Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; Other Amino Acids Metabolism - cyanoamino acid; Cofactor and Vitamin Metabolism - one carbon pool by folate; Mitochondrial; Energy Metabolism - methane; Methyltransferase; Amino Acid Metabolism - glycine, serine and threonine
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.