Home

SKIV2L2 (human)

Overview SKIV2L2 May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'processing of the 7S pre-RNA to the mature 5.8S rRNA. Belongs to the helicase family. SKI2 subfamily. Note: This description may include information from UniProtKB. Protein type: Helicase; DNA binding protein; EC 3.6.1.-; EC 3.6.4.13 Cellular Component: nucleolus; exosome (RNase complex); nucleus Molecular Function: protein binding; nucleic acid binding; ATP-dependent helicase activity; ATP binding Biological Process: nuclear mRNA splicing, via spliceosome; maturation of 5.8S rRNA Reference #:  P42285 (UniProtKB) Alt. Names/Synonyms: ATP-dependent helicase SKIV2L2; Dob1; fSAP118; functional spliceosome-associated protein 118; KIAA0052; MGC142069; Mtr4; SK2L2; SKIV2L2; Superkiller viralicidic activity 2-like 2; superkiller viralicidic activity 2-like 2 (S. cerevisiae) Gene Symbols: SKIV2L2 Molecular weight: 117,805 Da Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states

Select Structure to View Below SKIV2L2

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  ENZYME  |  InnateDB  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S40-p	KWKGPPGsADKAGKR
0	2		K51-a	AGKRFDGkLQSESTN
0	1		K51	AGKRFDGKLQSESTN
0	4		K78-a	TDEPIFGkKPRIEES
0	1		Y136-p	VGKAAKEyPFILDAF
0	2		T188-p	EKQRVIFtsPIkALS
0	3		S189-p	KQRVIFtsPIkALSN
0	1		K192-u	VIFtsPIkALSNQkY
0	1		K198-a	IkALSNQkYREMYEE
0	1		K358-u	RDAGDLAkGDQKGRK
0	1		K379-a	SNVFKIVkMIMERNF
0	2		K396-a	VIIFSFSkKDCEAyA
0	1		Y402-p	SkKDCEAyALQMtKL
0	1		T407-p	EAyALQMtKLDFNtD
0	1		T413-p	MtKLDFNtDEEkKMV
0	1		K417-u	DFNtDEEkKMVEEVF
0	1		K437	CLSDEDKKLPQVEHV
0	6		T466-p	LLPILKEtIEILFsE
0	6		S472-p	EtIEILFsEGLIKAL
0	1		T499-p	PARTVLFtNARKFDG
0	1		Y517-p	RWISSGEyIQMSGRA
0	1		Y583-p	VEEINPEyMLEkSFy
0	1		K587-u	NPEyMLEkSFyQFQH
0	2		Y590-p	yMLEkSFyQFQHYRA
0	1		S608	VVEKVKNSEEQYNkI
0	1		K614-u	NSEEQYNkIVIPNEE
0	2		Y694-p	SGELDPLyVVEVLLR
0	1		K748-a	SVRLYIPkDLRPVDN
0	2		K761-u	DNRQSVLkSIQEVQK
0	2		K792-a	IQDQGLKkVIQkVEA
0	1		K796-a	GLKkVIQkVEAFEHR
0	1		K796	GLKkVIQKVEAFEHR
0	1		K840	KSAKRELKKARTVLQ
0	1		K841	SAKRELKKARTVLQM
0	1		K873-u	SSDVIEMkGRVACEI
0	2		K1022-u	GNTELENkFAEGITK

	mouse
S38	KWKGPPGSADKAGKR
K49	AGKRLDTKLQSESAS
K49-u	AGKRLDTkLQSESAS
K76	TDEPIFGKKPRIEDS
Y134	VGKAAKEYPFILDAF
T186-p	EKQRVIFtsPIKALS
S187-p	KQRVIFtsPIKALSN
K190	VIFtsPIKALSNQKY
K196	IKALSNQKYREMYEE
K356	RDAGDLAKGDQKGRK
K377	SNVFKIVKMIMERNF
K394	VIIFSFSKKDCEAYA
Y400	SKKDCEAYALQMTKL
T405	EAYALQMTKLDFNTD
T411	MTKLDFNTDEEKKMV
K415	DFNTDEEKKMVEEVF
K435-u	CLSDEDKkLPQVEHV
T464	LLPILKETIEILFSE
S470	ETIEILFSEGLIKAL
T497	PARTVLFTNARKYDG
Y515	RWISSGEYIQMSGRA
Y581	VEEINPEYMLEKSFY
K585	NPEYMLEKSFYQFQH
Y588	YMLEKSFYQFQHYRA
S606-p	VVEKVKNsEEQYNKI
K612	NsEEQYNKIVIPNEE
Y692-p	SGELDPLyVVEVLLR
K746	TVRLYIPKDLRPVDN
K759-u	DNRQSVLkSIQEVQR
K790	IQDQGLKKVIQkVEA
K794	GLKKVIQKVEAFEHR
K794-u	GLKKVIQkVEAFEHR
K838-a	KSAKRELkkARTVLQ
K839-a	SAKRELkkARTVLQM
K871	SSDVIEMKGRVACEI
K1020	GNTELENKFAEGITK

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.