endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 220.127.116.11
Cellular Component: Golgi membrane; cytoskeleton; apical part of cell; cytoplasm; plasma membrane; nucleolus; caveola; nucleus; cytosol
Molecular Function: actin monomer binding; calmodulin binding; protein binding; FAD binding; nitric-oxide synthase activity; FMN binding; iron ion binding; heme binding; NADP binding; cadmium ion binding
Biological Process: response to peptide hormone stimulus; regulation of systemic arterial blood pressure by endothelin; negative regulation of smooth muscle cell proliferation; positive regulation of apoptosis; negative regulation of potassium ion transport; negative regulation of muscle hyperplasia; positive regulation of vasodilation; nitric oxide metabolic process; response to estradiol stimulus; negative regulation of cell proliferation; regulation of blood pressure; negative regulation of hydrolase activity; lipopolysaccharide-mediated signaling pathway; response to lipoprotein stimulus; angiogenesis; nitric oxide biosynthetic process; regulation of blood vessel size; aging; response to drug; mitochondrion organization and biogenesis; interaction with host; negative regulation of calcium ion transport; in utero embryonic development; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; response to amino acid stimulus; ovulation from ovarian follicle; positive regulation of angiogenesis; response to hyperoxia; response to ethanol; response to mechanical stimulus; response to heat; response to cytokine stimulus; response to lead ion; response to hypoxia; arginine catabolic process; endothelial cell migration; blood vessel remodeling; regulation of nitric-oxide synthase activity; blood coagulation; smooth muscle hyperplasia; negative regulation of apoptosis; lung development
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.