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Protein Page:
CUL1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CUL1 a core scaffolding component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. The cullin subunit serves as a rigid scaffold of SCF complexes. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex depends on the neddylation of the cullin subunit. Interacts with multiple F-box proteins in SCF complexes, directing the ubiquitination of many substrates. These F-box proteins and associated substrates include: BTRC and FBXW11 bind CTNNB1 and participate in Wnt signaling; FBXW11 bind phosphorylated NFKBIA; BTRC binds NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2; SKP2 binds phosphorylated p27kip and is involved in regulation of G1/S transition; SKP2 binds ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1; FBXW7 binds cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1; FBXW2 binds GCM1; FBXO32 binds MYOD1; FBXO7 binds BIRC2 and DLGAP5; FBXO33 binds YBX1; and Cyclin F binds CP110. Interacts with CHEK2, mediating its ubiquitination and regulating its function. Belongs to the cullin family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system; Cell cycle regulation
Cellular Component: nucleoplasm; cullin-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein monoubiquitination; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; viral reproduction; protein ubiquitination; cell proliferation; negative regulation of cell proliferation; organ morphogenesis; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; cell cycle arrest; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle
Reference #:  Q13616 (UniProtKB)
Alt. Names/Synonyms: CUL-1; CUL1; cullin 1; Cullin-1; MGC149834; MGC149835
Gene Symbols: CUL1
Molecular weight: 89,679 Da
Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CUL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K13-ac SQNPHGLkQIGLDQI
0 8 R63-m1 VHQSNQArGAGVPPs
0 1 S70-p rGAGVPPsKSKKGQt
0 1 T77-p sKSKKGQtPGGAQFV
0 5 K131-ub EDYRFSSkVLNGICA
0 1 T409-p FINNNAVtkMAQSSS
0 49 K410-ub INNNAVtkMAQSSSK
0 1 Y425-p SPELLARyCDSLLkK
0 1 K431-ac RyCDSLLkKSSKNPE
0 1 K464-ub EDKDVFQkFYAkMLA
0 1 K468-ub VFQkFYAkMLAKRLV
0 2 K587-ub TWLYQLSkGELVTNC
0 1 K689-ac VNINVPMkTEQKQEQ
0 1 K689-ub VNINVPMkTEQKQEQ
1 1 K708-ub KNIEEDRkLLIQAAI
1 11 K720-ub AAIVRIMkMRKVLKH
0 1 K720-ne AAIVRIMkMRKVLKH
0 1 K769-ne LERVDGEkDTYSYLA
0 31 K769-ub LERVDGEkDTYSYLA
  mouse

 
K13 SQNPHGLKQIGLDQI
R63-m1 VHQSNQArGAGVPPS
S70 rGAGVPPSKSKKGQT
T77 SKSKKGQTPGGAQFV
K131 EDYRFSSKVLNGICA
T409 FINNNAVTkMAQSSS
K410-ub INNNAVTkMAQSSSK
Y425 SPELLARYCDSLLKK
K431 RYCDSLLKKSSKNPE
K464 EDKDVFQKFYAKMLA
K468 VFQKFYAKMLAKRLV
K587 TWLYQLSKGELVTNC
K689 VNINVPMKTEQKQEQ
K689 VNINVPMKTEQKQEQ
K708 KNIEEDRKLLIQAAI
K720-ub AAIVRIMkMRKVLKH
K720 AAIVRIMKMRKVLKH
K769 LERVDGEKDTYSYLA
K769-ub LERVDGEkDTYSYLA
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