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Protein Page:
ELK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ELK1 a transcription factor of the Ets family and the ternary complex factor (TCF) subfamily. Forms a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. Mediates gene activity in response to serum and growth factors. Phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus; phosphorylation at these sites is critical for transcriptional activation by Elk-1. Two alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleolus; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; cell differentiation; toll-like receptor 4 signaling pathway
Reference #:  P19419 (UniProtKB)
Alt. Names/Synonyms: Elk-1; ELK1; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1
Gene Symbols: ELK1
Molecular weight: 44,888 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ELK1

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S383‑p, S389‑p
transcription, induced: S324‑p, S383‑p, S389‑p
activity, induced: S324‑p, S383‑p, S389‑p
intracellular localization: S383‑p
molecular association, regulation: S383‑p
protein conformation: S324‑p, S383‑p, S389‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y57-p KNKTNMNyDKLSRAL
1 1 S160-p YMRSGLYsTFTIQsL
1 0 T161 MRSGLYsTFTIQsLQ
0 1 S166-p YsTFTIQsLQPQPPP
3 0 K230-sm PPEAPNLkSEELNVE
3 0 K249-sm RALPPEVkVEGPkEE
1 0 K254-sm EVkVEGPkEELEVAG
0 1 S303-p QAGGHAAssPEISQP
0 2 S304-p AGGHAAssPEISQPQ
2 14 S324-p RDLELPLsPsLLGGP
0 1 S326-p LELPLsPsLLGGPGP
1 0 T336 GGPGPERTPGSGSGS
1 0 T353-p QAPGPALtPSLLPTH
1 0 T363-p LLPTHTLtPVLLtPS
1 0 T368-p TLtPVLLtPSSLPPS
35 1 S383-p IHFWSTLsPIAPRsP
7 0 S389-p LsPIAPRsPAKLSFQ
0 1 S416-p SISVDGLstPVVLsP
5 1 T417-p ISVDGLstPVVLsPG
1 6 S422-p LstPVVLsPGPQKP_
9181 : Phospho-Elk-1 (Ser383) Antibody
9186 : Phospho-Elk-1 (Ser383) (2B1) Mouse mAb
  mouse

 
Y57 KNKTNMNYDKLSRAL
S159 YMRSGLYSTFTIQSL
T160 MRSGLYSTFTIQSLQ
S165 YSTFTIQSLQPQPQP
K231 PPEAPNQKSEELSLD
K250 HPQPPEVKVEGPKEE
K255 EVKVEGPKEELEAAR
S304 QVCGLSTSTTEITQP
T305 VCGLSTSTTEITQPQ
S325-p RDLELPLsPSLLGGQ
S327 LELPLsPSLLGGQGP
T337-p GGQGPERtPGSGTSS
T354 QAPGPALTPSLLPTH
T364 LLPTHTLTPVLLTPS
T369 TLTPVLLTPSSLPPS
S384-p IHFWSTLsPIAPRsP
S390-p LsPIAPRsPAKLSFQ
S417 SISVDGLSTPVVLsP
T418 ISVDGLSTPVVLsPG
S423-p LSTPVVLsPGPQKP_
9181 : Phospho-Elk-1 (Ser383) Antibody
9186 : Phospho-Elk-1 (Ser383) (2B1) Mouse mAb
  rat

 
Y57 KNKTNMNYDKLSRAL
S159-p YMRSGLYstFTIQSL
T160-p MRSGLYstFTIQSLQ
S165 YstFTIQSLQPQPPL
K229 PPEAPNQKSEELSLN
K248 RPQPPEVKVEGPKEE
K253 EVKVEGPKEELEVTE
S302 QVCGLSTSTTEITQP
T303 VCGLSTSTTEITQPQ
S323 RDLELPLSPSLLGGQ
S325 LELPLSPSLLGGQGP
T335 GGQGPERTPGSGTSS
T352 QAQGPALTPSLLPTH
T362 LLPTHTLTPVLLTPS
T367 TLTPVLLTPSSLPPS
S382-p IHFWSTLsPIAPRSP
S388 LsPIAPRSPAKLSFQ
S415 SISVDGLSTPVVLSP
T416 ISVDGLSTPVVLSPG
S421 LSTPVVLSPGPQKP_
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