Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Other Amino Acids Metabolism - cyanoamino acid; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Methyltransferase; EC 18.104.22.168; Cofactor and Vitamin Metabolism - one carbon pool by folate; Energy Metabolism - methane
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.