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ELK1 (human)

Overview ELK1 a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: DNA binding protein; Transcription factor Cellular Component: nucleus Molecular Function: protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: nerve growth factor receptor signaling pathway; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; positive regulation of transcription, DNA-dependent; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 4 signaling pathway Reference #:  P19419 (UniProtKB) Alt. Names/Synonyms: Elk-1; ELK1; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1 Gene Symbols: ELK1 Molecular weight: 44,888 Da Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  MAPK/Erk in Growth and Differentiation  |  SAPK/JNK Signaling Cascades  |  Signaling Pathways Activating p38 MAPK Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ELK1 1DUX - C/F=1-94 (human)

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	Sites Implicated In
transcription, altered: S383‑p, S389‑p activation: S383‑p, S389‑p intracellular localization: S383‑p molecular association, regulation: S383‑p protein conformation: S383‑p, S389‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y57-p	KNKTNMNyDKLSRAL
1	1		S160-p	YMRSGLYsTFTIQsL
1	0		T161	MRSGLYsTFTIQsLQ
0	1		S166-p	YsTFTIQsLQPQPPP
3	0		K230-s	PPEAPNLkSEELNVE
3	0		K249-s	RALPPEVkVEGPkEE
1	0		K254-s	EVkVEGPkEELEVAG
0	2		S304-p	AGGHAASsPEISQPQ
1	12		S324-p	RDLELPLsPsLLGGP
0	1		S326-p	LELPLsPsLLGGPGP
1	0		T336	GGPGPERTPGSGSGS
1	0		T353-p	QAPGPALtPSLLPTH
1	0		T363-p	LLPTHTLtPVLLtPS
1	0		T368-p	TLtPVLLtPSSLPPS
35	1		S383-p	IHFWSTLsPIAPRsP
7	0		S389-p	LsPIAPRsPAKLSFQ
0	1		S416-p	SISVDGLstPVVLsP
5	1		T417-p	ISVDGLstPVVLsPG
1	6		S422-p	LstPVVLsPGPQKP_

	mouse
Y57	KNKTNMNYDKLSRAL
S159	YMRSGLYSTFTIQSL
T160	MRSGLYSTFTIQSLQ
S165	YSTFTIQSLQPQPQP
K231	PPEAPNQKSEELSLD
K250	HPQPPEVKVEGPKEE
K255	EVKVEGPKEELEAAR
T305	VCGLSTSTTEITQPQ
S325-p	RDLELPLsPSLLGGQ
S327	LELPLsPSLLGGQGP
T337-p	GGQGPERtPGSGTSS
T354	QAPGPALTPSLLPTH
T364	LLPTHTLTPVLLTPS
T369	TLTPVLLTPSSLPPS
S384-p	IHFWSTLsPIAPRsP
S390-p	LsPIAPRsPAKLSFQ
S417	SISVDGLSTPVVLsP
T418	ISVDGLSTPVVLsPG
S423-p	LSTPVVLsPGPQKP_

	rat
Y57	KNKTNMNYDKLSRAL
S159-p	YMRSGLYstFTIQSL
T160-p	MRSGLYstFTIQSLQ
S165	YstFTIQSLQPQPPL
K229	PPEAPNQKSEELSLN
K248	RPQPPEVKVEGPKEE
K253	EVKVEGPKEELEVTE
T303	VCGLSTSTTEITQPQ
S323	RDLELPLSPSLLGGQ
S325	LELPLSPSLLGGQGP
T335	GGQGPERTPGSGTSS
T352	QAQGPALTPSLLPTH
T362	LLPTHTLTPVLLTPS
T367	TLTPVLLTPSSLPPS
S382-p	IHFWSTLsPIAPRSP
S388	LsPIAPRSPAKLSFQ
S415	SISVDGLSTPVVLSP
T416	ISVDGLSTPVVLSPG
S421	LSTPVVLSPGPQKP_

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