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eIF4E (human)

Overview eIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB. Protein type: Translation; Translation initiation Cellular Component: mRNA cap complex; stress granule; eukaryotic translation initiation factor 4F complex; cytosol Molecular Function: protein binding; translation initiation factor activity; RNA cap binding Biological Process: translation; cytokine and chemokine mediated signaling pathway; positive regulation of mitotic cell cycle; mRNA metabolic process; regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; RNA metabolic process; virus-host interaction; insulin receptor signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; G1/S transition of mitotic cell cycle Reference #:  P06730 (UniProtKB) Alt. Names/Synonyms: CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E; EIF4E1; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; IF4E; MGC111573; mRNA cap-binding protein Gene Symbols: EIF4E Molecular weight: 25,097 Da Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below eIF4E 1IPB - A=1-217 (human) 1IPC - A=1-217 (human) 1WKW - A=27-217 (human) 2GPQ - A=1-217 (human) 2V8W - A/E=1-217 (human) 2V8X - A/E=1-217 (human) 2V8Y - A/E=1-217 (human) 2W97 - A/B=1-217 (human) 3AM7 - A=27-217 (human) 3SMU - A/B=1-217 (human) 3TF2 - A/D/C/B=1-217 (human) 3U7X - A/B=1-217 (human) 4AZA - A/C=1-217 (human) 4DT6 - A=1-217 (human) 4DUM - A=1-217 (human) 1EJ1 - A/B=28-217 (mouse) 1EJ4 - A=28-217 (mouse) 1EJH - A/D/C/B=28-217 (mouse) 1L8B - A/B=28-217 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3SMU 3TF2 3U7X 4AZA 4DT6 4DUM  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: S209, T210

	Modification Sites and Domains
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	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T3	_____MAtVEPETtP
0	2		T9	AtVEPETtPTPNPPt
0	1		T16	tPTPNPPttEEEKTE
0	1		T17	PTPNPPttEEEKTES
0	1		S24	tEEEKTESNQEVANP
2	0		S53	WFFKNDKsKTWQANL
0	2		Y183	VTHIGRVyKERLGLP
0	1		T203	GYQSHADtATKSGst
38	2		S209	DtATKSGstTKNRFV
3	1		T210	tATKSGstTKNRFVV

	mouse
T3	_____MATVEPETTP
T9	ATVEPETTPTTNPPP
P16	TPTTNPPPAEEEKTE
A17	PTTNPPPAEEEKTEs
S24	AEEEKTEsNQEVANP
S53	WFFKNDKSKTWQANL
Y183	VTHIGRVYKERLGLP
T203	GYQSHADTATKSGst
S209	DTATKSGstTKNRFV
T210	TATKSGstTKNRFVV

	rat
T3	_____MATVEPETTP
T9	ATVEPETTPTTNPPP
P16	TPTTNPPPAEEEKTE
A17	PTTNPPPAEEEKTES
S24	AEEEKTESNQEVANP
S53	WFFKNDKSKTWQANL
Y183	VTHIGRVyKERLGLP
T203	GYQSHADTATKSGsT
S209	DTATKSGsTTKNRFV
T210	TATKSGsTTKNRFVV

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