Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
eIF4E (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
eIF4E a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component: mRNA cap complex; stress granule; cytoplasm; eukaryotic translation initiation factor 4F complex; cytosol
Molecular Function: protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity; RNA cap binding
Biological Process: translation; viral reproduction; cytokine and chemokine mediated signaling pathway; positive regulation of mitotic cell cycle; mRNA metabolic process; regulation of translation; poly(A) tail shortening; mRNA export from nucleus; cellular protein metabolic process; RNA metabolic process; insulin receptor signaling pathway; translational initiation; gene expression; mRNA catabolic process, deadenylation-dependent decay; lung development; G1/S transition of mitotic cell cycle
Reference #:  P06730 (UniProtKB)
Alt. Names/Synonyms: CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E; EIF4E1; EIF4EL1; EIF4F; Eukaryotic translation initiation factor 4E; eukaryotic translation initiation factor 4E-like 1; IF4E; MGC111573; mRNA cap-binding protein
Gene Symbols: EIF4E
Molecular weight: 25,097 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  Insulin Receptor Signaling  |  Translation: eIF4E and p70S6K  |  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

eIF4E

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell growth, altered: S209‑p, T210‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T3-p _____MAtVEPETtP
0 1 - gap
0 1 - gap
0 2 T9-p AtVEPETtPTPNPPt
0 1 T16-p tPTPNPPttEEEKtE
0 1 T17-p PTPNPPttEEEKtEs
0 1 T22-p PttEEEKtEsNQEVA
0 3 S24-p tEEEKtEsNQEVANP
0 1 K36-ub ANPEHYIkHPLQNRW
2 0 S53-p WFFKNDKsKTWQANL
0 1 K119-ac RWLITLNkQQRRSDL
0 1 K119 RWLITLNKQQRRSDL
1 0 K159-ub AVVNVRAkGDKIAIW
0 2 Y183-p VTHIGRVyKERLGLP
0 1 T203-p GYQSHADtATKSGst
41 2 S209-p DtATKSGstTKNRFV
3 1 T210-p tATKSGstTKNRFVV
9741 : Phospho-eIF4E (Ser209) Antibody
  eIF4E iso4  
- gap
K11-m1 KQNKKERkkMRAEDG
K12-m1 QNKKERkkMRAEDGE
T37 LRESQETTPTPNPPT
T44 TPTPNPPTTEEEKTE
T45 PTPNPPTTEEEKTES
T50 PTTEEEKTESNQEVA
S52 TEEEKTESNQEVANP
K64 ANPEHYIKHPLQNRW
S81 WFFKNDKSKTWQANL
K147 RWLITLNKQQRRSDL
K147 RWLITLNKQQRRSDL
K187 AVVNVRAKGDKIAIW
Y211 VTHIGRVYKERLGLP
T231 GYQSHADTATKSGST
S237 DTATKSGSTTKNRFV
T238 TATKSGSTTKNRFVV
  mouse

 
T3 _____MATVEPETTP
- gap
- gap
T9 ATVEPETTPTTNPPP
P16 TPTTNPPPAEEEKTE
A17 PTTNPPPAEEEKTEs
T22 PPAEEEKTEsNQEVA
S24-p AEEEKTEsNQEVANP
K36 ANPEHYIKHPLQNRW
S53 WFFKNDKSKTWQANL
K119 RWLITLNKQQRRSDL
K119-ub RWLITLNkQQRRSDL
K159 AVVNVRAKGDKIAIW
Y183 VTHIGRVYKERLGLP
T203 GYQSHADTATKSGst
S209-p DTATKSGstTKNRFV
T210-p TATKSGstTKNRFVV
9741 : Phospho-eIF4E (Ser209) Antibody
  rat

 
T3 _____MATVEPETTP
- gap
- gap
T9 ATVEPETTPTTNPPP
P16 TPTTNPPPAEEEKTE
A17 PTTNPPPAEEEKTES
T22 PPAEEEKTESNQEVA
S24 AEEEKTESNQEVANP
K36 ANPEHYIKHPLQNRW
S53 WFFKNDKSKTWQANL
K119 RWLITLNKQQRRSDL
K119 RWLITLNKQQRRSDL
K159 AVVNVRAKGDKIAIW
Y183-p VTHIGRVyKERLGLP
T203 GYQSHADTATKSGsT
S209-p DTATKSGsTTKNRFV
T210 TATKSGsTTKNRFVV
9741 : Phospho-eIF4E (Ser209) Antibody
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.