GTPase activator activity; GTPase inhibitor activity Biological Process: small GTPase mediated signal transduction; signal transduction Reference #:  Q13576 (UniProtKB) Alt. Names/Synonyms: IQ motif containing GTPase activating protein 2; IQGA2; IQGAP2; Ras GTPase-activating-like protein IQGAP2 Gene Symbols: IQGAP2 Molecular weight: 180,578 Da Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states CST Pathways:  Adherens Junction Dynamics Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IQGAP2 3IEZ - A/B=1476-1571 (human) 4EZA - A/B=1476-1571 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3IEZ 4EZA  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	5		Y14-p	PSLQRPRyGsIVDDE
0	98		S16-p	LQRPRyGsIVDDERL
0	1		S24-p	IVDDERLsAEEMDER
0	4		Y38-p	RRRQNIAyEYLCHLE
0	3		K77-u	RNGVYLAkLAKFFAP
0	1		K80	VYLAkLAKFFAPKMV
0	1		K85	LAKFFAPKMVSEKkI
0	4		K91-u	PKMVSEKkIyDVEQT
0	41		Y93-p	MVSEKkIyDVEQTRY
0	1		S122-p	QWLRAMEsIGLPKIF
0	1		K127	MEsIGLPKIFYPETT
0	4		Y137-p	YPETTDVyDRKNIPR
0	4		K171-u	QIQDLLGkVDFTEEE
0	1		Y189-p	MRKELEKyGIQMPsF
0	1		S195-p	KyGIQMPsFsKIGGI
0	1		S197-p	GIQMPsFsKIGGILA
0	1		E231	AVEKGIAEQTVVTLR
0	1		Y255-p	DDNLAPEyQKELWDA
0	1		K257	NLAPEyQKELWDAKK
0	1		Y285-p	SEEERDAyEELLTQA
0	2		Y494-p	DPAHAQHyQDVLyHA
0	4		Y499-p	QHyQDVLyHAKSQKL
0	1		K552	VNQCLEGKKSSDILS
0	1		S554	QCLEGKKSSDILSVL
0	1		K578	IIPECADKyyDALVK
0	4		Y579-p	IPECADKyyDALVKA
0	3		Y580-p	PECADKyyDALVKAK
0	1		K585	KyyDALVKAKELksE
0	2		K590-u	LVKAKELksERVssD
0	1		S591-p	VKAKELksERVssDG
0	1		S595-p	ELksERVssDGSWLK
0	1		S596-p	LksERVssDGSWLKL
0	2		Y609-p	KLNLHKKyDyyyNTD
0	10		Y611-p	NLHKKyDyyyNTDSK
0	8		Y612-p	LHKKyDyyyNTDSKE
0	3		Y613-p	HKKyDyyyNTDSKES
0	1		T624-p	SKESSWVtPESCLyK
0	4		Y630-p	VtPESCLyKESWLTG
0	1		S671-p	LLRFQATssGPILRE
0	1		S672-p	LRFQATssGPILREE
0	1		S685-p	EEFEARKsFLHEQEE
0	1		Y710-p	GYKQRKEyMHRRQtF
2	0		T716-p	EyMHRRQtFIDNTDS
0	6		T735-p	QSWFRMAtARKsyLS
0	6		S739-p	RMAtARKsyLSRLQy
0	2		Y740-p	MAtARKsyLSRLQyF
0	19		Y746-p	syLSRLQyFRDHNNE
0	1		K756	DHNNEIVKIQsLLRA
0	3		S759-p	NEIVKIQsLLRANKA
0	2		N764	IQsLLRANKARDDyk
0	30		Y770-p	ANKARDDyktLVGSE
0	1		K771-a	NKARDDyktLVGSEN
0	1		K771	NKARDDyKtLVGSEN
0	2		T772-p	KARDDyktLVGSENP
0	1		K786-a	PPLTVIRkFVYLLDQ
0	3		K814-u	LREEVVTkIRANQQL
0	1		K823	RANQQLEKDLNLMDI
0	1		Q869	ILNNTDNQGIKSLSK
0	1		K880	SLSKERRKtLETyQQ
0	15		T881-p	LSKERRKtLETyQQL
0	1		Y885-p	RRKtLETyQQLFyLL
0	1		Y890-p	ETyQQLFyLLQTNPL
0	1		K940	YLLLKLFKTALEEEI
0	1		K950	LEEEIKSKVDQVQDI
0	1		K990	QLLAPVVKEIIDDKS
0	1		K996	VKEIIDDKSLIINTN
0	2		K1024-u	TQTGEASkLPYDVTT
0	1		K1041	ALTYPEVKNKLEASI
0	1		K1043	TYPEVKNKLEASIEN
0	15		Y1106-p	IVGNLLYyRYMNPAI
0	1		Y1167-p	HLSSMNNyLSETyQE
0	1		Y1172-p	NNyLSETyQEFRKYF
0	1		K1177	ETyQEFRKYFKEACN
0	1		T1276-p	TLSQLSKtEISLVLT
0	1		S1284-p	EISLVLTsKYDIEDG
0	1		E1289	LTsKYDIEDGEAIDS
0	1		K1305	SLMIKTKKLIIDVIR
0	1		T1337	QQEVDHATDMVSRAM
0	1		T1349-p	RAMIDSRtPEEMkHs
0	2		K1354-u	SRtPEEMkHsQsMIE
0	3		S1356-p	tPEEMkHsQsMIEDA
0	2		S1358-p	EEMkHsQsMIEDAQL
0	1		S1389	EQTGHVSSENKyQDI
0	1		K1392	GHVSSENKyQDILNE
0	3		Y1393-p	HVSSENKyQDILNEI
0	1		K1402	DILNEIAKDIRNQRI
0	1		K1420	LRKAELAKLQQTLNA
0	1		K1430	QTLNALNKKAAFyEE
0	1		K1431	TLNALNKKAAFyEEQ
0	1		Y1435-p	LNKKAAFyEEQINYY
0	1		Y1445-p	QINYYDTyIKTCLDN
0	1		K1454	KTCLDNLKRKNtRRs
0	3		T1458-p	DNLKRKNtRRsIKLD
0	9		S1461-p	KRKNtRRsIKLDGkG
0	6		K1467-a	RsIKLDGkGEPkGAk
0	7		K1471-a	LDGkGEPkGAkRAKP
0	6		K1474-a	kGEPkGAkRAKPVKY
0	1		K1489	TAAKLHEKGVLLDID
0	1		K1524	GIFDVRSKFLGVEME

	mouse
Y14	PSLQRPRYGsIVDDE
S16-p	LQRPRYGsIVDDERL
S24	IVDDERLSAEEMDER
Y38	RRRQNIAYEYLCHLE
K77	RNGVYLAKLAkFFAP
K80-u	VYLAKLAkFFAPkMV
K85-u	LAkFFAPkMVSEKKI
K91	PkMVSEKKIyDVEQT
Y93-p	MVSEKKIyDVEQTRY
A122	QWLRAMEAIGLPkIF
K127-u	MEAIGLPkIFYPETT
Y137	YPETTDVYDRKNIPR
K171	QIQDLLGKVDFTEEE
Y189	MRKELEKYGIQMPAF
A195	KYGIQMPAFSKIGGI
S197	GIQMPAFSKIGGILA
K231-u	AIEKGVAkQTIITLR
Y255	DDSLSQEYQkELWEA
K257-u	SLSQEYQkELWEAKK
Y285-p	SEEERDAyEELLTQA
Y494	DPDCAQHYQDVLFYT
F499	QHYQDVLFYTKSQKL
K552-u	VNECLDRkQsDHILT
S554-p	ECLDRkQsDHILTAL
K578-u	ILPECANkYYDTLVk
Y579	LPECANkYYDTLVkA
Y580	PECANkYYDTLVkAK
K585-u	kYYDTLVkAKESKTD
K590	LVkAKESKTDNESSE
T591	VkAKESKTDNESSEG
S595	ESKTDNESSEGSWVT
S596	SKTDNESSEGSWVTL
Y609	TLNVQEKYNYYYNTD
Y611	NVQEKYNYYYNTDSK
Y612	VQEKYNYYYNTDSKE
Y613	QEKYNYYYNTDSKEG
P624	SKEGSWVPPELCLSK
S630	VPPELCLSKESWLTG
T671	LVRFEATTLGPALRE
L672	VRFEATTLGPALREE
A685	EEFEARKAFLYEQTE
Y710	GFKQRQEYLHRQQVF
V716	EYLHRQQVFAGNVDS
T735	QSWFRMVTARKSYLS
S739	RMVTARKSYLSRLRY
Y740	MVTARKSYLSRLRYF
Y746	SYLSRLRYFEDHKNE
K756-u	DHKNEIVkIQsLLRA
S759-p	NEIVkIQsLLRAsKA
S764-p	IQsLLRAsKARDDYk
Y770	AsKARDDYkALVGSE
K771	sKARDDYKALVGSEN
K771-u	sKARDDYkALVGSEN
A772	KARDDYkALVGSENP
K786	PPLTVIRKFVYLLDQ
K814-u	LREEVVTkIRANQQL
K823-u	RANQQLEkDLNLMDI
K869-u	ILNNTDNkGIKSLSK
K880-u	SLSKERRktLETYQQ
T881-p	LSKERRktLETYQQL
Y885	RRktLETYQQLFYLL
Y890	ETYQQLFYLLQTKPS
K940-u	YLLLKLFkTALEEEI
K950-u	LEEEIKSkVDQVQDI
K990-u	QLLAPVVkEIIEDkA
K996-u	VkEIIEDkALVINTN
K1024-u	TQTGEASkLPYDVTT
K1041-u	ALTYPEVkNkLEASI
K1043-u	TYPEVkNkLEASIEN
Y1106-p	IVGNLLYyRYMNPAI
Y1167	HLSSMNNYLSETYQE
Y1172	NNYLSETYQEFRkYF
K1177-u	ETYQEFRkYFQEACD
T1276	TLNQLSKTEISLSLT
S1284	EISLSLTSKYDVkDG
K1289-u	LTSKYDVkDGEAVDG
K1305-u	SLMIKTKkLIIDVTR
K1337-u	QQELEHAkDMESRAV
T1349	RAVVDSRTPEEGkQS
K1354-u	SRTPEEGkQSQAVIE
S1356	TPEEGkQSQAVIEDA
A1358	EEGkQSQAVIEDARL
S1389-p	EQTGHVSsKNkYQDI
K1392-u	GHVSsKNkYQDILNE
Y1393	HVSsKNkYQDILNEI
K1402-u	DILNEIAkDIRNQRI
K1420-u	LRKAELSkLQQTLNA
K1430-u	QTLNALNkkAAFYED
K1431-u	TLNALNkkAAFYEDQ
Y1435	LNkkAAFYEDQINYY
Y1445	QINYYDTYIKTCVDN
K1454-u	KTCVDNLkRKNsRRs
S1458-p	DNLkRKNsRRsIKLD
S1461-p	kRKNsRRsIKLDGKA
K1467	RsIKLDGKAEPKGTK
K1471	LDGKAEPKGTKRVKP
K1474	KAEPKGTKRVKPVRY
K1489-u	TAAKLHDkGVLLGID
K1524-u	GIFDVRSkFLGVEME

	rat
Y14	PSLQRPRYGSIVDDE
S16	LQRPRYGSIVDDERL
S24	IVDDERLSAEEMDER
Y38	RRRQNIAYEYLCHLE
K77	RNGVYLAKLAKFFAP
K80	VYLAKLAKFFAPKVV
K85	LAKFFAPKVVSEKKI
K91	PKVVSEKKIYDVEQS
Y93	VVSEKKIYDVEQSRY
A122	QWLRAMEAIGLPKIF
K127	MEAIGLPKIFYPETT
Y137	YPETTDVYDRKNIPR
K171	QIQDLLGKVDFTEEE
Y189	MRKELEKYGIQMPAF
A195	KYGIQMPAFSKIGGI
S197	GIQMPAFSKIGGILA
K231	AIEKGVAKQTIITLR
Y255	DDSLSQEYQKELWEA
K257	SLSQEYQKELWEAKK
Y285	SEEERDAYEELLTQA
Y494	DPDCAHHYQDVLFHT
F499	HHYQDVLFHTKSQKL
K552	VNECLDRKQSDDILT
S554	ECLDRKQSDDILTVL
K578	ILPECANKYFDTLMK
Y579	LPECANKYFDTLMKA
F580	PECANKYFDTLMKAK
K585	KYFDTLMKAKESKTD
K590	LMKAKESKTDGEPTE
T591	MKAKESKTDGEPTEG
P595	ESKTDGEPTEGPWVK
T596	SKTDGEPTEGPWVKL
Y609	KLDVQQKYNYYYNTD
Y611	DVQQKYNYYYNTDSK
Y612	VQQKYNYYYNTDSKE
Y613	QQKYNYYYNTDSKEG
P624	SKEGSWIPPESCLCK
C630	IPPESCLCKESWLTG
N671	LLRFEATNSGPILRE
S672	LRFEATNSGPILREE
A685	EEFEARKAFLYKQVG
Y710	GYKQRQEYLHRQQVF
V716	EYLHRQQVFARNVDS
T735	QSWFRMVTARKSYLS
S739	RMVTARKSYLSRLQY
Y740	MVTARKSYLSRLQYF
Y746	SYLSRLQYFEDHENE
K756	DHENEIVKIQSLLRA
S759	NEIVKIQSLLRASKA
S764	IQSLLRASKARDDYK
Y770	ASKARDDYKALVGSE
K771	SKARDDYKALVGSEN
K771	SKARDDYKALVGSEN
A772	KARDDYKALVGSENP
K786	PPLTVIRKFVYLLDQ
K814	LREEVVTKIRANQQL
K823	RANQQLEKDLNLMDI
Q869	ILTNTDNQGIKSLSK
K880	SLSKERRKTLETYQQ
T881	LSKERRKTLETYQQL
Y885	RRKTLETYQQLFYLL
Y890	ETYQQLFYLLQTKPS
K940	YLLLKLFKTALEEEI
K950	LEEEIKSKVDQVQDI
K990	QLLAPVVKEIIEDKA
K996	VKEIIEDKALIINTN
K1024	TQTGEASKLPYDVTT
K1041	ALTYPEVKNKLEASI
K1043	TYPEVKNKLEASIEN
Y1106	IVGNLLYYRYMNPAI
Y1167	HLSSMNNYLSETYQE
Y1172	NNYLSETYQEFRKYF
K1177	ETYQEFRKYFQEACD
T1276	TLNQLSKTEISLSLT
S1284	EISLSLTSKYDVKDG
K1289	LTSKYDVKDGEAIDG
K1305	SLMIKTKKLIIDVVR
K1337	QQELEHTKDMESRAV
A1349	RAVADSRALEEGKQS
K1354	SRALEEGKQSQAVIE
S1356	ALEEGKQSQAVIEDA
A1358	EEGKQSQAVIEDASL
S1389	EQTGHVSSKNKYQDI
K1392	GHVSSKNKYQDILNE
Y1393	HVSSKNKYQDILNEI
K1402	DILNEIAKDIRNQRI
K1420	LRKAELSKLQQTLNA
K1430	QTLNALNKKAAFYED
K1431	TLNALNKKAAFYEDQ
Y1435	LNKKAAFYEDQINYY
Y1445	QINYYDTYIKTCVDN
K1454	KTCVDNLKRKNSRRS
S1458	DNLKRKNSRRSIKLD
S1461	KRKNSRRSIKLDGKA
K1467	RSIKLDGKAEPKGTK
K1471	LDGKAEPKGTKRVKP
K1474	KAEPKGTKRVKPVRY
K1489	TAAKLHDKGVLLGID
K1524	GIFDVRSKFLGVEME

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